Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life Course

描述（由申请人提供）：本申请描述了一项为期5年的指导培训计划，旨在发展儿童和青少年精神病学的研究事业，重点是改善定义儿科双相情感障碍的表型方法。主要研究者已完成医学博士学位，博士以及儿童和青少年精神病学的住院医师培训。他现在将获得分类方法，多信息评估，家庭和双胞胎设计以及潜变量模型的专业知识。作为主要赞助商，James Hudziak博士将指导Pi的科学发展。Hudziak博士是使用家族研究和双胞胎研究行为遗传设计的分类方法的专家，并与发展精神病理学的潜变量措施相一致。该培训方案将争取阿姆斯特丹自由大学教授、国际知名的双胞胎研究专家Dorret Boomsma博士和佛蒙特大学教授托马斯Achenbach博士的共同赞助。此外，三位国际知名科学家Frank Verhulst博士、Ellen Leibenluft博士和Michael Neale博士将提供科学咨询。研究将集中在诊断方法，以儿童往往被诊断为患有儿童双相情感障碍和相关的严重失调的影响，行为和认知。培训和研究将强调使用基于DSM的分类方法，并将其与基于CBCL的定量方法进行比较。拟议的研究将联合收割机和对比DSM和定量措施，以促进对高度问题青年的理解。新的应用程序提出的研究项目，允许测试DSM和定量措施之间的关系，DSM和定量定义的熟悉度，方法之间的重叠，以及基于CBCL的表型在纵向，遗传信息设计的结构有效性。本研究的长期目标是为有严重失调问题的儿童开发更精细的表型方法，这些儿童可能符合或不符合儿童双相情感障碍的狭义DSM标准。如果实现，这些方法可以用于遗传学，神经影像学和治疗研究，旨在减轻患有这些疾病的儿童和家庭所承受的痛苦负担。

DESCRIPTION (provided by applicant): This application describes a 5 year mentored training program to develop a research career in Child and Adolescent Psychiatry focused on improving phenotypic approaches to defining pediatric bipolar disorder. The principal investigator has completed M.D., Ph.D. and residency training in child and adolescent psychiatry. He will now gain expertise in taxonomic approaches, multi-informant assessment, family and twin designs, and latent variable models. As primary sponsor, Dr. James Hudziak will mentor the Pi's scientific development. Dr. Hudziak is an expert in taxonomic approaches using family study and twin study behavioral genetic designs in concert with latent variable measures to developmental psychopathology. The training program will enlist the co-sponsorship of Dr. Dorret Boomsma, Professor at the Vrije University of Amsterdam and internationally known expert on twin studies and Dr. Thomas Achenbach, Professor at the University, of Vermont. In addition, three internationally-renowned scientists, Drs. Frank Verhulst, Ellen Leibenluft and Michael Neale will provide scientific consultation. Research will focus on diagnostic approaches to children often diagnosed as having pediatric bipolar disorder and related severe dysregulation in affect, behavior and cognition. The training and research will emphasize the use of categorical DSM-based approaches and compare them to quantitative CBCL- based approaches. The proposed studies will combine and contrast DSM and quantitative measures in order to advance the understanding of highly troubled youth. New to this application are proposed research projects allowing for testing of the relations between DSM and quantitative measures, the familiality of DSM and quantitative definitions, the overlap between the approaches, and the construct validity of CBCL-based phenotyping in longitudinal, genetically informative designs. The long term goal of this research is to develop more refined phenotypic approaches for children with severe problems in dysregulation who may or may not meet narrowly defined DSM criteria for pediatric bipolar disorder. If realized, these approaches can then be used in genetic, neuroimaging, and treatment studies aimed at reducing the burden of suffering that children and families with these disorders endure.