A Twin Study of Negative Valence Emotional Constructs

负价情感结构的双胞胎研究

• 批准号: 8366120
• 负责人: JOHN M HETTEMA
• 金额: $ 47.73万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366120
• 关键词: Address; Adolescence; Adolescent; Affect; Affective; Age; Anxiety; Anxiety Disorders; Basic Science; Behavior; Brain; Child; Childhood; Clinical; Cognitive; Data; Depressive disorder; Development; Diagnostic; Diagnostic and Statistical Manual; Dimensions; Disease; Drug Formulations; Emotional; Environment; Epidemiology; Etiology; Genes; Genetic; Genetic Risk; High Prevalence; Lead; Measures; Mental Depression; Methodology; Neurobiology; Outcome; Phenotype; Prevention; Process; Psychopathology; Psychophysiology; Public Health; Research; Risk; Risk Factors; Role; Sampling; Source; Specificity; Strategic Planning; Structure; Symptoms; Syndrome; System; Twin Multiple Birth; Twin Studies; base; design; disease classification; emotional stimulus; insight; instrument; novel; novel strategies; psychologic; response

DESCRIPTION (provided by applicant): Internalizing disorders, consisting of syndromes of anxiety and depression, represent common, debilitating conditions, the etiology of which is not well understood. Neuroscientists have developed dimensional assessment instruments and psychological tasks that probe negative valence systems as alternative phenotypes to clinical symptoms. Such alternative phenotypes are under consideration for use in the NIMH's Research Domain Criteria (RDoC) project. However, little is currently known regarding their genetic basis and how that relates to internalizing risk factors. This study will extend and deepen our understanding of the relationships between such alternative phenotypes and early manifestations of ID symptomatology. The approach will be to administer an informative suite of dimensional measures and experimental tasks to 500 pre-adolescent twin pairs from a large epidemiological sample. These subjects will also be assessed for current and lifetime internalizing psychopathology and a broad array of childhood risk/ protective factors. The expected outcome is to provide novel insights into the mechanisms by which genes and environment confer risk to internalizing disorders via these more basic phenotypes that putatively reflect underlying affective processing. PUBLIC HEALTH RELEVANCE: The high prevalence of anxiety and depressive disorders makes them a significant public health burden in the US. They often begin in childhood, but little is known about the mechanisms by which they affect some children but not others. This study, performed in pediatric twin pairs to understand genetic mechanisms, uses novel approaches to measure ways that children at risk for these conditions respond to negative emotional stimuli. Insights gained from this study can lead to significant advances in prevention and treatment for these conditions.

描述（由申请人提供）：内化障碍，由焦虑和抑郁症状组成，代表常见的，使人衰弱的状况，其病因尚不清楚。神经科学家已经开发了维度评估工具和心理任务，探索负价系统作为临床症状的替代表型。NIMH的研究领域标准（RDoC）项目正在考虑使用这些替代表型。然而，目前对其遗传基础及其与内化风险因素的关系知之甚少。这项研究将扩展和加深我们对这种替代表型与ID症状学早期表现之间关系的理解。该方法将对来自大型流行病学样本的500对青春期前双胞胎进行一套信息丰富的维度测量和实验任务。这些受试者还将被评估当前和终生的内化精神病理学和一系列广泛的儿童风险/保护因素。预期的结果是提供新的见解的机制，基因和环境赋予风险内化障碍通过这些更基本的表型，推定反映潜在的情感处理。