University of Pittsburgh O'Brien Cooperative Research Center Program

摘要(总体)： 这份来自匹兹堡大学的新申请是关于奥布莱恩泌尿外科合作研究中心的申请 GRANT阐明良性前列腺增生症(BPH)及相关下尿液的分子机制 肠道症状(LUTS)。该中心的调查人员在一系列领域拥有专业知识，包括泌尿学 内分泌学、分子生物学、药理学、生理学、神经科学、遗传学和病理学。vbl.使用 凭借他们的各种专业知识，调查人员开发出了包含基本机械原理的多学科项目 成分以及使用人类临床标本来研究BPH/LUTS。以下是建议的 项目将处理涉及BPH/LUTS的重要因素，重点是炎症：项目1：传入 前列腺炎中膀胱敏化的尿路上皮可塑性(Naoki Yoshimura)；项目2： 前列腺增生症发病机制中的前列腺腔上皮通透性和炎症(周旺)；项目3：影响 COX-2对雌激素受体β对前列腺上皮细胞的保护作用(唐纳德·德弗兰科) 奥布莱恩中心建立了一个管理核心和一个组织资源和形态核心 (TRMC)，以提高协同效应和效率。行政核心，包括一个执行委员会， 内部咨询委员会和外部咨询委员会将提供强有力的行政管理 通过项目审查、试点项目选择和监测、机会池计划、教育 丰富，生物统计分析，临床相关性审查，并与普通公众沟通。TRMC将 提供人体组织标本、形态支持，以及动物组织的加工和配送。 这些核心一起，将有助于将奥布莱恩中心融入大学社区，通过为 作为一种资源，并吸引新的研究人员到前列腺增生症领域。

Abstract (Overall): This new application from the University of Pittsburgh is for an O'Brien Urology Cooperative Research Center Grant to elucidate "Molecular mechanisms of benign prostatic hyperplasia (BPH) and related lower urinary tract symptoms (LUTS)". The Center investigators have expertise in an array of fields, including urology endocrinology, molecular biology, pharmacology, physiology, neuroscience, genetics and pathology. Using their various expertise, investigators developed multidisciplinary projects that contain basic mechanistic components as well as the use of human clinical specimens to study BPH/LUTS. The following proposed projects will address important factors involved in BPH/LUTS, with a focus on inflammation: Project 1: Afferent and urothelial plasticity underlying bladder sensitization in prostatic inflammation (Naoki Yoshimura); Project 2: Prostate luminal epithelial permeability and inflammation in BPH pathogenesis (Zhou Wang); Project 3: Impact of Cox-2 on protective effects of estrogen receptor beta in prostate epithelial cells (Donald DeFranco). The O'Brien Center has established an Administrative Core and a Tissue Resource and Morphology Core (TRMC) to increase synergy and efficiency. The Administrative Core, which includes an Executive Committee, an Internal Advisory Committee, and an External Advisory Committee, will provide strong administrative support through project review, pilot project selection and monitoring, opportunity pool program, educational enrichment, biostatistics analysis, clinical relevance review, and communication with general public. TRMC will provide human tissue specimens, morphology support, and animal tissue processing and distribution. Together, these Cores will help to both integrate the O'Brien Center into the University community by serving as a resource and to attract new investigators to the field of BPH.