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PROJECT A

PROJECT A
项目A
批准号：
8277482
负责人：
Wei Wang
金额：
$36.84万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-01 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8277482
关键词：
AffectAllelesBioinformaticsCpG dinucleotideDNA MethylationDevelopmentDisease susceptibilityEpigenetic ProcessGenerationsGeneticGenetic VariationGenomeGoalsMammalsMapsMusParentsPatternPlayPopulationProcessQuantitative Trait LociRecombinantsRoleSurveysVariantepigenetic variationgene environment interactiongenetic variantgenome-widemammalian genometrait

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中文摘要
翻译
项目A：表观遗传学; Fernando Pardo-Manuel de维莱纳，Wei Wang，伦纳德 麦克米兰 DNA甲基化是一种广泛存在的表观遗传标记，在发育、基因表达和遗传过程中起着关键作用。 环境相互作用和疾病易感性。DNA甲基化是一个高度动态的过程 可能影响哺乳动物基因组中约2000万个CpG二核苷酸。全球和本地DNA 甲基化模式在正常和病理条件下均不同。我们的目标是建立一个全面的 小鼠DNA甲基化变异的图谱，并了解遗传变异在 表观遗传变异
英文摘要
Project A: The Genetics of Epigenetics; Fernando Pardo-Manuel de Villena, Wei Wang, Leonard McMillan (UNC) DNA methylation is a widespread epigenetic mark that plays critical roles in development, gene by environment interaction and disease susceptibility in mammals. DNA methylation is a highly dynamic process that may affect ~20 million CpG dinucleotides present in a mammalian genome. Global and local DNA methylation patterns vary in both normal and pathological conditions. Our goal is to generate a comprehensive map of DNA methylation variation in mouse and to understand the role that genetic variation plays in epigenetic variation.
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Deciphering atomic-level enzymatic activity by time-resolved crystallography and computational enzymology
Deciphering atomic-level enzymatic activity by time-resolved crystallography and computational enzymology
Systems-level identification of key regulators deciding immune cell state
Systems-level identification of key regulators deciding immune cell state
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