TOWARDS THE COMPLETE CHARACTERIZATION OF NEUREXIN TRANS-SYNAPTIC LIGANDS

神经毒素跨突触配体的完整表征

• 批准号: 8365894
• 负责人: ANIRVAN GHOSH
• 金额: $ 0.74万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365894
• 关键词: Adhesions; Alternative Splicing; Behavior; Biology; Brain; Code; Funding; Fungal Genome; Genes; Grant; Ligands; National Center for Research Resources; Neurons; Organism; Principal Investigator; Protein Isoforms; Proteins; Proteome; Research; Research Infrastructure; Resources; Source; Synapses; United States National Institutes of Health; cost; neural circuit; presynaptic; promoter; protein expression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The identification and characterization of the trans-synaptic adhesion proteome may prove sufficient to break the synapse code. Determination of the trans-synaptic adhesion proteome may prove central to our eventual understanding of neuronal synaptic circuitry and brain wiring and in turn organism behavior. Historically, Neurexins (NRXNs) have been considered the most-likely presynaptic protein responsible for post-synaptic differentiation. NRXN protein expression is highly regulated (3 genes, alternative promoters, and massive alternative splicing) and it has been proposed that NRXNs may be present in thousands of isoforms within the mammalian brain.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 跨突触粘附蛋白质组的鉴定和表征可能足以打破突触密码。跨突触粘附蛋白质组的确定可能会证明我们最终了解神经元突触电路和大脑布线，进而生物体行为的中心。历史上，神经毒素（NRXN）被认为是最有可能负责突触后分化的突触前蛋白。NRXN蛋白的表达受到高度调控（3个基因，选择性启动子和大量选择性剪接），并且已经提出NRXN可能以数千种亚型存在于哺乳动物脑内。