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Determine how telomere dysfunction impacts neuronal function

Determine how telomere dysfunction impacts neuronal function
确定端粒功能障碍如何影响神经元功能
批准号：
10262481
负责人：
Eros Lazzerini Denchi
金额：
$52.22万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10262481
关键词：
AddressAdultAffectAnatomyAnimalsAnxietyArchitectureBiological ModelsBiologyBrainCellsChildClinicalClinical ResearchCutaneousDNA DamageDevelopmentDiseaseDyskeratosis CongenitaFunctional disorderGenesGenetic DiseasesGenetic ModelsGrowthHealthHereditary DiseaseHumanImmunologic Deficiency SyndromesImpairmentIntellectual functioning disabilityKnock-outLaboratoriesLearningLengthLesionLeukoplakiaLongevityMalignant NeoplasmsMemory LossMitoticMolecularMolecular BiologyMusMutationNail plateNeuraxisNeuronsNonhomologous DNA End JoiningPancytopeniaPathway interactionsPhasePlayProcessPsychotic DisordersPubMedPublishingRoleSeizuresSyndromeSystemTP53 geneTelomere MaintenanceTestingWorkchromosome fusioncognitive capacityconditional knockoutdentate gyrusembryonic stem cellexperimental studygenetic approachgranule cellinsightmouse geneticsmouse modelnerve stem cellnestin proteinneurogenesisneuron lossnovelprogenitorresponsetelomere

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英文摘要
Having started my laboratory at NCI in late May 2018 I have been mainly involved in setting up my laboratory. I am currently waiting for the transfer of animals to start this project here at NCI. In my previous laboratory, we have initiated this project and published our initial observation in genes and development: Lobanova A, She R, Pieraut S, Clapp C, Maximov A, Denchi EL. Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons. Genes & development. 2017;31(7):639-47. Epub 2017/04/22. doi: 10.1101/gad.295402.116. PubMed PMID: 28428263; PubMed Central PMCID: PMC5411705.
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Role of TZAP in telomere homoeostasis
  • 批准号：
    9287273
  • 项目类别：
  • 资助金额：
    $38.7万
  • 财政年份：
    2017
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
Development of a Novel System to Capture DNA-associated Proteins
  • 批准号：
    9042991
  • 项目类别：
  • 资助金额：
    $20.93万
  • 财政年份：
    2015
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
Mechanisms of cell fate determination and aging onset upon telomere dysfunction
  • 批准号：
    8186376
  • 项目类别：
  • 资助金额：
    $38.85万
  • 财政年份：
    2011
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
TRF2 INTERACTING PROTEINS
  • 批准号：
    8365840
  • 项目类别：
  • 资助金额：
    $1.28万
  • 财政年份：
    2011
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    UNIVERSITY OF WASHINGTON
海外基金