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CRYSTALLOGRAPHIC ANALYSIS OF A BACTERIAL MEMBRANE PROTEASE

CRYSTALLOGRAPHIC ANALYSIS OF A BACTERIAL MEMBRANE PROTEASE
细菌膜蛋白酶的晶体分析
批准号:
8361662
负责人:
YA HA
金额:
$0.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-04-01 至 2012-03-31

项目摘要

项目成果

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中文摘要
翻译
这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的, 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量, 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 大多数导致家族性阿尔茨海默病(AD)的显性突变在两个同源的早老素(PS1,PS2)基因中被发现。目前对早老素蛋白水解酶家族的结构和机制知之甚少。我们计划解决早老素的细菌同系物的晶体结构。这些结构数据可能会揭示一些重要的问题:(I)早老素是如何切割似乎埋在膜中的多肽键的?(Ii)在PS1和PS2的初级序列中都发现了疾病突变。它们都是如何改变切割专一性而有利于毒性更强的A?42的?
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Most dominant mutations that cause Familial Alzheimer's Disease (AD) are found in the two homologous presenilin (PS1, PS2) genes. Little is currently known about the structure and mechanism for the presenilin family of proteases. We plan to solve the crystal structure of a bacterial homolog of presenilin. The structural data is likely to shed light on a number of important questions: (i) How does presenilin cleave peptide bonds that appear to be buried in the membrane? (ii) The disease mutations are found throughout the primary sequence pf PS1 and PS2. How do they all alter the cleavage specificity in favor of the more toxic A¿42?
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The biochemical mechanism and pharmacological inhibition of phosphatidylinositol phosphate kinases
  • 批准号:
    10711064
  • 项目类别:
  • 资助金额:
    $32.2万
  • 财政年份:
    2023
  • 负责人:
    YA HA
  • 依托单位:
Development of novel PIP4K inhibitors to treat p53-null cancer
  • 批准号:
    10260471
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2020
  • 负责人:
    YA HA
  • 依托单位:
Development of novel PIP4K inhibitors to treat p53-null cancer
  • 批准号:
    10387119
  • 项目类别:
  • 资助金额:
    $5.73万
  • 财政年份:
    2020
  • 负责人:
    YA HA
  • 依托单位:
Development of novel PIP4K inhibitors to treat p53-null cancer
  • 批准号:
    10427407
  • 项目类别:
  • 资助金额:
    $33.88万
  • 财政年份:
    2020
  • 负责人:
    YA HA
  • 依托单位:
国内基金
海外基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
Data-driven Recommendation System Construction of an Online Medical Platform Based on the Fusion of Information
Development of a Linear Stochastic Model for Wind Field Reconstruction from Limited Measurement Data
  • 批准号:
    --
  • 项目类别:
    --
  • 资助金额:
    40万元
  • 批准年份:
    2020
  • 负责人:
    Vikrant Gupta
  • 依托单位:
基于Linked Open Data的Web服务语义互操作关键技术
  • 批准号:
    61373035
  • 项目类别:
    面上项目
  • 资助金额:
    77.0万元
  • 批准年份:
    2013
  • 负责人:
    冯志勇
  • 依托单位: