Role of White Matter Integrity in Age-Related Functional Reorganization

白质完整性在年龄相关功能重组中的作用

• 批准号: 8723718
• 负责人: Kristen M. Kennedy
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723718
• 关键词: Adult; Affect; Age; Aging; Aging-Related Process; Area; Award; Bilateral; Brain; Brain region; Cerebrum; Cognition; Cognitive; Cognitive aging; Communication; Complex; Contralateral; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Distant; Doctor of Philosophy; Elderly; Faculty; Fiber; Functional Magnetic Resonance Imaging; Goals; Individual; Individual Differences; Intervention; Judgment; Knowledge; Longevity; Measures; Mediating; Mentors; Modeling; Nature; Parietal; Parietal Lobe; Participant; Pathway interactions; Pattern; Performance; Phase; Plastics; Positioning Attribute; Process; Psyche structure; Public Health; Recruitment Activity; Relative (related person); Research; Research Design; Research Proposals; Role; Sample Size; Sampling; Scientist; Secure; Semantics; Staging; Structure; Synaptic Transmission; Testing; Training; Universities; Work; abstracting; age effect; age group; age related; aged; aging brain; association cortex; cognitive neuroscience; gray matter; indexing; middle age; neural recruitment; neuroimaging; normal aging; novel; phase change; relating to nervous system; response; skills; white matter; young adult

Project Summary/ Abstract The objectives of this Pathway to Independence Award (K99/R00) for Kristen Kennedy, Ph.D., are to expand the candidate's expertise in the field of cognitive neuroscience, to enable her to investigate novel questions regarding the role of white matter integrity in supporting age-related functional reorganization, and to transition successfully to an independent scientist in a tenure-track position at a research university. Combining structural and functional measures of brain integrity is a major goal in the field of the cognitive neuroscience of aging, and knowledge gained from this study should bring us closer to understanding how brain structure affects the brain's functional reorganization and the compensatory nature of that reorganization. The central aim of this project is to investigate the role of white matter structural connectivity in bilateral recruitment and to examine the compensatory nature of this functional reorganization. The hypotheses will be tested in a lifespan sample of adults using Diffusion Tensor Imaging, measures of cognitive performance, and a semantic judgment functional MRI task from which we can measure a bilateral activity index. The specific aims of this proposal are: 1) To test the hypothesis that white matter connectivity governs age-related bilateral recruitment; 2) To combine white matter integrity and cognitive performance to determine the compensatory nature of age-related bilateral recruitment; and 3) To experimentally manipulate task demands to test the hypothesis that white matter connectivity becomes more important in supporting bilateral recruitment as difficulty increases. Because the candidate's ultimate goal is to secure a tenure-track faculty position in a research-oriented university, award of this proposal will facilitate acquiring that position well-prepared for the transition from mentored to independent work and with the professional skills necessary to manage a neuroimaging lab. Lastly, award of this proposal will allow the candidate to prepare and submit a major research proposal (R01) at an earlier stage than would be possible without this K99/R00 mechanism.

项目摘要/摘要 为克里斯汀·肯尼迪博士颁发的这一独立之路奖(K99/R00)的目标是扩大 应聘者在认知神经科学领域的专业知识，使她能够研究关于 白质完整性在支持与年龄相关的功能重组中的作用，并成功过渡到 在研究型大学担任终身教职的独立科学家。结构和功能相结合 测量大脑的完整性是认知神经科学领域衰老和知识的一个主要目标 从这项研究中获得的成果应该会让我们更深入地了解大脑结构是如何影响大脑功能的 重组和这种重组的补偿性。这个项目的中心目标是 调查白质结构连接在双边招募中的作用，并检查代偿性 这一职能重组的性质。这些假设将在成年人的寿命样本中进行验证，使用 扩散张量成像、认知表现测量和语义判断功能磁共振任务 从中我们可以衡量双边活动指数。这项建议的具体目的是：1)测试 脑白质连接支配年龄相关的双边招募的假说；2)结合脑白质 完整性和认知表现，以确定与年龄有关的双边招聘的补偿性质； 以及3)实验操作任务要求以验证脑白质连接性的假设 随着难度的增加，在支持双边招聘方面变得更加重要。因为候选人的 最终目标是在研究型大学获得终身教职，这一奖项 提议将有助于获得这一职位，为从有指导向独立的过渡做好充分准备 具备管理神经成像实验室所需的专业技能和工作能力。最后，授予这项建议 将允许候选人在更早的阶段准备和提交主要研究提案(R01) 在没有K99/R00机构的情况下是可能的。

项目成果

Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume.

• DOI: 10.1212/wnl.0000000000010868
• 发表时间: 2020-11-03
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Foster CM;Kennedy KM;Daugherty AM;Rodrigue KM
• 通讯作者: Rodrigue KM