Molecular signatures associated with prostatic inflammation in rodent models.
啮齿动物模型中与前列腺炎症相关的分子特征。
基本信息
- 批准号:8566145
- 负责人:
- 金额:$ 24.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-28 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:ATP ReceptorsAdvisory CommitteesAffectAfferent NeuronsAndrogen ReceptorAndrogensAnimal ModelAwardBenignBenign Prostatic HypertrophyBladderBladder DysfunctionCapsaicinCharacteristicsCollaborationsCommunitiesComplexDiseaseDoseElderly manEndocrinologyEpithelialEpithelial CellsFormalinFormalin TestsFunctional disorderFundingFutureGene ExpressionGenesHomeostasisHumanInflammationInflammatoryInjection of therapeutic agentInterdisciplinary StudyLeadMedicalMesenchymalModelingMolecularMolecular AnalysisMolecular ProfilingP2X-receptorPathogenesisPathologyPharmacologyPhysiologicalPreventionPreventiveProductionProstateProstaticProstatic TissueRattusResearchResearch PersonnelResearch Project GrantsResourcesRodentRodent ModelRoleSignal PathwaySocietiesSpecimenTNFRSF5 geneTestingTestosteroneTherapeuticTissuesUniversitiesUp-RegulationUrinationUrineUrologyWorkagedchemokineclinically significantcostcytokinelower urinary tract symptomsmenmultidisciplinarynovelprogramsresearch studysuccess
项目摘要
This competing renewal application from the University of Pittsburgh Planning Center for Interdisciplinary
Research in Benign Urology (IR-BU) is proposed to study "Molecular signatures associated with prostatic
inflammation in rodent models". Because of the importance of inflammation in BPH, a team of investigators
with different expertise including endocrinology, pathology, urology, and pharmacology will work together to
determine similarities and dissimilarities in inflammation-induced molecular and cellular changes in and/or
outside the prostate between rodents and humans in this multidisciplinary project. The research hypothesis
is that prostatic inflammation can induce molecular and cellular changes associated with human BPH. This
hypothesis is supported by the finding during the current funding period that formalin-induced low grade
inflammation enhanced expression of androgen-responsive genes in the formalin-injection rat prostate model
and our previous finding that androgen-responsive gene expression is elevated in human BPH epithelial
cells. Using formalin-induced rat prostate inflammation as a model, we propose to determine the effect of
prostatic inflammation on bladder and afferent function (Specific Aim 1), inflammatory cytokine profile in the
prostate and urine (Specific Aim 2), and prostatic epithelial-mesenchymal transition (Specific Aim 3). The
success of this research project will identify relevant targets and signaling pathways in rodents that respond
to inflammation to generate altered prostate tissue homeostasis characteristic of BPH in humans.
The IR-BU has established an Administrative Core, which includes an Executive Committee and an Internal
Advisory Committee, will provide strong administrative support through project review, promoting
collaborations, and educational enrichment. The Core will also be responsible for allocation and oversight of
IR-BU resources. Through supporting the educational enrichment and research project, the Administrative
Core will help to both integrate the IR-BU into the University community by serving as a resource and to
attract new investigators to the field of BPH.
匹兹堡大学跨学科规划中心(University of Pittsburgh Planning Center for Interdisciplinary
良性泌尿学研究(IR-BU)旨在研究“与前列腺相关的分子特征”,
啮齿动物模型中的炎症”。由于炎症在BPH中的重要性,一组研究人员
包括内分泌学,病理学,泌尿学和药理学在内的不同专业知识将共同努力,
确定炎症诱导的分子和细胞变化的相似性和不同性,和/或
在这个多学科的项目中,啮齿动物和人类之间的前列腺外。研究假设
前列腺炎症可以诱导与人类BPH相关的分子和细胞变化。这
在当前的资助期内,福尔马林诱导的低等级
炎症增强福尔马林注射大鼠前列腺模型中雄激素反应基因的表达
和我们之前的发现,雄激素反应基因的表达在人类BPH上皮细胞中升高,
细胞以福尔马林诱导的大鼠前列腺炎症为模型,我们建议确定
前列腺炎症对膀胱和传入功能的影响(具体目标1),
前列腺和尿液(具体目标2)和前列腺上皮-间质转化(具体目标3)。的
这项研究项目的成功将确定啮齿动物中的相关靶点和信号通路,
导致前列腺组织稳态改变,这是人类BPH的特征。
IR-BU建立了一个行政核心,其中包括一个执行委员会和一个内部
咨询委员会将通过项目审查提供强有力的行政支助,
合作和教育丰富。核心还将负责分配和监督
IR-BU资源。通过支持教育充实和研究项目,
核心将有助于既整合IR-BU到大学社区作为一种资源,
吸引新的研究人员进入BPH领域。
项目成果
期刊论文数量(0)
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专利数量(0)
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{{ truncateString('Zhou Wang', 18)}}的其他基金
Structural and functional analysis of a novel class of androgen receptor antagonists
一类新型雄激素受体拮抗剂的结构和功能分析
- 批准号:
10650956 - 财政年份:2023
- 资助金额:
$ 24.67万 - 项目类别:
Role of E-Cadherin Down-Regulation in Prostatic Inflammation and Lower Urinary Tract Dysfunction
E-钙粘蛋白下调在前列腺炎症和下尿路功能障碍中的作用
- 批准号:
10564514 - 财政年份:2023
- 资助金额:
$ 24.67万 - 项目类别:
Targeting androgen receptor nuclear localization in prostate cancer
前列腺癌中雄激素受体核定位的靶向
- 批准号:
10642683 - 财政年份:2022
- 资助金额:
$ 24.67万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9230541 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
10002325 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
The University of Pittsburgh O'Brien Urology Cooperative Research Center Program
匹兹堡大学奥布莱恩泌尿科合作研究中心项目
- 批准号:
10002341 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9764149 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
Luminal epithelial junctions, polarity, and permeability in BPH pathogenesis
BPH 发病机制中的管腔上皮连接、极性和渗透性
- 批准号:
10002344 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9357574 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
Luminal Epithelial Junctions, Polarity, and Permeability in BPH Pathogenesis
BPH 发病机制中的管腔上皮连接、极性和渗透性
- 批准号:
9323061 - 财政年份:2016
- 资助金额:
$ 24.67万 - 项目类别:
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