XENOPUS LINKER PROTEINS

爪蟾连接蛋白

• 批准号: 8365832
• 负责人: Rebecca W Heald
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365832
• 关键词: Binding; Biology; Cells; Characteristics; Development; Elements; Funding; Fungal Genome; Grant; Link; Membrane; Mitosis; Movement; National Center for Research Resources; Organelles; Positioning Attribute; Principal Investigator; Process; Proteins; Proteomics; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Xenopus; base; cost; egg; novel; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Membrane-bound organelles show a characteristic spatial organization and their regulated positioning and movement are key to fundamental processes like mitosis and cell polarization. Disruption of polarity and abnormal cellular organization are linked to the development and progression of cancer. Linker proteins between cytoskeletal elements and organelles are critical for determining cellular organization. We are using a Xenopus egg extract-based proteomics approach to identify novel potential linkers.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 膜结合的细胞器显示出特征性的空间组织，它们的调节定位和运动是有丝分裂和细胞极化等基本过程的关键。极性的破坏和异常的细胞组织与癌症的发展和进展有关。细胞骨架元件和细胞器之间的连接蛋白对于确定细胞组织是至关重要的。我们正在使用基于非洲爪蟾卵提取物的蛋白质组学方法来识别新的潜在接头。