University of Pittsburgh O'Brien Cooperative Research Center Program

摘要（总体）： 这份来自匹兹堡大学的新申请是为奥布莱恩泌尿学合作研究中心申请的 批准阐明“良性前列腺增生（BPH）及其相关下尿路疾病的分子机制” 上消化道症状（LUTS）该中心的研究人员在包括泌尿学在内的一系列领域都有专业知识 内分泌学、分子生物学、药理学、生理学、神经科学、遗传学和病理学。使用 他们的各种专业知识，研究人员开发了多学科项目，其中包含基本的机械 成分以及使用人类临床标本来研究BPH/LUTS。以下拟议 项目将解决涉及BPH/LUTS的重要因素，重点是炎症：项目1：传入 和前列腺炎症中膀胱致敏的尿道上皮可塑性（Naoki Yoshimura）;项目2： BPH发病机制中的前列腺腔上皮通透性和炎症（Zhou Wang）;项目3：影响 考克斯-2对前列腺上皮细胞中雌激素受体β的保护作用（Donald DeFranco）。 奥布莱恩中心建立了一个行政核心和组织资源和形态核心 （TRMC）以提高协同作用和效率。行政核心包括一个执行委员会， 一个内部咨询委员会和一个外部咨询委员会将提供强有力的行政管理， 通过项目审查、试点项目选择和监测、机会汇集方案、教育 丰富、生物统计学分析、临床相关性审查以及与公众的沟通。TRMC将 提供人体组织标本、形态学支持以及动物组织处理和分发。 总之，这些核心将有助于既整合奥布莱恩中心到大学社区服务 作为一种资源，并吸引新的研究人员到BPH领域。

Abstract (Overall): This new application from the University of Pittsburgh is for an O'Brien Urology Cooperative Research Center Grant to elucidate "Molecular mechanisms of benign prostatic hyperplasia (BPH) and related lower urinary tract symptoms (LUTS)". The Center investigators have expertise in an array of fields, including urology endocrinology, molecular biology, pharmacology, physiology, neuroscience, genetics and pathology. Using their various expertise, investigators developed multidisciplinary projects that contain basic mechanistic components as well as the use of human clinical specimens to study BPH/LUTS. The following proposed projects will address important factors involved in BPH/LUTS, with a focus on inflammation: Project 1: Afferent and urothelial plasticity underlying bladder sensitization in prostatic inflammation (Naoki Yoshimura); Project 2: Prostate luminal epithelial permeability and inflammation in BPH pathogenesis (Zhou Wang); Project 3: Impact of Cox-2 on protective effects of estrogen receptor beta in prostate epithelial cells (Donald DeFranco). The O'Brien Center has established an Administrative Core and a Tissue Resource and Morphology Core (TRMC) to increase synergy and efficiency. The Administrative Core, which includes an Executive Committee, an Internal Advisory Committee, and an External Advisory Committee, will provide strong administrative support through project review, pilot project selection and monitoring, opportunity pool program, educational enrichment, biostatistics analysis, clinical relevance review, and communication with general public. TRMC will provide human tissue specimens, morphology support, and animal tissue processing and distribution. Together, these Cores will help to both integrate the O'Brien Center into the University community by serving as a resource and to attract new investigators to the field of BPH.