PROJECT 1: Community Health Assessment of Risks associated with the Macondo Spill

德克萨斯大学加尔维斯顿分校（UTMB）在深水地平线爆炸后不久就参与了石油泄漏的应对工作。与社区团体就环境健康影响进行的多次讨论表明，主要关注的问题是缺乏对石油中产岩多环烃（PAHs）安全性的了解，由于使用分散剂而对其进行处置，以及对食物网的长期影响和对人类健康的影响。由于许多家庭不仅以海湾海鲜为生，而且还依靠其收获获得经济支持，因此人们的担忧有所增加。因此，本提案旨在了解石油污染对墨西哥湾造成的长期健康影响，重点是海湾鱼类和贝类以及食用它们对人类的潜在影响。项目1采用基于社区的参与性研究（CBPR），在每个阶段都让社区积极参与。鉴于许多沿海社区也遭受了一系列自然灾害，我们将在个人和社区两级评估对人类健康的影响。项目1包括：来自洛杉矶和MS的社区组织，UTMB，宾夕法尼亚大学，加尔维斯顿的德克萨斯农工大学，洛杉矶州立大学，以及

The University of Texas Medical Branch at Galveston (UTMB) has been involved in response to the oil spill since shortly after the explosion of the Deepwater Horizon. Multiple discussions with community groups related to environmental health impacts have revealed primary concerns over lack of knowledge regarding the safety of petrogenic polycyclic hydrocarbons (PAHs) in the oil, its disposition due to use of dispersants, and long-term effects on the food web and human health effects. Concerns are increased since many families not only subsist on Gulf seafood but also rely on its harvest for financial support. This proposal thus seeks to understand the long-term health effects arising from contamination of the (3ulf by oil, with emphasis on Gulf finfish and shellfish and potential effects in humans consuming them. Project 1 utilizes a Community-Based Participatory Research (CBPR), which actively involves the community in each phase. We will assess effects on human health at both individual and community levels, given that many Coastal communities have also suffered from a sequence of natural disasters. Project 1 includes: community organizations from LA and MS, UTMB, the University of Pennsylvania, Texas A&M University at Galveston, LA State University, and the University of AZ. Specific aims include: 1) establishing the consortium between Gulf fishing communities and academic scientists; 2) carrying out a comprehensive health assessment of exposed Gulf-fishing community members residing in LA and MS to include measures of parent petrogenic PAH in biospecimens and health effects, to be analyzed in Project 2; 3) measuring exposure and response biomarkers of petrogenic PAH, biomarkers of health effects including smoke exposure and psychosocial stress, and intermediate cancer biomarkers in the Project 1 cohort to be analyzed in Projects 3 and 4; 4) assessing the relationship of consumption of Gulf seafood and biomarkers of exposure, effect, and oxidative stress in the Gulf Coast population, 5) assessing the household and community economics of seafood; 6) investigating the inherent/traditional community resilience in affected communities and 7) evaluating the success of processes and outcomes in meeting identified needs.