SIMGLYCANTOOL SUITE

SIMGLYCANTOOL 套件

• 批准号: 8363125
• 负责人: WILLIAM YORK
• 金额: $ 3.44万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363125
• 关键词: Computer software; Data; Funding; Grant; Mass Spectrum Analysis; Methods; National Center for Research Resources; Output; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Structure; Technology; United States National Institutes of Health; Work; base; cost; database structure; indexing; programs; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SimGlycan is a commercial software for the interpretation of glycan mass spectrometric data (http://www.premierbiosoft.com/glycan/index.html). The program provides convenient methods for annotation and exploration of mass spectral data. In cooperation with Premier Biosoft developers, we are working on extending this program for high-throughput glycomics analysis. After structural assignment is completed, the SimGlycan product does not support facile exploration of these results. We are developing a suite of tools based on SimGlycan result files that will support the display and exploration of large amount of data generated by high-throughput, mass spectrometry-based glycomics. These tools will: (1) convert the existing output files into a more intuitive and readable format, (2) extend the existing output files with new parameters that are critical to evaluate the annotation, (3) compare the result of several samples, and (4) create a customized SimGlycan structure database based on highly curated structures in GlycO. (See SPID 0142).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 SimGlycan是一种用于解释聚糖质谱数据的商业软件（http：//www.premierbiosoft.com/glycan/index.html）。该程序为质谱数据的注释和探索提供了方便的方法。在与Premier Biosoft开发人员的合作中，我们正在努力将该程序扩展到高通量糖组学分析。结构归属完成后，SimGlycan产品不支持对这些结果的简单探索。 我们正在开发一套基于SimGlycan结果文件的工具，该工具将支持显示和探索由高通量、基于质谱的糖组学生成的大量数据。这些工具将：（1）将现有的输出文件转换成更直观和可读的格式，（2）用对评估注释至关重要的新参数扩展现有的输出文件，（3）比较几个样品的结果，和（4）基于GlycO中的高度策划的结构创建定制的SimGlycan结构数据库。 (See SPID 0142）。