Role of White Matter Integrity in Age-Related Functional Reorganization

白质完整性在年龄相关功能重组中的作用

• 批准号: 8540664
• 负责人: Kristen M. Kennedy
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540664
• 关键词: Adult; Affect; Age; Aging; Aging-Related Process; Area; Award; Bilateral; Brain; Brain region; Cerebrum; Cognition; Cognitive; Cognitive aging; Communication; Complex; Contralateral; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Distant; Doctor of Philosophy; Elderly; Faculty; Fiber; Functional Magnetic Resonance Imaging; Goals; Individual; Individual Differences; Intervention; Judgment; Knowledge; Longevity; Measures; Mediating; Mentors; Modeling; Nature; Parietal; Parietal Lobe; Participant; Pathway interactions; Pattern; Performance; Phase; Plastics; Positioning Attribute; Process; Psyche structure; Public Health; Recruitment Activity; Relative (related person); Research; Research Design; Research Proposals; Role; Sample Size; Sampling; Scientist; Secure; Semantics; Staging; Structure; Synaptic Transmission; Testing; Training; Universities; Work; abstracting; age effect; age group; age related; aged; aging brain; association cortex; cognitive neuroscience; gray matter; indexing; middle age; neural recruitment; neuroimaging; normal aging; novel; phase change; relating to nervous system; response; skills; white matter; young adult

Project Summary/ Abstract The objectives of this Pathway to Independence Award (K99/R00) for Kristen Kennedy, Ph.D., are to expand the candidate's expertise in the field of cognitive neuroscience, to enable her to investigate novel questions regarding the role of white matter integrity in supporting age-related functional reorganization, and to transition successfully to an independent scientist in a tenure-track position at a research university. Combining structural and functional measures of brain integrity is a major goal in the field of the cognitive neuroscience of aging, and knowledge gained from this study should bring us closer to understanding how brain structure affects the brain's functional reorganization and the compensatory nature of that reorganization. The central aim of this project is to investigate the role of white matter structural connectivity in bilateral recruitment and to examine the compensatory nature of this functional reorganization. The hypotheses will be tested in a lifespan sample of adults using Diffusion Tensor Imaging, measures of cognitive performance, and a semantic judgment functional MRI task from which we can measure a bilateral activity index. The specific aims of this proposal are: 1) To test the hypothesis that white matter connectivity governs age-related bilateral recruitment; 2) To combine white matter integrity and cognitive performance to determine the compensatory nature of age-related bilateral recruitment; and 3) To experimentally manipulate task demands to test the hypothesis that white matter connectivity becomes more important in supporting bilateral recruitment as difficulty increases. Because the candidate's ultimate goal is to secure a tenure-track faculty position in a research-oriented university, award of this proposal will facilitate acquiring that position well-prepared for the transition from mentored to independent work and with the professional skills necessary to manage a neuroimaging lab. Lastly, award of this proposal will allow the candidate to prepare and submit a major research proposal (R01) at an earlier stage than would be possible without this K99/R00 mechanism.

项目摘要/摘要 克里斯汀·肯尼迪（Kristen Kennedy，Ph.D.） 候选人在认知神经科学领域的专业知识，使她能够调查有关有关的新问题 白质完整性在支持年龄相关的功能重组中的作用，并成功过渡到 在研究大学的统治地位的独立科学家。结构和功能 大脑完整性的度量是衰老的认知神经科学领域的主要目标， 从这项研究中获得的应该使我们更加了解大脑结构如何影响大脑的功能 重组和重组的补偿性。该项目的核心目的是 研究白质结构连通性在双边募集中的作用并检查补偿性 这种功能重组的性质。假设将在使用成人的寿命样本中进行测试 扩散张量成像，认知性能的度量和语义判断功能MRI任务 我们可以从中测量双边活动指数。该提案的具体目的是：1）测试 白质连通性控制与年龄有关的双边招聘的假设； 2）结合白质 完整性和认知表现，以确定与年龄相关双边招募的补偿性； 3）实验操纵任务要求以检验白质连接性的假设 随着难度增加，在支持双边招聘方面变得越来越重要。因为候选人的 最终目标是确保以研究为导向大学的统治轨道教师职位， 提案将有助于获得从指导到独立的过渡到的过渡 工作以及管理神经影像实验室所需的专业技能。最后，该提议的裁决 将允许候选人在更早的阶段准备并提交一项重大研究建议（R01） 没有这种K99/R00机制。