Shared Mechanisms in Child Dysregulation, Adult Psychopath, & Metabolic Diso...
儿童失调、成人精神病患者的共同机制
基本信息
- 批准号:9324319
- 负责人:
- 金额:$ 21.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdolescent PsychiatryAdultAffectAutonomic nervous systemBehaviorBehavioralBehavioral MechanismsBehavioral ResearchBehavioral SymptomsBiologicalCenters of Research ExcellenceChildChild PsychiatryChildhoodChronicClinicCoupledDataDecision MakingDevelopmentDiabetes MellitusDiseaseDoctor of MedicineDoctor of PhilosophyDyslipidemiasEnvironmentEnvironmental ImpactEpigenetic ProcessFamilyFamily StudyFamily history ofFamily memberFrustrationGenesGeneticGenetic Predisposition to DiseaseGenetic ResearchGenomeGlucocorticoidsHealthHypertensionImpairmentImpulsivityIndividualInformal Social ControlInstructionInsulin ResistanceInterventionLeadMeasurementMeasuresMediatingMental disordersMentorsMetabolicMetabolic syndromeMethodsModelingModificationMorbidity - disease rateNR3C1 geneNational Institute of Mental HealthNeurosciences ResearchObesityOutcomeParentsPatternPreventive InterventionPrincipal InvestigatorPsychopathPsychopathologyPsychophysiologyResearchResearch Domain CriteriaRiskRoleStrategic PlanningSubstance Use DisorderSubstance abuse problemSyndromeSystemTestingTrainingVermontWorkbasediscountdiscountingexecutive functionheart rate variabilitylow socioeconomic statusmortalitypreventprobandprogramspromoterresponsestress reactivitytherapy design
项目摘要
PROJECT SUMMARY (See instructions): This proposal describes a 3 year program to investigate the relations between childhood dysregulation and adult substance abuse, psychopathology, and metabolic syndrome. In this COBRE Project the junior principal investigator, an M.D., Ph.D. with training in child and adolescent psychiatry will work with primary mentor James Hudziak, MD, senior mentors Hugh Garavan, MD and Phil Ades, MD to investigate the metabolic, epigenetic, executive function/decision-making, and psychophysiological mechanisms of a child behavioral syndrome termed "dysregulation." The study proposes that dysregulation is a common prodrome for a variety of negative adult outcomes (substance abuse, persistent psychopathology, and the cluster of non-psychiatric disorders referred to as "Metabolic Syndrome" (MS) - diabetes, dyslipedemia, hypertension, and obesity. We propose a model consisting of environmental impact (e.g., low socioeconomic status, chronic adversity) on a genetic predisposition (e.g., family history of self-regulatory problems) affecting the systems involved in self-regulation. The dysregulatory effects in turn affect gluocorticoid and autonomic nervous system (e.g., heart rate variability) responses. We will test this model through the use of a family study approach. In order to do this work, we propose adding measurement of metabolic, epigenetic, executive function/decision-making, and psychophysiological data to parents of children in an ongoing family study of children with dysregulation (NIMH K08MH082116). Through the course of the 3 year study, we will determine the rates of substance use disorders, psychopathology, and metabolic syndrome in the families of children with dysregulation. We will determine the rates of delay discounting (a measure of impulsivity) and the levels of heart rate variability (a measure of autonomic stability) in these children and their families. Using two complementary methods, we will determine the epigenetic profiles in dysregulated children and their family members in two gene promoters known to be associated withs stress reactivity (NR3C1 and FKBP5).
项目总结(见说明):本提案描述了一个为期3年的项目,旨在调查儿童期失调与成人药物滥用、精神病理学和代谢综合征之间的关系。在这个COBRE项目中,初级首席研究员,一个医学博士,博士在儿童和青少年精神病学培训将与初级导师詹姆斯Hudziak,医学博士,高级导师休Garavan,医学博士和菲尔Ades,医学博士研究代谢,表观遗传,执行功能/决策,和心理生理机制的儿童行为综合征称为“失调”。该研究提出,失调是各种负面成人结果的常见前驱症状(药物滥用,持续的精神病理学和称为“代谢综合征”(MS)的非精神疾病群-糖尿病,血脂异常,高血压和肥胖症。我们提出了一个模型,包括环境影响(例如,低社会经济地位,慢性逆境)对遗传易感性(例如,自我监管问题的家族史)影响涉及自我监管的系统。调节异常效应进而影响糖皮质激素和自主神经系统(例如,心率变异性)反应。我们将通过使用家庭研究方法来测试这个模型。为了做这项工作,我们建议增加测量代谢,表观遗传,执行功能/决策,和心理生理数据的儿童的父母在一个正在进行的家庭研究的儿童失调(NIMH K 08 MH 082116)。通过为期3年的研究,我们将确定物质使用障碍,精神病理学和代谢综合征的比例在家庭的儿童失调。我们将确定这些儿童及其家庭的延迟折扣率(冲动性的测量)和心率变异性水平(自主稳定性的测量)。使用两种互补的方法,我们将确定在失调的儿童和他们的家庭成员在两个基因启动子已知与应激反应(NR 3C 1和FKBP 5)的表观遗传概况。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert Russell Althoff其他文献
Robert Russell Althoff的其他文献
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{{ truncateString('Robert Russell Althoff', 18)}}的其他基金
Evaluating the Comparative Validity and Reliability of SERAS: A Decision Support Tool for Assessing Near Term Risk of Suicide in Emergency Departments.
评估 SERAS 的比较有效性和可靠性:用于评估急诊科近期自杀风险的决策支持工具。
- 批准号:
10426286 - 财政年份:2017
- 资助金额:
$ 21.06万 - 项目类别:
Evaluating the Comparative Validity and Reliability of SERAS: A Decision Support Tool for Assessing Near Term Risk of Suicide in Emergency Departments.
评估 SERAS 的比较有效性和可靠性:用于评估急诊科近期自杀风险的决策支持工具。
- 批准号:
10080070 - 财政年份:2017
- 资助金额:
$ 21.06万 - 项目类别:
Evaluating the Comparative Validity and Reliability of SERAS: A Decision Support Tool for Assessing Near Term Risk of Suicide in Emergency Departments.
评估 SERAS 的比较有效性和可靠性:用于评估急诊科近期自杀风险的决策支持工具。
- 批准号:
10197836 - 财政年份:2017
- 资助金额:
$ 21.06万 - 项目类别:
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course
儿童行为检查表-失调概况:基因、环境、
- 批准号:
8288190 - 财政年份:2009
- 资助金额:
$ 21.06万 - 项目类别:
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course
儿童行为检查表-失调概况:基因、环境、
- 批准号:
8464271 - 财政年份:2009
- 资助金额:
$ 21.06万 - 项目类别:
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course
儿童行为检查表-失调概况:基因、环境、
- 批准号:
7741053 - 财政年份:2009
- 资助金额:
$ 21.06万 - 项目类别:
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course
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- 批准号:
8101021 - 财政年份:2009
- 资助金额:
$ 21.06万 - 项目类别:
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course
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- 批准号:
7921678 - 财政年份:2009
- 资助金额:
$ 21.06万 - 项目类别:
Shared Mechanisms in Child Dysregulation, Adult Psychopath, & Metabolic Diso...
儿童失调、成人精神病患者的共同机制
- 批准号:
8734446 - 财政年份:
- 资助金额:
$ 21.06万 - 项目类别:
Shared Mechanisms in Child Dysregulation, Adult Psychopath, & Metabolic Diso...
儿童失调、成人精神病患者的共同机制
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8464941 - 财政年份:
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$ 21.06万 - 项目类别:
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