STANDARDS FOR DIGITAL REPRESENTATION OF GLYCAN STRUCTURE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 开发用于聚糖结构信息表示和传输的XML标准。 集成的数据处理要求在数据库、Web服务和其他应用程序之间进行便捷的信息交换。 我们正在开发一种称为GLYDE（GLYcan数据交换）的标准，该标准使用可扩展标记语言（XML），可以通过常用的解析工具进行理解，从而使其可以用于广泛的潜在应用。GLYDE是我们用于明确表示聚糖结构的XML格式，其实用性得到了德国癌症研究中心和功能性糖组学联盟的科学家的认可。随后的讨论促成了一项非正式合作，旨在开发GLYDE，作为实验室之间聚糖结构信息数字传输的标准格式。持续的通信导致了对必须解决的问题的更大理解，以制定真正有用的代表性标准。 此次合作强调了GLYDE-II的持续开发，GLYDE-II更加灵活，能够以不同的粒度水平表示聚糖和糖缀合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development of XML standards for the representation and transmission of glycan structural information. Integrated data processing demands facile information exchange between databases, web services, and other applications. We are developing a standard called GLYDE (GLYcan Data Exchange) using eXtensible Markup Language (XML) that can be understood by commonly used parsing tools, making it accessible to a wide range of potential applications. The utility of GLYDE, our XML format for the unambiguous representation of glycan structures, was recognized by scientists at the German Cancer Research Center and the Consortium for Functional Glycomics. Subsequent discussions led to the initiation of an informal collaboration aimed at developing GLYDE for use as a standard format for the digital transmission of glycan structural information between laboratories. Continuing correspondence has led to a greater appreciation of the issues that must be solved to make a truly useful representational standard. The collaboration emphasizes the continued development of GLYDE-II, which is much more flexible and enables the representation of glycans and glycoconjugates at different levels of granularity.