STANDARDS FOR DIGITAL REPRESENTATION OF GLYCAN STRUCTURE

聚糖结构的数字表示标准

• 批准号: 8363010
• 负责人: WILLIAM YORK
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363010
• 关键词: Collaborations; Databases; Development; Extensible Markup Language; Funding; German population; Glycoconjugates; Grant; Laboratories; NCI Center for Cancer Research; National Center for Research Resources; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Scientist; Source; Structure; Technology; United States National Institutes of Health; computerized data processing; cost; data exchange; digital; flexibility; tool; transmission process; web services

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development of XML standards for the representation and transmission of glycan structural information. Integrated data processing demands facile information exchange between databases, web services, and other applications. We are developing a standard called GLYDE (GLYcan Data Exchange) using eXtensible Markup Language (XML) that can be understood by commonly used parsing tools, making it accessible to a wide range of potential applications. The utility of GLYDE, our XML format for the unambiguous representation of glycan structures, was recognized by scientists at the German Cancer Research Center and the Consortium for Functional Glycomics. Subsequent discussions led to the initiation of an informal collaboration aimed at developing GLYDE for use as a standard format for the digital transmission of glycan structural information between laboratories. Continuing correspondence has led to a greater appreciation of the issues that must be solved to make a truly useful representational standard. The collaboration emphasizes the continued development of GLYDE-II, which is much more flexible and enables the representation of glycans and glycoconjugates at different levels of granularity.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 开发用于表示和传输聚糖结构信息的 XML 标准。 集成数据处理要求数据库、Web 服务和其他应用程序之间能够轻松交换信息。 我们正在开发一种名为 GLYDE（GLYcan 数据交换）的标准，该标准使用可扩展标记语言 (XML)，可以被常用的解析工具理解，从而使其可供广泛的潜在应用程序使用。 GLYDE 是我们用于明确表示聚糖结构的 XML 格式，其实用性得到了德国癌症研究中心和功能糖组学联盟的科学家的认可。随后的讨论引发了一项非正式合作，旨在开发 GLYDE，用作实验室之间聚糖结构信息数字传输的标准格式。持续的通信使人们更加了解必须解决的问题，以制定真正有用的代表性标准。 此次合作强调了 GLYDE-II 的持续开发，它更加灵活，能够以不同的粒度水平表示聚糖和糖缀合物。