Role of White Matter Integrity in Age-Related Functional Reorganization

白质完整性在年龄相关功能重组中的作用

• 批准号: 8073151
• 负责人: Kristen M. Kennedy
• 金额: $ 8.95万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2012-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073151
• 关键词: Adult; Affect; Age; Aging; Aging-Related Process; Area; Award; Bilateral; Brain; Brain region; Cerebrum; Cognition; Cognitive; Cognitive aging; Communication; Complex; Contralateral; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Distant; Doctor of Philosophy; Elderly; Faculty; Fiber; Functional Magnetic Resonance Imaging; Goals; Individual; Individual Differences; Intervention; Judgment; Knowledge; Longevity; Measures; Mediating; Mentors; Modeling; Nature; Parietal; Parietal Lobe; Participant; Pathway interactions; Pattern; Performance; Phase; Plastics; Positioning Attribute; Process; Psyche structure; Public Health; Recruitment Activity; Relative (related person); Research; Research Design; Research Proposals; Role; Sample Size; Sampling; Scientist; Secure; Semantics; Staging; Structure; Synaptic Transmission; Testing; Training; Universities; Work; age effect; age group; age related; aged; aging brain; association cortex; cognitive neuroscience; gray matter; indexing; middle age; neural recruitment; neuroimaging; normal aging; novel; phase change; public health relevance; relating to nervous system; response; skills; white matter; young adult

DESCRIPTION (provided by applicant): The objectives of this Pathway to Independence Award (K99/R00) for Kristen Kennedy, Ph.D., are to expand the candidate's expertise in the field of cognitive neuroscience, to enable her to investigate novel questions regarding the role of white matter integrity in supporting age-related functional reorganization, and to transition successfully to an independent scientist in a tenure-track position at a research university. Combining structural and functional measures of brain integrity is a major goal in the field of the cognitive neuroscience of aging, and knowledge gained from this study should bring us closer to understanding how brain structure affects the brain's functional reorganization and the compensatory nature of that reorganization. The central aim of this project is to investigate the role of white matter structural connectivity in bilateral recruitment and to examine the compensatory nature of this functional reorganization. The hypotheses will be tested in a lifespan sample of adults using Diffusion Tensor Imaging, measures of cognitive performance, and a semantic judgment functional MRI task from which we can measure a bilateral activity index. The specific aims of this proposal are: 1) To test the hypothesis that white matter connectivity governs age-related bilateral recruitment; 2) To combine white matter integrity and cognitive performance to determine the compensatory nature of age-related bilateral recruitment; and 3) To experimentally manipulate task demands to test the hypothesis that white matter connectivity becomes more important in supporting bilateral recruitment as difficulty increases. Because the candidate's ultimate goal is to secure a tenure-track faculty position in a research-oriented university, award of this proposal will facilitate acquiring that position well-prepared for the transition from mentored to independent work and with the professional skills necessary to manage a neuroimaging lab. Lastly, award of this proposal will allow the candidate to prepare and submit a major research proposal (R01) at an earlier stage than would be possible without this K99/R00 mechanism. PUBLIC HEALTH RELEVANCE: The present proposal seeks to provide new knowledge to the field of cognitive neuroscience of aging by examining brain structure and function in the same individuals to allow the study of one to inform understanding of the other. Combining these measures of brain integrity is a major goal in this field and knowledge gained from this study should bring us closer to understanding how brain structure affects the brain's function. Importantly, we are beginning to realize that the aging brain is more plastic and malleable to functional reorganization than previously believed and there is building evidence that this reorganization in older adults is invoked to support better cognitive performance. The goal of the present proposal is to further understand this promising process, and ultimately the functional reorganization patterns seen in older adults, once deemed beneficial, can be studied as a potential cognitive intervention for older adults to maintain good cognitive performance to develop training tasks that produce this pattern in lower-functioning older adults. Extending the cognitively healthy years toward the end of the lifespan would have significant public health implications.

描述（由申请人提供）：为克里斯汀·肯尼迪（Kristen Kennedy）博士提供的这一独立途径奖的目标（K99/R00）是为了扩大候选人在认知神经科学领域的专业知识，以使她能够调查有关白质完整性在支持年龄相关的重建大学和一项独立研究中的独立科学领域的新型问题，并在一项独立的研究中，从事独立的科学领域的角色。结合大脑完整性的结构和功能度量是衰老的认知神经科学领域的主要目标，以及从这项研究中获得的知识，应该使我们更加了解大脑结构如何影响大脑的功能重组以及该重组的补偿性。该项目的核心目的是研究白质结构连通性在双边募集中的作用，并检查这种功能重组的补偿性。这些假设将在成年人的寿命样本中使用扩散张量成像，认知性能的度量以及语义判断功能性MRI任务进行测试，我们可以从中测量双边活动指数。该提案的具体目的是：1）检验以下假设：白质连通性控制与年龄有关的双边招募； 2）结合白质完整性和认知表现，以确定与年龄相关的双边招募的补偿性； 3）要通过实验操纵任务要求，以检验以下假设：随着困难的增加，白质连通性在支持双边招募方面变得越来越重要。因为候选人的最终目标是在以研究为导向的大学中确保终身轨道教师职位，因此该提案的奖励将有助于获得从指导到独立工作的过渡到独立工作以及管理神经影像实验室所需的专业技能的充分准备的职位。最后，该提案的裁决将使候选人能够在没有这种K99/R00机制的情况下在更早的阶段准备和提交一项重大研究建议（R01）。 公共卫生相关性：本提案旨在通过检查同一个人的大脑结构和功能，以允许对另一个人的了解来了解衰老的认知神经科学领域。结合这些大脑完整性的衡量标准是该领域的主要目标，从这项研究中获得的知识应该使我们更加了解大脑结构如何影响大脑的功能。重要的是，我们开始意识到，衰老的大脑比以前认为的更具塑性和可延展性，并且有建筑证据表明，在老年人中调用这种重组以支持更好的认知表现。本提案的目的是进一步理解这一有希望的过程，最终可以研究老年人在老年人中看到的功能重组模式，可以作为对老年人保持良好认知绩效的潜在认知干预措施，以制定训练任务，以开发培训任务，从而在低功能老年人中产生这种模式。将认知健康的岁月延长到寿命末期，将对公共卫生产生重大影响。

项目成果

Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.

• DOI: 10.1093/cercor/bhaa243
• 发表时间: 2021-01-01
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Boylan MA;Foster CM;Pongpipat EE;Webb CE;Rodrigue KM;Kennedy KM
• 通讯作者: Kennedy KM

Frontostriatal white matter connectivity: age differences and associations with cognition and BOLD modulation.

额纹状体白质连接：年龄差异以及与认知和 BOLD 调节的关联。

• DOI: 10.1016/j.neurobiolaging.2020.05.014
• 发表时间: 2020
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Webb,ChristinaE;Hoagey,DavidA;Rodrigue,KarenM;Kennedy,KristenM
• 通讯作者: Kennedy,KristenM

Increasing beta-amyloid deposition in cognitively healthy aging predicts nonlinear change in BOLD modulation to difficulty.

• DOI: 10.1016/j.neuroimage.2018.08.017
• 发表时间: 2018-12
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Kennedy KM;Foster CM;Rodrigue KM
• 通讯作者: Rodrigue KM

Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in an adult lifespan sample.

成人寿命样本中视觉空间难度增量增加的功能磁共振成像数据。

• DOI: 10.1016/j.dib.2017.01.004
• 发表时间: 2017
• 期刊: Data in brief
• 影响因子: 1.2
• 作者: Kennedy,KristenM;Rieck,JennyR;Boylan,MariaA;Rodrigue,KarenM
• 通讯作者: Rodrigue,KarenM

Motion-related artifacts in structural brain images revealed with independent estimates of in-scanner head motion.

• DOI: 10.1002/hbm.23397
• 发表时间: 2017-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Savalia, Neil K.;Agres, Phillip F.;Chan, Micaela Y.;Feczko, Eric J.;Kennedy, Kristen M.;Wig, Gagan S.
• 通讯作者: Wig, Gagan S.