REACTO, AN ONTOLOGY OF THE REACTIONS INVOLVED IN GLYCAN METABOLISM

REACTO，聚糖代谢反应的本体论

• 批准号: 8363126
• 负责人: WILLIAM YORK
• 金额: $ 3.44万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363126
• 关键词: Anabolism; Biochemical Reaction; Cells; Collection; Complex; Enzymes; Face; Funding; Generations; Grant; Individual; Knowledge; Life; Metabolism; National Center for Research Resources; Ontology; Polysaccharides; Principal Investigator; Process; Reaction; Research; Research Infrastructure; Resources; Source; Structure; Technology; United States National Institutes of Health; chemical reaction; cost; design; enzyme structure; prototype; repository; sugar; sugar nucleotide; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The biosynthesis, remodeling and turnover of glycans in living cells are extremely complex processes. Glycan structure is the result of metabolic processes that include generation of energy-rich precursors such as nucleotide sugars, transfer of individual sugar residues to growing glycan chains, and trimming of the resulting glycan structures. Each of these processes corresponds to a collection of biochemical reactions that are catalyzed by specific enzymes. Thus, an understanding of glycan metabolism requires knowledge of the structures of the relevant glycans, the cellular machinery involved in transforming one structure into another, and the chemical reactions corresponding to these transformations. We designed the ReactO ontology to embody knowledge regarding specific biochemical reactions involved in glycan metabolism, although its general design can be used to describe a broad range of enzyme-catalyzed reactions. That is, ReactO is not designed to embody explicit knowledge of glycan or enzyme structure. Thus, a major challenge that we face in developing ReactO is its full integration with other knowledge repositories that embody this structural knowledge. We are developing ReactO not only as a highly desirable tool for representing and accessing knowledge about glycan metabolism, but as a prototype for integrating several related but highly focused ontologies.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 活细胞中聚糖的生物合成、重塑和周转是极其复杂的过程。 聚糖结构是代谢过程的结果，包括产生富含能量的前体，如核苷酸糖，将单个糖残基转移到生长的聚糖链，以及修剪所得聚糖结构。 这些过程中的每一个都对应于由特定酶催化的生化反应的集合。 因此，了解聚糖代谢需要了解相关聚糖的结构、将一种结构转化为另一种结构所涉及的细胞机制以及与这些转化相对应的化学反应。 我们设计了ReactO本体，以体现有关聚糖代谢中涉及的特定生化反应的知识，尽管其一般设计可用于描述广泛的酶催化反应。 也就是说，ReactO并不旨在体现聚糖或酶结构的明确知识。 因此，我们在开发ReactO时面临的一个主要挑战是它与体现这种结构化知识的其他知识库的完全集成。 我们正在开发的ReactO不仅是一个非常理想的工具，用于表示和访问有关聚糖代谢的知识，但作为一个原型，用于集成几个相关的，但高度集中的本体。