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Pilot Projects

Pilot Projects
试点项目
批准号:
8375834
负责人:
DOUGLAS A LAUFFENBURGER
金额:
$12.28万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-04-17 至 2015-02-28
关键词:
1-Phosphatidylinositol 3-KinaseActinsAddressAffectAntibodiesBehaviorBindingBiological AssayCalibrationCell CommunicationCell physiologyCellsCleaved cellCollaborationsColorCommunitiesComplementComplexComputer SimulationDNA DamageDataDirect CostsDisintegrinsDyesEngineeringEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEventExtracellular Matrix DegradationFeedbackFilmFluorescenceFluorescence MicroscopyFundingGlycogen (Starch) SynthaseGoalsGrantGrowth FactorGrowth Factor ReceptorsHuman ResourcesIn VitroIndividualLaboratoriesMEKsMatrix MetalloproteinasesMeasurementMeasuresMediatingMetalloproteasesMethodsMicroarray AnalysisModelingNatureNeoplasm MetastasisPathway interactionsPeptide HydrolasesPeptidesPhenotypePhospho-Specific AntibodiesPhosphorylationPilot ProjectsPolymersPreclinical Drug EvaluationProcessProgress ReportsProtease InhibitorProtein MicrochipsProteinsProto-Oncogene Proteins c-aktPublishingPyroxylinReagentRecording of previous eventsRelative (related person)ResearchResearch PersonnelSamplingScienceSignal PathwaySignal TransductionSlideSpecificitySpottingsStimulation of Cell ProliferationSubstrate SpecificitySurfaceSystemTechniquesTimeTissuesTumor Cell InvasionU-0126VariantWestern BlottingWorkantibody conjugatebasecell growth regulationcell motilitychemokinecytokinedesignenzyme activityextracellularfluorophoreinhibitor/antagonistinterestkinase inhibitormalignant breast neoplasmmigrationneoplastic cellnovel strategiespolypeptideprogramsresearch studyresponsesensortechnology developmenttherapeutic targettooltumorwortmannin

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N4F. PILOT PROJECTS We typically aim to provide catalytic funding for two Pilot projects during each grant year. Pilot projects are funded for a period of two years at a level in the range of ~$6oK-9oK direct costs per year. The level depends on the extent of personnel and materials/supplies requirement for gaining preliminary results, and the time period permits assessment of how well the science and investigators integrate into the ongoing Projects or Core. The Pilot projects are selected by the Steering Committee from applications submitted by investigators in the MIT (and Harvard) communities, on the basis of potential for providing powerful new approaches that complement overall program aims. If deemed highly successful in collaborative integration, the Pilot investigator(s) can become regular PIs in the Projects or Core. During the previous grant period, Pilots directed by Ernest Fraenkel and Mike Hemann have done so, with results described in the Progress Report section and plans described in the Research Plans section for their corresponding Project and Core participation. The two Pilots intended for Year 6 of the grant if successfully renewed are presented below.
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