Parents and Children Together Preventing Diabetes (PACT PD)

父母和孩子一起预防糖尿病 (PACT PD)

• 批准号: 8368921
• 负责人: Bettina M. Beech
• 金额: $ 23.25万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8368921
• 关键词: 10 year old; Accounting; Address; Adult; African American; American; Behavioral Genetics; Body Weight Changes; Body Weight decreased; Caucasians; Caucasoid Race; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Chronic Disease; Clinical Trials; Communities; Community Health; Cost Analysis; Data; Daughter; Diabetes Mellitus; Diabetes prevention; Diagnosis; Diet; Disease Clusterings; Effectiveness; Family; Family health status; Future; Health; Individual; Intervention; Intervention Studies; Life; Life Style; Minority; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Parents; Pilot Projects; Positioning Attribute; Prediabetes syndrome; Prevention; Preventive Intervention; Public Health; Randomized; Recruitment Activity; Risk; Site; Techniques; Testing; Training; Translating; Translations; United States; Work; base; boys; cost; design; diabetes prevention program; experience; fitness; girls; health economics; improved; lifestyle intervention; motivational enhancement therapy; multidisciplinary; prevent; programs; randomized trial; weight gain prevention

DESCRIPTION (provided by applicant): Type 2 diabetes (T2DM) is a disease that clusters in families due to genetic, behavioral, and cultural risk factors.1 T2DM accounts for at least 90% of diabetes in the United States and an additional 7.9 million individuals have prediabetes (American Diabetes Association, 2011). African Americans are disproportionately represented among those diagnosed with T2DM and prediabetes (CDC).2~3 Effective, culturally-relevant, family-based diabetes prevention interventions are critically needed for African Americans. The Diabetes Prevention Program (DPP) and other clinical trials over the past decade have demonstrated that T2DM can be successfully prevented or delayed with intensive lifestyle interventions addressing diet and physical activity.4-6 Two recent effective community-based translations of the DPP have achieved similar outcomes with less intensive interventions delivered by community-health workers7 and trained YMCA lifestyle coaches.8 Both of these studies focused solely on individual adults~ little is known about how best to translate DPP from a family perspective. Power to Prevent is an existing CDC diabetes prevention program, based on DPP, and designed specifically for use with African American families at risk for T2DM. To our knowledge, this program has not yet been evaluated in a randomized trial with African American families. We propose to leverage the evidence on the effectiveness of YMCA lifestyle coaches in delivering diabetes prevention interventions and train YMCA fitness staff to serve as "family health coaches" to implement the Power to Prevent program with overweight/obese African American parents and their overweight/obese 8-10 year old children. We propose the Parents and Children Together Preventing Diabetes (PACT-PD) study, a two-condition randomized family-based pilot study translation of DPP. Our group is ideally positioned to implement and evaluate the family-based diabetes prevention intervention with African American families having extensive experience in conducting community- and family-based interventions, particularly with African Americans. If our study is successful, our translated intervention could be disseminated rapidly to thousands of YMCAs in the United States, thereby making a substantial impact on the public health burden of obesity, diabetes, and other lifestyle related chronic diseases. PUBLIC HEALTH RELEVANCE: Narrative African American adults and children experience higher rates of obesity and T2DM, compared to their Caucasian counterparts.21 Alarmingly, about 50% of AA U.S. children are expected to develop T2DM in their lifetime.22 We propose to conduct a randomized pilot study to evaluate the early efficacy of a diabetes prevention intervention specifically designed for African American families.

描述（由申请人提供）：2型糖尿病（T2DM）是一种由于遗传、行为和文化风险因素而聚集在家族中的疾病在美国，2型糖尿病至少占糖尿病患者的90%，另外还有790万人患有前驱糖尿病（美国糖尿病协会，2011年）。非裔美国人在诊断为2型糖尿病和前驱糖尿病（CDC）的人群中所占比例过高。2~3非洲裔美国人迫切需要有效的、与文化相关的、基于家庭的糖尿病预防干预措施。糖尿病预防计划（DPP）和过去十年的其他临床试验表明，通过强化饮食和体育活动的生活方式干预，可以成功预防或延迟2型糖尿病。4-6最近两个有效的社区翻译的DPP通过社区卫生工作者和YMCA训练有素的生活方式教练提供的不那么密集的干预取得了类似的结果这两项研究都只关注成年人个体，对于如何最好地从家庭角度解读DPP知之甚少。Power to prevention是CDC现有的糖尿病预防项目，以DPP为基础，专为有2型糖尿病风险的非裔美国家庭设计。据我们所知，该项目尚未在非裔美国家庭的随机试验中进行评估。我们建议利用YMCA生活方式教练在提供糖尿病预防干预措施方面的有效性的证据，并培训YMCA健身人员作为“家庭健康教练”，对超重/肥胖的非裔美国父母及其8-10岁超重/肥胖的孩子实施预防的力量计划。我们提出父母和孩子共同预防糖尿病（PACT-PD）研究，这是一项基于DPP的双条件随机家庭试点研究。我们的小组在实施和评估以家庭为基础的糖尿病预防干预方面处于理想的位置，非洲裔美国家庭在实施以社区和家庭为基础的干预方面具有丰富的经验，特别是对非洲裔美国人。如果我们的研究成功，我们的翻译干预可以迅速传播到美国成千上万的基督教青年会，从而对肥胖、糖尿病和其他与生活方式相关的慢性疾病的公共卫生负担产生重大影响。