Molecular Imaging in the Treatment of Kaposi's Sarcoma

分子影像治疗卡波西肉瘤

• 批准号: 8566681
• 负责人: RICHARD Frederick AMBINDER
• 金额: $ 17.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8566681
• 关键词: Biometry; Bortezomib; Clinical; Collection; Development; Ensure; Environment; Enzymes; Equipment; Extracellular Matrix; Five-Year Plans; Funding; Future; Goals; Image; Imaging technology; Kaposi Sarcoma; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of pancreas; Mediating; Metastatic Neoplasm to the Bone; Metastatic Prostate Cancer; Modality; Molecular; Neoplasm Metastasis; Oncologist; Pathologist; Pathway interactions; Patients; Positron-Emission Tomography; Radiation; Renal carcinoma; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Structure; Surgeon; Translating; Translations; Treatment Efficacy; Treatment outcome; base; bench to bedside; career development; effective therapy; epithelial to mesenchymal transition; hypoxia inducible factor 1; imaging modality; imaging probe; improved; in vivo Cellular and Molecular Imaging Centers; melanoma; molecular imaging; molecular oncology; oncology; optical imaging; programs; radiologist; single photon emission computed tomography; theranostics; tumor progression

For our next five-year plan we have aligned ourselves to the goals of discovering, developing, and translating molecular imaging technologies to understand, detect, and treat cancer. Our efforts and expertise will be applied collectively and synergistically for this purpose. By engaging and integrating clinical oncologists, radiologists, pathologists, and surgeons within every aspect of the program, we have ensured the translation of our most exciting discoveries to improve treatment outcome in patients. This unique collection of highly interactive research-scientists and clinician-scientists within an environment rich in multi-modality imaging expertise and equipment is necessary to make the catapulting advances and discoveries that are essential to find effective treatments for cancer. The JHU ICMIC Program consists of four research components, four developmental projects, four resources, and a career development component. The four research components have a major emphasis on clinical translation and cover different aspects of understanding, detecting, and treating cancer. These are (i) theranostic imaging of metastatic prostate cancer, (ii) BETR (bortezomib-induced enzyme targeted radiation) theranostics for Kaposi's sarcoma (KS), (iii) exchange transfer-based molecular MRI in oncology and (iv) molecular imaging of the extracellular matrix (ECM) and its avenues for metastasis. Similarly, the four developmental projects cover a range of topics, such as (i) force propagation in melanoma cancer progression, (ii) imaging peri-tumoral stromal depletion as a surrogate for treatment efficacy in pancreatic cancer, (iii) lung-specific Twist mediated epithelial to mesenchymal transition (EMT) in lung premetastatic niche, and (iv) blockade of the hypoxia inducible factor (HIF)-1 pathway in bone metastasis from renal cancer. We have structured four specialized resources (the Administrative Resource, the Molecular Oncology Resource, the Imaging and Probes Resource, and the Biostatistics Resource) to provide the infrastructure to support the current and future projects of the JHU ICMIC. The Career Development Component is structured with the purpose of creating independently funded investigators who will, in the future, become leaders in the field.

在我们的下一个五年计划中，我们将自己与发现、开发和 翻译分子成像技术，以了解，检测和治疗癌症。我们的努力和 为此目的，将集体和协同地运用专门知识。通过参与和整合 临床肿瘤学家，放射科医生，病理学家和外科医生在该计划的各个方面，我们有 确保将我们最激动人心的发现转化为改善患者治疗结果的成果。这 独特的高度互动的研究科学家和临床科学家在一个环境丰富的集合 在多模态成像技术和设备是必要的，以使放射治疗的进步， 对于寻找癌症有效治疗方法至关重要的发现。JHU ICMIC计划包括 四个研究组成部分，四个发展项目，四个资源和职业发展 成分四个研究部分主要强调临床翻译和覆盖 了解、检测和治疗癌症的不同方面。（1）治疗诊断成像： 转移性前列腺癌，（ii）BETR（硼替佐米诱导的酶靶向放射）治疗诊断学， Kaposi肉瘤（KS），（iii）肿瘤学中基于交换转移的分子MRI和（iv）分子 细胞外基质（ECM）及其转移途径的成像。同样，四个发展 项目涵盖一系列主题，如（i）黑色素瘤癌症进展中的力传播，（ii）成像 肿瘤周围基质消耗作为胰腺癌治疗功效的替代物，（iii）肺特异性 扭转介导的肺转移前小生境上皮间质转化（EMT），和（iv）阻断 缺氧诱导因子-1通路在肾癌骨转移中的作用我们构建了 四个专业资源（行政资源，分子肿瘤学资源，成像资源） 和探针资源，以及生物统计资源），以提供基础设施，支持当前的 以及JHU ICMIC的未来项目。职业发展部分的结构是为了 创造独立资助的调查人员，他们将在未来成为该领域的领导者。