University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
基本信息
- 批准号:10002325
- 负责人:
- 金额:$ 120万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-22 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdvisory CommitteesAffectAnimalsBenign Prostatic HypertrophyBiometryBladderBudgetsClinicalCollectionCommunicationCommunitiesDataDiseaseDoctor of MedicineDoctor of PhilosophyDrug or chemical Tissue DistributionElderly manEndocrinologyEpithelialEpithelial CellsEpitheliumEstrogen Receptor betaFibrosisFundingGeneral PopulationGeneticGoalsGrantHeadHistopathologyHumanHuman ResourcesIndividualInflammationInterdisciplinary StudyJournalsLeadMedicalMedical centerMethodsMissionMolecularMolecular BiologyMonitorMorphologyNeurosciencesPathogenesisPathologyPatientsPermeabilityPharmaceutical PreparationsPharmacologyPhysiologyPilot ProjectsPreventiveProstateProstaticProstatic TissueResearchResearch PersonnelResearch Project GrantsResourcesRoleServicesSocietiesSpecimenStudentsSupervisionSymptomsTalentsTherapeuticTravelUnited States National Institutes of HealthUniversitiesUrologyUrotheliumanimal tissueclinical applicationclinically relevantcohesioncosthuman tissueinnovationlower urinary tract symptomsmeetingsmembermenmultidisciplinarynovelnovel strategiesoutreachpatient populationpreventprogramsprotective effectrecruitsuccesssymposiumsynergismtissue processingtissue resource
项目摘要
Abstract (Overall):
This new application from the University of Pittsburgh is for an O'Brien Urology Cooperative Research Center
Grant to elucidate "Molecular mechanisms of benign prostatic hyperplasia (BPH) and related lower urinary
tract symptoms (LUTS)". The Center investigators have expertise in an array of fields, including urology
endocrinology, molecular biology, pharmacology, physiology, neuroscience, genetics and pathology. Using
their various expertise, investigators developed multidisciplinary projects that contain basic mechanistic
components as well as the use of human clinical specimens to study BPH/LUTS. The following proposed
projects will address important factors involved in BPH/LUTS, with a focus on inflammation: Project 1: Afferent
and urothelial plasticity underlying bladder sensitization in prostatic inflammation (Naoki Yoshimura); Project 2:
Prostate luminal epithelial permeability and inflammation in BPH pathogenesis (Zhou Wang); Project 3: Impact
of Cox-2 on protective effects of estrogen receptor beta in prostate epithelial cells (Donald DeFranco).
The O'Brien Center has established an Administrative Core and a Tissue Resource and Morphology Core
(TRMC) to increase synergy and efficiency. The Administrative Core, which includes an Executive Committee,
an Internal Advisory Committee, and an External Advisory Committee, will provide strong administrative
support through project review, pilot project selection and monitoring, opportunity pool program, educational
enrichment, biostatistics analysis, clinical relevance review, and communication with general public. TRMC will
provide human tissue specimens, morphology support, and animal tissue processing and distribution.
Together, these Cores will help to both integrate the O'Brien Center into the University community by serving
as a resource and to attract new investigators to the field of BPH.
摘要(总体):
这份来自匹兹堡大学的新申请是为奥布莱恩泌尿学合作研究中心申请的
批准阐明“良性前列腺增生(BPH)及其相关下尿路疾病的分子机制”
上消化道症状(LUTS)该中心的研究人员在包括泌尿学在内的一系列领域都有专业知识
内分泌学、分子生物学、药理学、生理学、神经科学、遗传学和病理学。使用
研究人员利用各种专业知识开发了包含基本机械原理的多学科项目
成分以及使用人类临床标本来研究BPH/LUTS。以下拟议
项目将解决前列腺增生/下尿路症状涉及的重要因素,重点是炎症:项目1:传入
和前列腺炎症中膀胱致敏的尿道上皮可塑性(Naoki Yoshimura);项目2:
BPH发病机制中的前列腺腔上皮通透性和炎症(Zhou Wang);项目3:影响
考克斯-2对前列腺上皮细胞中雌激素受体β的保护作用(Donald DeFranco)。
奥布莱恩中心建立了一个行政核心和组织资源和形态核心
(TRMC)以提高协同作用和效率。行政核心包括一个执行委员会,
内部咨询委员会和外部咨询委员会将提供强有力的行政管理
通过项目审查、试点项目选择和监测、机会汇集方案、教育
丰富、生物统计学分析、临床相关性审查以及与公众的沟通。TRMC将
提供人体组织标本、形态学支持以及动物组织处理和分发。
总之,这些核心将有助于既整合奥布莱恩中心到大学社区服务
作为一种资源,并吸引新的研究人员到BPH领域。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib.
- DOI:
- 发表时间:2018-02
- 期刊:
- 影响因子:1.2
- 作者:Feng Li;Laura E. Pascal;Jianhua Zhou;Yibin Zhou;Ke Wang;A. Parwani;R. Dhir;P. Guo;D. He
- 通讯作者:Feng Li;Laura E. Pascal;Jianhua Zhou;Yibin Zhou;Ke Wang;A. Parwani;R. Dhir;P. Guo;D. He
Effects of dutasteride in a rat model of chemically induced prostatic inflammation-Potential role of estrogen receptor β.
- DOI:10.1002/pros.24071
- 发表时间:2020-12
- 期刊:
- 影响因子:0
- 作者:Mizoguchi S;Mori K;Shin T;Wang Z;DeFranco DB;Yoshimura N;Mimata H
- 通讯作者:Mimata H
Molecular correlates in urine for the obesity and prostatic inflammation of BPH/LUTS patients.
- DOI:10.1002/pros.23439
- 发表时间:2018-01
- 期刊:
- 影响因子:0
- 作者:Tyagi P;Motley SS;Koyama T;Kashyap M;Gingrich J;Yoshimura N;Fowke JH
- 通讯作者:Fowke JH
Effects of Estrogen Receptor β Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation.
- DOI:10.1002/pros.23320
- 发表时间:2017-05
- 期刊:
- 影响因子:0
- 作者:Mizoguchi S;Mori K;Wang Z;Liu T;Funahashi Y;Sato F;DeFranco DB;Yoshimura N;Mimata H
- 通讯作者:Mimata H
Therapeutic effects of nerve growth factor-targeting therapy on bladder overactivity in rats with prostatic inflammation.
- DOI:10.1002/pros.24227
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:Igarashi T;Tyagi P;Mizoguchi S;Saito T;Furuta A;Suzuki Y;Egawa S;Wang Z;Yoshimura N
- 通讯作者:Yoshimura N
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{{ truncateString('Zhou Wang', 18)}}的其他基金
Structural and functional analysis of a novel class of androgen receptor antagonists
一类新型雄激素受体拮抗剂的结构和功能分析
- 批准号:
10650956 - 财政年份:2023
- 资助金额:
$ 120万 - 项目类别:
Role of E-Cadherin Down-Regulation in Prostatic Inflammation and Lower Urinary Tract Dysfunction
E-钙粘蛋白下调在前列腺炎症和下尿路功能障碍中的作用
- 批准号:
10564514 - 财政年份:2023
- 资助金额:
$ 120万 - 项目类别:
Targeting androgen receptor nuclear localization in prostate cancer
前列腺癌中雄激素受体核定位的靶向
- 批准号:
10642683 - 财政年份:2022
- 资助金额:
$ 120万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9230541 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
The University of Pittsburgh O'Brien Urology Cooperative Research Center Program
匹兹堡大学奥布莱恩泌尿科合作研究中心项目
- 批准号:
10002341 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9764149 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
Luminal epithelial junctions, polarity, and permeability in BPH pathogenesis
BPH 发病机制中的管腔上皮连接、极性和渗透性
- 批准号:
10002344 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
University of Pittsburgh O'Brien Cooperative Research Center Program
匹兹堡大学奥布莱恩合作研究中心项目
- 批准号:
9357574 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
Luminal Epithelial Junctions, Polarity, and Permeability in BPH Pathogenesis
BPH 发病机制中的管腔上皮连接、极性和渗透性
- 批准号:
9323061 - 财政年份:2016
- 资助金额:
$ 120万 - 项目类别:
Molecular signatures associated with prostatic inflammation in rodent models.
啮齿动物模型中与前列腺炎症相关的分子特征。
- 批准号:
8566145 - 财政年份:2012
- 资助金额:
$ 120万 - 项目类别:
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