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Investigate the mechanism of action of the novel telomere length regulator TZAP

Investigate the mechanism of action of the novel telomere length regulator TZAP
研究新型端粒长度调节剂 TZAP 的作用机制
批准号：
10262480
负责人：
Eros Lazzerini Denchi
金额：
$52.22万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10262480
关键词：
AddressAllelesAnimalsBindingCell DeathCellsCohort AnalysisComplexDataData AnalysesFutureGenesGerm CellsGrowthGuide RNAHomeostasisIndividualKnockout MiceLaboratoriesLengthPlayPopulationProcessProteinsResearch InstituteRoleTERF1 geneTimeWorkZinc Fingersbasecancer cellexperimental studygenome-widein vivoinsightnext generation sequencingnovelstem cellstelomeretelomere loss

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英文摘要
Having started my laboratory at NCI in late May 2018 I have been mainly involved in setting up my laboratory. My future work at NCI will be to validate and characterize positive hits identified in the genome-wide gRNA screen described above. These experiments are expected to provide us with mechanistic insights into the role of TZAP and telomere trimming in telomere length homeostasis. In addition, we will analysis of cohorts of TZAP null mice will allow us to establish whether TZAP depletion in vivo leads to progressive telomere elongation and the consequences of critically long telomeres in vivo. I am currently waiting for the transfer of animals to start this project here at NCI.
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Role of TZAP in telomere homoeostasis
  • 批准号：
    9287273
  • 项目类别：
  • 资助金额：
    $38.7万
  • 财政年份：
    2017
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
Development of a Novel System to Capture DNA-associated Proteins
  • 批准号：
    9042991
  • 项目类别：
  • 资助金额：
    $20.93万
  • 财政年份：
    2015
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
Mechanisms of cell fate determination and aging onset upon telomere dysfunction
  • 批准号：
    8186376
  • 项目类别：
  • 资助金额：
    $38.85万
  • 财政年份：
    2011
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
TRF2 INTERACTING PROTEINS
  • 批准号：
    8365840
  • 项目类别：
  • 资助金额：
    $1.28万
  • 财政年份：
    2011
  • 负责人：
    Eros Lazzerini Denchi
  • 依托单位：
    UNIVERSITY OF WASHINGTON
海外基金