SIMULATION OF ELECTRIC STIMULATION FOR BONE GROWTH

骨骼生长的电刺激模拟

• 批准号: 8363711
• 负责人: Rob S. MacLeod
• 金额: $ 8.88万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363711
• 关键词: Address; Amputation; Amputees; Biological; Biomedical Computing; Bone Growth; Caring; Clinical; Collaborations; Complex; Computer Simulation; Dental; Electric Stimulation; Elements; Evaluation; Finite Element Analysis; Fracture Healing; Funding; Future; Goals; Grant; Image; Imagery; Implant; In Vitro; Injury; Limb structure; Mechanics; Medical; Methods; Modality; Modeling; National Center for Research Resources; Operative Surgical Procedures; Osseointegration; Patients; Phase; Principal Investigator; Prosthesis; Rehabilitation therapy; Research; Research Infrastructure; Residual state; Resources; Safety; Scanning; Services; Source; Survival Rate; Technology; Testing; Tissues; Uncertainty; United States National Institutes of Health; Veterans; War; X-Ray Computed Tomography; base; bone; combat; computer infrastructure; cost; density; design; electric field; external ear auricle; follow-up; improved; in vivo; models and simulation; research and development; sample fixation; simulation; skeletal; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Improvements in medical care and evacuation strategies on the field of combat have led to an increased number of veterans surviving disastrous war related injuries. While the improved survival rate is a medical advance, many veterans are returning from combat with amputations that require complex follow-up care, extensive rehabilitation, and expensive prosthetic services. Osseointegration is a surgical procedure that provides direct skeletal attachment between an implant and host tissue with proven success in dental, auricle, and transfemoral implants. However, one challenge with using natural biological fixation is attaining a strong skeletal interlock at the implant interface, a prerequisite for long-term implant function. Therefore, the objective of this study is to build upon the previous, clinical success of electrically induced bone growth used to augment fracture healing, and to expand this technology to improve osseointegration for amputees. Rationale: To validate the general hypothesis that electrical stimulation will increase skeletal attachment, a two-phase project has been designed that utilizes in vitro, in vivo, and in silico modalities to confirm the safety and efficacy of this technology prior to implementation in veteran and warrior amputees. The specific hypotheses for this model are founded on histological assessment, mechanical testing, and finite element analysis. Specifically, finite element-based simulation analysis of veteran and warrior amputee residual limbs imaged with computed tomography scans reveal that safe and effective densities and electric fields will be attainable at the bone-implant interface. Questions: While progress on this DBP has already been substantial, there are many additional hurdles that the Center will need to address in the future. Specific examples of these challenges include image-based modeling, uncertainty visualization, detailed simulation, and estimation accuracy. Design & Methods: The main goal of the Center collaboration with this DBP is to develop a comprehensive and validated computational infrastructure that will support the creation of patient specific models of the residual limbs of amputees to assist in the evaluation and treatment by means of osseointegration. This DBP is another example of the image-based modeling and simulation pipeline that serves as a central framework of the Center's research an development.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 背景资料： 战场上医疗护理和后送战略的改善导致了 越来越多的退伍军人在战争中幸存下来。而 提高存活率是医学上的进步，许多退伍军人从战场上回来， 截肢需要复杂的后续护理，广泛的康复， 昂贵的假肢服务。骨整合是一种外科手术， 植入物和宿主组织之间的骨骼附着在牙科， 耳廓和股骨植入物。然而，使用天然生物制剂的一个挑战是， 固定是在植入物界面获得牢固的骨骼互锁，这是 长期植入功能。因此，本研究的目的是建立在 电诱导骨生长用于增强骨折的既往临床成功 愈合，并扩大这项技术，以改善截肢者的骨整合。 基本原理： 为了验证电刺激会增加骨骼肌 附件，一个两阶段的项目已经设计，利用在体外，在体内， 硅模式，以确认该技术的安全性和有效性之前， 在退伍军人和战士截肢者中实施。该模型的具体假设 基于组织学评估、力学测试和有限元分析。 具体而言，基于有限元的模拟分析退伍军人和战士截肢 计算机断层扫描显示残肢成像安全有效， 在骨-植入物界面处可获得密度和电场。 问题： 虽然在这方面已经取得了实质性进展，但还有许多其他的进展。 这是该中心今后需要解决的问题。这些物质的具体实例 挑战包括基于图像的建模，不确定性可视化，详细的模拟， 和估计精度。 设计与方法： 该中心与DBP合作的主要目标是制定一个全面的， 经验证的计算基础设施，将支持创建患者特定的 截肢者残肢模型，以协助评估和治疗 骨整合的方法。该DBP是基于图像的建模的另一示例， 模拟管道，作为中心研究的中心框架， 发展