Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course

描述（由申请人提供）：本申请描述了一项为期 5 年的指导培训计划，旨在发展儿童和青少年精神病学的研究生涯，重点是改进定义儿科双相情感障碍的表型方法。主要研究者已完成医学博士、博士学位。以及儿童和青少年精神病学的住院医师培训。他现在将获得分类学方法、多信息评估、家族和双胞胎设计以及潜变量模型方面的专业知识。作为主要赞助商，James Hudziak 博士将指导 Pi 的科学发展。 Hudziak 博士是分类学方法方面的专家，该方法使用家庭研究和双胞胎研究行为遗传设计以及发展精神病理学的潜在变量测量。该培训项目将得到阿姆斯特丹自由大学教授、国际知名双胞胎研究专家 Dorret Boomsma 博士和佛蒙特大学教授 Thomas Achenbach 博士的共同赞助。此外，三位国际知名科学家 Drs. Frank Verhulst、Ellen Leibenluft 和 Michael Neale 将提供科学咨询。研究将重点关注经常被诊断为患有儿科双相情感障碍以及相关的情感、行为和认知严重失调的儿童的诊断方法。培训和研究将强调基于 DSM 的分类方法的使用，并将其与基于 CBCL 的定量方法进行比较。拟议的研究将结合和对比 DSM 和定量测量，以增进对高度陷入困境的青少年的了解。该应用的新内容是拟议的研究项目，允许测试 DSM 和定量测量之间的关系、DSM 和定量定义的熟悉性、方法之间的重叠以及纵向遗传信息设计中基于 CBCL 的表型分析的构造有效性。这项研究的长期目标是为患有严重失调问题的儿童开发更精细的表型方法，这些儿童可能符合也可能不符合狭义的 DSM 小儿双相情感障碍标准。如果实现的话，这些方法可以用于遗传、神经影像和治疗研究，旨在减轻患有这些疾病的儿童和家庭所承受的痛苦负担。

DESCRIPTION (provided by applicant): This application describes a 5 year mentored training program to develop a research career in Child and Adolescent Psychiatry focused on improving phenotypic approaches to defining pediatric bipolar disorder. The principal investigator has completed M.D., Ph.D. and residency training in child and adolescent psychiatry. He will now gain expertise in taxonomic approaches, multi-informant assessment, family and twin designs, and latent variable models. As primary sponsor, Dr. James Hudziak will mentor the Pi's scientific development. Dr. Hudziak is an expert in taxonomic approaches using family study and twin study behavioral genetic designs in concert with latent variable measures to developmental psychopathology. The training program will enlist the co-sponsorship of Dr. Dorret Boomsma, Professor at the Vrije University of Amsterdam and internationally known expert on twin studies and Dr. Thomas Achenbach, Professor at the University, of Vermont. In addition, three internationally-renowned scientists, Drs. Frank Verhulst, Ellen Leibenluft and Michael Neale will provide scientific consultation. Research will focus on diagnostic approaches to children often diagnosed as having pediatric bipolar disorder and related severe dysregulation in affect, behavior and cognition. The training and research will emphasize the use of categorical DSM-based approaches and compare them to quantitative CBCL- based approaches. The proposed studies will combine and contrast DSM and quantitative measures in order to advance the understanding of highly troubled youth. New to this application are proposed research projects allowing for testing of the relations between DSM and quantitative measures, the familiality of DSM and quantitative definitions, the overlap between the approaches, and the construct validity of CBCL-based phenotyping in longitudinal, genetically informative designs. The long term goal of this research is to develop more refined phenotypic approaches for children with severe problems in dysregulation who may or may not meet narrowly defined DSM criteria for pediatric bipolar disorder. If realized, these approaches can then be used in genetic, neuroimaging, and treatment studies aimed at reducing the burden of suffering that children and families with these disorders endure.