Clinical Research in Eating Disorders and Obesity

饮食失调和肥胖的临床研究

• 批准号: 8240551
• 负责人: Denise Ella Wilfley
• 金额: $ 16.49万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8240551
• 关键词: Adolescence; Adolescent; Adult; Anorexia Nervosa; Area; Award; Behavior Therapy; Behavioral; Binge eating disorder; Body Weight decreased; Child; Chronic; Clinical; Clinical Research; Communities; Comorbidity; Controlled Study; DSM-IV; Data; Data Set; Death Rate; Development; Diagnosis; Disease; Early treatment; Eating; Eating Behavior; Eating Disorders; Educational process of instructing; Effectiveness; Ensure; Evaluation; Evidence based treatment; Faculty; Family; Family dynamics; Family psychotherapy; Female; Female Adolescents; Fluoxetine; Funding; Genetic; Goals; High Risk Woman; Incidence; Instruction; Internet; Intervention; Investigation; Label; Life; Maintenance; Manuscripts; Mental Health; Mentors; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Moods; Morbidity - disease rate; National Institute of Mental Health; Neurotransmitters; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Parents; Participant; Pathway interactions; Patients; Peer Review; Pharmaceutical Preparations; Phase; Placebos; Play; Postdoctoral Fellow; Prevention; Prevention approach; Preventive Intervention; Public Health; Publishing; Randomized; Relapse; Relative (related person); Research; Research Design; Research Personnel; Research Support; Resistance; Resources; Risk Factors; Role; Running; Science; Serotonin; Site; Staging; System; Testing; Time; Training Activity; Translational Research; United States National Institutes of Health; Weight; Weight Gain; Woman; Work; abstracting; aged; base; career development; control trial; disability; doctoral student; effective intervention; effective therapy; feeding; follow-up; high risk; improved; meetings; mortality; neuroimaging; next generation; novel strategies; obesity in children; prevent; programs; psychogenetics; psychologic; response; social; therapy design; treatment site; treatment trial; university student

DESCRIPTION (provided by applicant): The public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for a competitive renewal of an NIMH Midcareer Investigator Award in Patient Oriented Research (K24) in order to relieve Dr. Wilfley from clinical, administrative, and teaching duties, to ensure protected time to: 1) Continue developing and improving efficacious treatments for eating and weight disorders that are informed by advancements in the basic behavioral and biomedical sciences; 2) Apply scientific implementation methodology to the deployment of evidence-based treatments for eating and weight disorders into the community; 3) Focus on the prevention and early intervention of eating and weight disorders to prevent comorbidity, relapse, and disability; and 4) Engage in teaching and training activities that will help produce the next generation of clinical researchers in the area of eating disorders and obesity. During the present award period, Dr. Wilfley has successfully concluded three NIH-funded R01s, launched two NIH-sponsored awards, and has two more NIH clinical research trials pending. Her studies have identified effective interventions for a subset of women at high risk for developing eating disorders, for the treatment of binge eating disorder, and for childhood obesity. Also, during this time, she has published over 45 peer-reviewed manuscripts, and mentored 17 pre- and post- doctoral students, and junior faculty. Selected ongoing and pending awards include studies designed to test early interventions for adolescents with anorexia nervosa, an enhanced prevention approach for women at very high risk for developing eating disorders, and methods for maintaining weight loss in children over the long-term. This application describes career development goals for Dr. Wilfley to enhance her expertise in the areas of translational research, specifically to bridge the gap from treatment design and refinement to the implementation and deployment of treatments in the community. She plans to enhance her understanding of neuroimaging and psychiatric genetics to facilitate the development of novel strategies for diagnosis, prevention, and treatment of eating and weight related disorders and to augment her mentoring resources. RELEVANCE (See instructions): Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required. Ensuring that effective treatments are disseminated to the community and reach the patients for whom they are intended is imperative.

描述（由申请人提供）：饮食失调和肥胖对公共卫生的重要性已有充分记录，但已知这些问题难以治疗。本申请是对以患者为导向的研究 (K24) 领域的 NIMH 中期职业调查员奖的竞争性续展请求，以解除 Wilfley 博士的临床、行政和教学职责，以确保有受保护的时间： 1) 继续开发和改进针对饮食和体重障碍的有效治疗方法，这些方法以基本行为和生物医学科学的进步为基础； 2) 应用科学的实施方法，在社区中部署针对饮食和体重失调的循证治疗方法； 3）重点关注饮食和体重失调的预防和早期干预，以防止合并症、复发和致残； 4) 参与教学和培训活动，以帮助培养饮食失调和肥胖领域的下一代临床研究人员。在目前的奖励期内，Wilfley 博士已成功完成了三项 NIH 资助的 R01 项目，启动了两项 NIH 资助的奖项，还有两项 NIH 临床研究试验正在等待中。她的研究为一部分饮食失调高风险女性确定了有效的干预措施，用于治疗暴食症和儿童肥胖症。此外，在此期间，她还发表了超过 45 篇经过同行评审的手稿，并指导了 17 名博士前和博士后以及初级教师。选定的正在进行和悬而未决的奖项包括旨在测试对患有神经性厌食症的青少年进行早期干预的研究，针对饮食失调风险极高的女性的强化预防方法，以及长期维持儿童体重减轻的方法。该申请描述了 Wilfley 博士的职业发展目标，以增强她在转化研究领域的专业知识，特别是弥合从治疗设计和完善到社区治疗实施和部署的差距。她计划加强对神经影像学和精神遗传学的理解，以促进诊断、预防和治疗饮食和体重相关疾病的新策略的开发，并增加她的指导资源。相关性（参见说明）：鉴于与饮食失调和肥胖相关的高发病率和死亡率，需要不断完善治疗方法并注重早期干预和预防。确保有效的治疗方法传播到社区并惠及目标患者至关重要。