US-UK Collab: Understanding the effects of spatial structure on the evolution
US-UK Collab: Understanding the effects of spatial structure on the evolution
批准号:
8642709
负责人:
Jacobus de Roode
金额:
$39.83万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-01 至 2018-07-31
关键词:
AffectAgricultureAnimalsApidaeApisAutomobile DrivingBeesCharacteristicsCross InfectionDevelopmentDiseaseDisease ManagementEpidemiologyEvolutionGuidelinesHealthHeterogeneityHoneyHumanIndividualLaboratoriesLifeMitesModelingOutcomePanthera leoParasitesPlanetsPlantsPlayPoliciesPopulationPractice ManagementProcessProductionRecommendationRelative (related person)ResistanceRoleStructureSystemTestingUniversitiesVariantVirulenceVirulentdesigndisease transmissionferalinsightmortalitypreventprogramsresearch studytheoriestransmission process
中文摘要
理论表明,空间结构在推动毒力进化中至关重要
英文摘要
Theory has shown that spatial structure is crucially important in driving virulence evolution: when
hosts are more likely to transmit disease exclusively to close neighbors (i.e. local transmission),
parasites are expected to evolve lower virulence than when hosts are likely to infect remote
individuals (i.e. global transmission). However, this theory remains untested in a real-life field
system. This proposal takes advantage of honeybees (Apis mellifera) and their destructive
parasitic mites (Varroa destructor) to study the role of spatial structure in virulence evolution.
Varroa mites are the single largest cause of honeybee colony losses worldwide, and beekeeping
practices are likely to drive this parasite's virulence by routinely altering transmission conditions
and population structure. Intensive beekeeping increases global mite transmission and thus has
the potential to unintentionally select for devastating parasites. This proposal has three specific
aims: (1) an experimental evolution study at an unprecedented scale, which will vary the relative
importance of local versus global mite transmission to determine how this affects virulence
evolution; (2) development of virulence evolution models to study the role of spatial structure in
agricultural systems, which will be applied to the honeybee-Varroa system to make specific
recommendations on beekeeping practices to prevent selection of high virulence; and (3) a large
scale cross-infection experiment to test whether current beekeeping practices have selected for
higher virulence, which will compare mites from intensively managed, lightly managed and feral
bees. The combination of large-scale field experiments and theory development on the tractable
system of bees and mites will be powerful in developing important insights in the role of spatial
structure and host heterogeneity in disease transmission, epidemiology and evolution.
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Infectious Diseases Across Scales Training Program
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批准号:10199941
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项目类别:
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资助金额:$19.6万
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财政年份:2019
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负责人:Jacobus de Roode
-
依托单位:
Infectious Diseases Across Scales Training Program
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批准号:9788828
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项目类别:
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资助金额:$9.68万
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财政年份:2019
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负责人:Jacobus de Roode
-
依托单位:
Infectious Diseases Across Scales Training Program
-
批准号:10653012
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项目类别:
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资助金额:$20.06万
-
财政年份:2019
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负责人:Jacobus de Roode
-
依托单位:
Infectious Diseases Across Scales Training Program
-
批准号:10440267
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项目类别:
-
资助金额:$20.9万
-
财政年份:2019
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负责人:Jacobus de Roode
-
依托单位:
US-UK Collab: Understanding the effects of spatial structure on the evolution
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批准号:8724536
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项目类别:
-
资助金额:$29.64万
-
财政年份:2013
-
负责人:Jacobus de Roode
-
依托单位:
US-UK Collab: Understanding the effects of spatial structure on the evolution
-
批准号:9111051
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项目类别:
-
资助金额:$33.09万
-
财政年份:2013
-
负责人:Jacobus de Roode
-
依托单位:
US-UK Collab: Understanding the effects of spatial structure on the evolution
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批准号:9320833
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项目类别:
-
资助金额:$33.47万
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财政年份:2013
-
负责人:Jacobus de Roode
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依托单位:
海外基金