IMAGE FORMATION AND RECONSTRUCTION APPROACHES USING PULSED ESR MICROSCOPY

使用脉冲 ESR 显微镜的图像形成和重建方法

基本信息

  • 批准号:
    8364097
  • 负责人:
  • 金额:
    $ 0.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-01 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Paramagnetic agents are used both as tracers in ESR based imaging and as contrast agents in NMR based imaging to obtain information where they localize in the object being imaged. Imaging using paramagnetic probes applied as tracers in an object of interest in imaging has inherent advantages over NMR. The unique features in ESR based imaging either at a microscopic level or in an in vivo imaging experiment makes it possible to extract important functional information such as local pO2, pH, viscosity etc entities which are significantly more difficult and even challenging in an MRI experiment either at a microscopic or macroscopic level. With the recently available paramagnetic species such as the trityl radicals and solid probes such as LiPc whose spectral properties are optimal for ESR based imaging, it has now become possible at a microscopic level and at an animal level to interrogate at a cellular level: a) subcellular changes in gross redox status changes using redox responsive paramagnetic species; b) sub cellular profiles of oxygen distribution using cell permeable trityl radicals and intra- and extra cellular oxygen gradients using appropriately isotopically labeled spin probes. ACERT will work with the NCI group to examine biological samples from the in vivo experiments where mice receive exposure to radiation in specific organs to such doses that pathologies related to radiation-induced normal tissue fibrosis manifests 4-6 weeks post-radiation.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MURALI CHERUKURI其他文献

MURALI CHERUKURI的其他文献

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{{ truncateString('MURALI CHERUKURI', 18)}}的其他基金

Functional Magnetic Resonance Imaging for Tumors
肿瘤功能磁共振成像
  • 批准号:
    6558386
  • 财政年份:
  • 资助金额:
    $ 0.16万
  • 项目类别:
Functional Magnetic Resonance Imaging for Tumors in smal
小肿瘤的功能磁共振成像
  • 批准号:
    6756775
  • 财政年份:
  • 资助金额:
    $ 0.16万
  • 项目类别:

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