Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course

描述(由申请人提供)：本申请描述了一个为期5年的有指导的培训计划，旨在发展儿童和青少年精神病学的研究生涯，重点是改进定义儿童双相情感障碍的表型方法。首席调查员已经完成了儿童和青少年精神病学的医学博士和住院医师培训。他现在将在分类学方法、多信息者评估、家族和双胞胎设计以及潜变量模型方面获得专业知识。作为主要赞助商，James Hudziak博士将指导国际和平组织的科学发展。Hudziak博士是分类学方法方面的专家，他使用家庭研究和双胞胎研究行为基因设计，并结合发展精神病理学的潜在变量测量方法。该培训项目将由阿姆斯特丹Vrije大学教授、国际知名的双胞胎研究专家Dorret Boomsma博士和佛蒙特州大学教授Thomas Achenbach博士共同赞助。此外，三位国际知名科学家Frank Verhulst博士、Ellen Leibenluft和Michael Neale将提供科学咨询。研究将集中在对经常被诊断为患有儿童双相情感障碍和相关严重情感、行为和认知失调的儿童的诊断方法上。培训和研究将强调使用基于需求侧管理的分类方法，并将它们与基于CBCL的定量方法进行比较。拟议的研究将结合和对比DSM和量化措施，以促进对高度问题青年的理解。对于这一应用，新提出的研究项目允许测试DSM和定量测量之间的关系、DSM和定量定义的熟悉度、方法之间的重叠以及基于CBCL的表型在纵向、遗传信息设计中的结构有效性。这项研究的长期目标是为有严重调节障碍问题的儿童开发更精细的表型方法，这些儿童可能符合或可能不符合儿童双相情感障碍的狭义DSM标准。如果实现了这些方法，这些方法就可以用于基因、神经成像和治疗研究，旨在减轻患有这些疾病的儿童和家庭承受的痛苦负担。公共卫生相关性：通过对注意力、情绪波动和攻击性严重问题的儿童进行特征描述，我希望确定可改变的遗传和环境因素，以减少青春期和成年期的抑郁、人格障碍和药物使用。我希望增加对儿童的看法，他们被称为双相患者，但他们可能患有不同于成人双相情感障碍的障碍，可能需要不同的治疗。

DESCRIPTION (provided by applicant): This application describes a 5 year mentored training program to develop a research career in Child and Adolescent Psychiatry focused on improving phenotypic approaches to defining pediatric bipolar disorder. The principal investigator has completed M.D., Ph.D. and residency training in child and adolescent psychiatry. He will now gain expertise in taxonomic approaches, multi-informant assessment, family and twin designs, and latent variable models. As primary sponsor, Dr. James Hudziak will mentor the Pi's scientific development. Dr. Hudziak is an expert in taxonomic approaches using family study and twin study behavioral genetic designs in concert with latent variable measures to developmental psychopathology. The training program will enlist the co-sponsorship of Dr. Dorret Boomsma, Professor at the Vrije University of Amsterdam and internationally known expert on twin studies and Dr. Thomas Achenbach, Professor at the University, of Vermont. In addition, three internationally-renowned scientists, Drs. Frank Verhulst, Ellen Leibenluft and Michael Neale will provide scientific consultation. Research will focus on diagnostic approaches to children often diagnosed as having pediatric bipolar disorder and related severe dysregulation in affect, behavior and cognition. The training and research will emphasize the use of categorical DSM-based approaches and compare them to quantitative CBCL- based approaches. The proposed studies will combine and contrast DSM and quantitative measures in order to advance the understanding of highly troubled youth. New to this application are proposed research projects allowing for testing of the relations between DSM and quantitative measures, the familiality of DSM and quantitative definitions, the overlap between the approaches, and the construct validity of CBCL-based phenotyping in longitudinal, genetically informative designs. The long term goal of this research is to develop more refined phenotypic approaches for children with severe problems in dysregulation who may or may not meet narrowly defined DSM criteria for pediatric bipolar disorder. If realized, these approaches can then be used in genetic, neuroimaging, and treatment studies aimed at reducing the burden of suffering that children and families with these disorders endure. PUBLIC HEALTH RELEVANCE: By characterizing children with profound problems with attention, mood swings, and aggression I hope to identify modifiable genetic and environmental factors to reduce depression, personality disorders and substance use in adolescence and adulthood. I hope to add perspective on children who are called "bipolar" but who likely have a disorder different from adult bipolar disorder and may need different treatments.