Genomics

基因组学

• 批准号: 8555234
• 负责人: Mark D ADAMS
• 金额: $ 17.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-14 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555234
• 关键词: Address; Area; Biostatistics Core; Cancer Center; Colon Carcinoma; Comprehensive Cancer Center; Core Facility; DNA; DNA Sequence; DNA Sequencing Facility; Data; Data Quality; Development; Dideoxy Chain Termination DNA Sequencing; Ensure; Equipment; Esophageal Adenocarcinoma; Faculty; Family member; Formalin; Funding; Gene Expression; Genome; Genomics; Genotype; Goals; Human Resources; Individual; Institutes; Investments; Laboratories; Medical; Methods; Paraffin Embedding; Performance; Persons; Pilot Projects; Process; Records; Research Activity; Research Infrastructure; Research Personnel; Resources; Robotics; Sampling; Services; Specimen; Staging; Standardization; Susceptibility Gene; Technical Expertise; Technology; Tissues; United States National Institutes of Health; Universities; Work; design; flexibility; genetic technology; high throughput analysis; instrumentation; medical schools; medical specialties; meetings; member; next generation; success

The goal of the Genomics Core is to provide comprehensive support for genomic analyses carried out in each of the Case Gl SPORE Projects. The Genomics Core will capitalize on the significant investment in common and shared infrastructure that has been created at CWRU, with support from the School of Medicine, the Case Comprehensive Cancer Center, and the Howard Hughes Medical Institute. CWRU and Cancer Center core resources that are part of this SPORE have been the subject of NIH support and are partially funded as such; thus, this SPORE will be leveraging the existing support to provide each project access to state-of-the-art genome-scale analysis expertise. The Genomics Core builds on exisfing core facilities that have a significant track record of performance and success, as well as the faculty interactions which have supported the initial work for components presented within each Project of this application. The Genomics Core will be a central resource for providing high-throughput genotyping and 'next-generation' DNA sequencing capability for two Projects. In addition, the Core will develop and implement additional methods as necessary to support all Projects, including Pilot Projects. The equipment and personnel available in the Genomics Core support research activities that require instrumentation and expertise that are not available or practical in the laboratories of the individual Project Pis, and for which centralized analyses are required in order to achieve process standardization and economies-of-scale. Specifically, the Genomics Core will perform region-specific DNA capture and high-throughput DNA sequencing and genotyping in support of the individual SPORE Projects. The Genomics Core will work closely with the Specimen and Tissue Core for access to quality assessment of materials for analysis and with the Biostatistics Core for data quality assessment and analysis.

基因组学核心的目标是为在以下领域进行的基因组分析提供全面的支持： 每个案例Gl SPORE项目。基因组学核心将利用在以下方面的重大投资： 通用和共享的基础设施，已在CWRU创建，与学校的支持， 医学，病例综合癌症中心和霍华德休斯医学研究所。CWRU和 癌症中心的核心资源是这个孢子的一部分，一直是美国国立卫生研究院支持的主题， 因此，该SPORE将利用现有支持为每个项目提供 获得最先进的基因组规模分析专业知识。基因组学核心建立在基因组学核心之上 设施，有一个显着的业绩和成功的跟踪记录，以及教师的互动 这些文件支持了本申请的每个项目中提出的组件的初始工作。的 Genomics Core将成为提供高通量基因分型和“下一代”的中心资源。 两个项目的DNA测序能力。此外，核心小组还将制定和实施更多的 支持所有项目，包括试点项目所需的方法。设备和人员 基因组学核心支持需要仪器和专业知识的研究活动， 在各个项目Pis的实验室中不可用或不实用， 需要进行分析，以实现工艺标准化和规模经济。具体而言是 Genomics Core将进行区域特异性DNA捕获和高通量DNA测序， 基因分型，以支持各个SPORE项目。基因组学核心将与 样本和组织芯，用于访问分析材料的质量评估， 生物统计学数据质量评估和分析的核心。