PROJECT 1: Community Health Assessment of Risks associated with the Macondo Spill

项目 1：马孔多泄漏事件相关风险的社区健康评估

• 批准号: 8469041
• 负责人: Sharon A Croisant
• 金额: $ 47.74万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8469041
• 关键词: Accounting; Address; Affect; Anthropology; Arizona; Biological Markers; Communities; Community Health; Community Outreach; Consumption; Crabs; DNA Adducts; Demographic Factors; Development; Disease; Economics; Education and Outreach; Ensure; Environmental Health; Event; Explosion; Family; Feedback; Financial Support; Fishes; Food Webs; Future; Gases; Glucocorticoids; Goals; Harvest; Health; Health Alliance; Household; Human; Hurricane; Individual; Industry; Institution; Knowledge; Long-Term Effects; Longitudinal Studies; Louisiana; Malignant Neoplasms; Marines; Measures; Medical; Mississippi; National Institute of Environmental Health Sciences; Natural Disasters; Nature; Nicotine; Occupations; Oils; Outcome; Oxidative Stress; Oysters; Parents; Pennsylvania; Phase; Polycyclic Hydrocarbons; Population; Process; Property; Psyche structure; Psychosocial Stress; Research; Research Personnel; Risk; Risk Assessment; Role; Safety; Sales; Sampling; Science; Scientist; Seafood; Sentinel; Shellfish; Shrimp; Smoke; Stress; Texas; Toxic effect; Translating; Uncertainty; Universities; Work; base; cohort; community based participatory research; community organizations; design; empowered; environmental toxicology; gulf coast; high throughput screening; lifestyle factors; meetings; member; research facility; resilience; response; social; sound; stressor; success

The University of Texas Medical Branch at Galveston (UTMB) has been involved in response to the oil spill since shortly after the explosion of the Deepwater Horizon. Multiple discussions with community groups related to environmental health impacts have revealed primary concerns over lack of knowledge regarding the safety of petrogenic polycyclic hydrocarbons (PAHs) in the oil, its disposition due to use of dispersants, and long-term effects on the food web and human health effects. Concerns are increased since many families not only subsist on Gulf seafood but also rely on its harvest for financial support. This proposal thus seeks to understand the long-term health effects arising from contamination of the (3ulf by oil, with emphasis on Gulf finfish and shellfish and potential effects in humans consuming them. Project 1 utilizes a Community-Based Participatory Research (CBPR), which actively involves the community in each phase. We will assess effects on human health at both individual and community levels, given that many Coastal communities have also suffered from a sequence of natural disasters. Project 1 includes: community organizations from LA and MS, UTMB, the University of Pennsylvania, Texas A&M University at Galveston, LA State University, and the University of AZ. Specific aims include: 1) establishing the consortium between Gulf fishing communities and academic scientists; 2) carrying out a comprehensive health assessment of exposed Gulf-fishing community members residing in LA and MS to include measures of parent petrogenic PAH in biospecimens and health effects, to be analyzed in Project 2; 3) measuring exposure and response biomarkers of petrogenic PAH, biomarkers of health effects including smoke exposure and psychosocial stress, and intermediate cancer biomarkers in the Project 1 cohort to be analyzed in Projects 3 and 4; 4) assessing the relationship of consumption of Gulf seafood and biomarkers of exposure, effect, and oxidative stress in the Gulf Coast population, 5) assessing the household and community economics of seafood; 6) investigating the inherent/traditional community resilience in affected communities and 7) evaluating the success of processes and outcomes in meeting identified needs.

自从深水地平线爆炸后不久以来，加尔维斯顿大学（UTMB）的德克萨斯大学医学分支已经参与了漏油事件。与与环境健康影响有关的社区群体的多次讨论表明，关于石油中石油多环烃（PAH）的安全性缺乏知识的主要关注点，由于使用分散剂而引起的处置以及对食物网和人类健康影响的长期影响。由于许多家庭不仅依靠海湾海鲜，而且还依靠其收获来获得财政支持，因此担心会增加。因此，该提案试图理解（石油3英uf的污染，重点是墨西哥湾鳍鱼和贝类以及对人类食用它们的潜在影响的重点。项目1利用基于社区的参与性研究（CBPR）（CBPR），该研究在每个阶段积极涉及每个阶段的社区。我们将在许多层面上对人类的健康群体进行影响，包括一位临界范围。来自洛杉矶和MS的社区组织，UTMB，宾夕法尼亚大学，得克萨斯州A＆M大学，加尔维斯顿，洛杉矶州立大学， 亚利桑那大学。具体目的包括：1）建立海湾捕鱼社区与学术科学家之间的财团； 2）对居住在洛杉矶和MS中的裸露的海湾捕捞社区成员进行全面的健康评估，包括在生物测量和健康效应中的父母质PAH的措施，并在项目2中进行分析； 3）测量岩性PAH的暴露和反应生物标志物，健康影响的生物标志物，包括烟雾暴露和社会心理压力，以及项目1同类中的中间癌症生物标志物，将在项目3和4中进行分析； 4）评估海湾海鲜的消费与墨西哥湾沿岸人口的暴露，效果和氧化应激的生物标志物的关系，5）评估海鲜的家庭和社区经济学； 6）调查受影响社区的固有/传统社区韧性，7）评估过程和结果在满足确定需求方面的成功。