Inflammation in Innate and Adaptive Immune Mechanisms

先天性和适应性免疫机制中的炎症

• 批准号: 8400393
• 负责人: Andrea Joan Tenner
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8400393
• 关键词: Academia; Address; Alcohols; Area; Award; B-Lymphocytes; Basic Science; Biology; Cells; Clinical; Clinical Immunology; Collaborations; Communicable Diseases; Cost Sharing; Cytokine Signaling; Dendritic Cells; Development; Disabled Persons; Disease; Environment; Epithelium; Fostering; Funding; Gene Expression; Goals; Hawaii; Health; Human; Immune; Immune system; Immunity; Immunology; Individual; Industry; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Interest Group; Laboratories; Leukocytes; Link; Location; Lymphoid; Malignant Neoplasms; Manufacturer Name; Metabolic Control; Minority; Minority Groups; Myeloid Cells; Natural Immunity; Natural Killer Cells; Neurosciences; Oral; Participant; Pathogenesis; Pattern recognition receptor; Population; Post-Transcriptional Regulation; Productivity; Reagent; Regulation; Regulatory T-Lymphocyte; Request for Proposals; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientific Societies; Scientist; Signal Transduction; Societies; Solutions; T-Lymphocyte; Translational Research; Trauma; Travel; Underrepresented Minority; Woman; Work; abstracting; adaptive immunity; falls; immune activation; innovation; macrophage; meetings; member; novel; pathogen; posters; programs; public health relevance; response; success; symposium; tumor

Description (as provided by the applicant): The annual meeting of Society for Leukocyte Biology, a leading scientific society addressing immune activation by infection or injury and the organization and control of that response, has a tradition of highlighting the most innovative and timely work on the mechanisms underlying host-pathogen interactions, dysregulation as a result of trauma or injury and leukocyte functions in the pathogenesis of disease. The 2012 meeting "Inflammation in Innate and Adaptive Immune Mechanisms" will continue this tradition by bringing together scientific researchers of all levels in an environment geared to maximize interactions and the exchange of ideas. Objective 1. To provide funding to expand the number of individuals that can attend the annual meeting of the Society of Leukocyte Biology, by providing travel awards for trainees and increase the capacity for additional attendees. The meeting is a forum for approximately 300-350 participants from academic, governmental, and industrial laboratories worldwide that will include presentation and discussion of emerging concepts in inflammatory response as they impact on innate and adaptive immunity. These will include (1) identification of new pattern recognition receptors, (2) the role of the epithelium in initiation of inflammatory response and the connection to adaptive immunity, (3) new features of inflammasome function in propagation of inflammatory response, (4) the emerging importance of tumor infiltrating myeloid cells in the link between inflammation and cancer, and (5) the contribution of metabolic controls in lymphoid differentiation and function. The program will feature presentations by invited leaders in the field, as well as poster presentations by junior investigators and trainees and oral presentations selected from among the abstracts submitted by laboratories worldwide. Objective 2. To provide additional scientific programmatic content covering new developments in the regulation, activation and function of the diverse cell populations of the innate and adaptive immune system. This will be accomplished through sessions focused on macrophages and dendritic cells, ?/¿ T cells and NK cells, B cells, and Th17 and Treg cells. In addition, aspects of leukocyte functionality will also be included in the program and will capture new developments in cytokine signaling, post-transcriptional regulation of inflammatory gene expression, host pathogen interactions, and the connection of immunity and neuroscience. A pre-meeting satellite symposium focused on the impact of alcohol on aspects of signaling in inflammation and immunity will be organized by the Alcohol and Immunology Research Interest Group and will occur the day before the opening of the SLB conference. Our meeting will broaden exposure of basic and clinical immunology to the attendees of the satellite meeting. Objective 3. To provide an opportunity for young investigators and trainees to interact closely with well- established researchers in their fields both formally and informally and to present their research in both poster and podium/oral sessions. Objective 4. To provide an opportunity for women, members of under-represented minority groups, and persons with disabilities to participate in a meeting that showcases their work and facilitates one on one interactions with other scientists in their fields, as well as providing a forum to address obstacles and explore solutions that will optimize their success. Public Health Relevance: The scientific advances in the complementary and interactive fields of inflammation, innate immunity, infectious disease and inflammatory disorders continue to accelerate with novel findings and implications for human health. The annual conference of the Society for Leukocyte Biology in 2012 will provide a much needed opportunity for a highly productive exchange of scientific information on the latest advances and best work in these fields, which have enormous relevance to a broad range of clinical disorders currently prevalent in the US and worldwide populations. Moreover, the conference will strongly promote effective interactions among scientists from different fields, between established and developing junior investigators, and with women and minority scientists with the hope of developing productive collaborations and/or accelerating research productivity and success.

描述(由申请人提供)：白细胞生物学学会年会是一个主要的科学学会，致力于通过感染或损伤激活免疫并组织和控制这种反应，传统上强调在宿主-病原体相互作用、创伤或损伤引起的调节失调以及疾病发病机制中的白细胞功能方面最具创新性和最及时的工作。2012年的“先天免疫和适应性免疫机制中的炎症”会议将延续这一传统，将所有级别的科学研究人员聚集在一个旨在最大限度地进行互动和思想交流的环境中。目标1.通过为受训人员提供旅行奖励并增加更多与会者的能力，为扩大可参加白细胞生物学学会年会的个人人数提供资金。这次会议是来自世界各地学术、政府和工业实验室的约300-350名与会者的论坛，将包括介绍和讨论炎症反应中的新概念，因为它们影响先天免疫和获得性免疫。这些将包括(1)新的模式识别受体的鉴定，(2)上皮在启动炎症反应和与适应性免疫的联系中的作用，(3)炎症小体功能在炎症反应的传播中的新特征，(4)肿瘤浸润性髓细胞在炎症和癌症之间联系中的新的重要性，以及(5)代谢控制在淋巴分化和功能中的作用。该方案将包括该领域特邀领导人的陈述，初级调查人员和受训人员的海报陈述，以及从世界各地实验室提交的摘要中挑选出来的口头陈述。目的2.提供额外的科学计划内容，涵盖先天性和获得性免疫系统不同细胞群体的调节、激活和功能方面的新进展。这将通过集中于巨噬细胞和树突状细胞、T细胞和NK细胞、B细胞以及Th17和Treg细胞的会议来完成。此外，白细胞功能的各个方面也将包括在该计划中，并将在细胞因子信号转导、炎症基因表达的转录后调节、宿主病原体相互作用以及免疫和神经科学的联系方面获得新的进展。酒精和免疫学研究兴趣小组将组织一次会议前卫星专题讨论会，重点讨论酒精对炎症和免疫信号传递方面的影响，并将在SLB会议开幕的前一天举行。我们的会议将扩大对卫星会议与会者的基础和临床免疫学的了解。目标3.为青年研究人员和受训人员提供机会，使他们能够与各自领域的知名研究人员进行正式和非正式的密切互动，并在海报和讲台/口头会议上介绍他们的研究成果。目标4.为妇女、任职人数不足的少数群体成员和残疾人提供机会，参加一次展示其工作并促进 一方面，与各自领域的其他科学家进行互动，并提供一个论坛，以解决障碍和探索解决方案，以优化他们的成功。 公共卫生相关性：炎症、先天免疫、传染病和炎症性疾病等互补和互动领域的科学进展继续加快，新的发现和对人类健康的影响。2012年的白细胞生物学学会年会将提供一个非常必要的机会，就这些领域的最新进展和最佳工作进行高效的科学信息交流，这些领域与目前在美国和世界各地流行的一系列临床疾病具有巨大的相关性。此外，会议将大力促进来自不同领域的科学家之间的有效互动，现有和发展中的初级研究人员之间的有效互动，以及与妇女和少数族裔科学家的有效互动，以期发展富有成效的合作和(或)加速研究生产力和成功。