Predoctoral Training Program in Molecular Pharmacology

描述（由申请人提供）：梅奥研究生院分子药理学和实验治疗学（MPET）博士培训计划的主要目标是培养能够指导学术界，工业界或其他环境中杰出研究项目的独立研究人员。该学院由28名资金充足的独立研究人员组成，他们专注于一系列研究领域，包括从疾病的基本分子和遗传方面到药物发现和心血管疾病和恶性疾病的新疗法的开发。该学院提供的培训领域包括计算化学、药物作用和耐药性的分子机制、代谢组学、新型治疗策略、成瘾遗传学、临床前和临床药理学以及与药物反应相关的基因的药物基因组学。目前在读博士研究生26人。严格的教学课程包括一系列核心课程，确保学生在生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学方面有扎实的基础知识，以及一系列以辅导为基础的课程，为学生提供分子药理学方面的高级培训。在前两年的学习中，学生至少要完成3个实验室轮转，并选择一个实验室进行论文研究。他们在第二年结束时参加全面的书面和口头资格考试。在制定书面论文提案，描述论文研究中要追求的问题和方法后，论文委员会在第一次委员会会议上审查拟议的研究。学生目前正在进行的研究项目的更新，每年MPET教师和学生。要求学生及时发表已完成的作品，并鼓励他们参加全国性的会议来展示他们的作品。完成博士课程的平均时间为5.2年。从三年级及以后开始，学生每年至少两次与论文委员会会面，并接受指导，以确定优秀的博士后培训机会，作为他们职业发展的下一步。MPET博士培训项目的毕业生有出色的业绩记录。他们继续获得博士后奖学金，其中许多人现在担任学术界和工业界的首席研究员。我们为下一个资助期申请4个职位。

DESCRIPTION (provided by applicant): The primary goal of the Ph.D. Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Graduate School is the development of independent investigators capable of directing outstanding research Programs in academia, industry or other settings. The faculty is comprised of 28 well- funded, independent investigators, who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for cardiovascular and malignant diseases. The faculty provides training opportunities in areas that include computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Twenty-six predoctoral students are currently enrolled in the MPET Ph.D. training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures a strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology and a series of tutorial-based courses to provide students with advanced training in molecular pharmacology. During their first two years of study, students complete at least 3 laboratory rotations and select a laboratory for their thesis research. They sit for comprehensive written and oral qualifying examinations at the end of year two. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the thesis committee reviews the proposed research at the first committee meeting. Student's present work-in-progress updates on their research projects to MPET faculty and students each year. Students are required to publish completed work in a timely manner and encouraged to attend national meetings to present their work. The average time to completion of the Ph.D. Program is 5.2 years. Starting in Year 3 and beyond, students meet with their thesis committees at least twice per year and are mentored to identify outstanding postdoctoral training opportunities as the next step in their career development. Graduates of the MPET Ph.D. training program have outstanding track records. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 4 positions for the next funding period.