Predoctoral Training Program in Molecular Pharmacology

描述（由申请人提供）：博士的主要目标。马约研究生院的分子药理学和实验治疗学（MPET）培训计划是能够指导学术界，工业界或其他环境中杰出研究计划的独立调查人员的发展。该学院由28名资金充足的独立研究人员组成，他们专注于一系列研究领域，包括从疾病的基本分子和遗传方面的研究，通过药物发现和开发心血管和恶性疾病的新疗法。该学院提供包括计算化学，药物作用和抗性的分子机制，代谢组学，新型治疗策略，成瘾遗传学，临床前和临床药理学以及与药物反应相关的基因的药物基因组学等领域的培训机会。目前有26名博士生在MPET博士就读。培训计划。严格的教学课程包括一系列核心课程，确保生物化学，分子生物学，遗传学，统计学，细胞生物学和药理学方面的基础知识，以及一系列基于辅导的课程，为学生提供分子药理学的高级培训。在前两年的学习中，学生至少完成3次实验室轮换，并选择一个实验室进行论文研究。他们在第二年年底参加综合笔试和口试。在编写了一份书面论文提案，描述了论文研究中要追求的问题和方法后，论文委员会在第一次委员会会议上审查了拟议的研究。学生每年向MPET教职员工和学生提供其研究项目的当前正在进行的工作更新。要求学生及时发表完成的工作，并鼓励参加全国会议，介绍他们的工作。完成博士学位的平均时间计划是5.2年。从3年级及以后开始，学生每年至少与论文委员会会面两次，并接受指导，以确定优秀的博士后培训机会作为他们职业发展的下一步。MPET博士毕业生培训计划有着出色的跟踪记录。他们继续博士后奖学金，许多人现在担任学术界和工业界的主要研究人员。我们要求在下一个供资期设立4个职位。

DESCRIPTION (provided by applicant): The primary goal of the Ph.D. Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Graduate School is the development of independent investigators capable of directing outstanding research Programs in academia, industry or other settings. The faculty is comprised of 28 well- funded, independent investigators, who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for cardiovascular and malignant diseases. The faculty provides training opportunities in areas that include computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Twenty-six predoctoral students are currently enrolled in the MPET Ph.D. training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures a strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology and a series of tutorial-based courses to provide students with advanced training in molecular pharmacology. During their first two years of study, students complete at least 3 laboratory rotations and select a laboratory for their thesis research. They sit for comprehensive written and oral qualifying examinations at the end of year two. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the thesis committee reviews the proposed research at the first committee meeting. Student's present work-in-progress updates on their research projects to MPET faculty and students each year. Students are required to publish completed work in a timely manner and encouraged to attend national meetings to present their work. The average time to completion of the Ph.D. Program is 5.2 years. Starting in Year 3 and beyond, students meet with their thesis committees at least twice per year and are mentored to identify outstanding postdoctoral training opportunities as the next step in their career development. Graduates of the MPET Ph.D. training program have outstanding track records. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 4 positions for the next funding period.