Predoctoral Training Program in Molecular Pharmacology

描述(由申请人提供)：梅奥研究生院分子药理学和实验治疗(MPET)博士培训计划的主要目标是培养能够指导学术界、工业界或其他领域杰出研究计划的独立研究人员。该学院由28名资金充足的独立研究人员组成，他们专注于一系列研究领域，包括从疾病的基本分子和遗传方面到药物发现和心血管疾病和恶性疾病新疗法的开发。该学院在计算化学、药物作用和耐药性的分子机制、代谢组学、新的治疗策略、成瘾遗传学、临床前和临床药理学以及与药物反应相关的基因的药物基因组学等领域提供培训机会。目前有26名博士前学生参加了MPET博士培训计划。严格的教学课程包括一系列核心课程，以确保在生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学方面具有扎实的基础知识，以及一系列以辅导为基础的课程，为学生提供分子药理学方面的高级培训。在头两年的学习中，学生至少要完成3次实验室轮换，并选择一个实验室进行论文研究。他们在第二年末参加综合的笔试和口试。在制定了一份书面的论文提案后，论文委员会在第一次委员会会议上对拟议的研究进行了审查。学生目前正在进行的研究项目的最新进展，每年向教师和学生。要求学生及时发表完成的作品，并鼓励他们参加全国性的会议来展示他们的作品。完成博士课程的平均时间为5.2年。从第三年开始，学生每年至少与论文委员会会面两次，并指导他们寻找优秀的博士后培训机会，作为他们职业发展的下一步。MPET博士培训项目的毕业生有着出色的成绩。他们继续担任博士后研究员，其中许多人现在是学术界和工业界的首席研究员。我们要求4个职位，为下一个资金时期。

DESCRIPTION (provided by applicant): The primary goal of the Ph.D. Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Graduate School is the development of independent investigators capable of directing outstanding research Programs in academia, industry or other settings. The faculty is comprised of 28 well- funded, independent investigators, who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for cardiovascular and malignant diseases. The faculty provides training opportunities in areas that include computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Twenty-six predoctoral students are currently enrolled in the MPET Ph.D. training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures a strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology and a series of tutorial-based courses to provide students with advanced training in molecular pharmacology. During their first two years of study, students complete at least 3 laboratory rotations and select a laboratory for their thesis research. They sit for comprehensive written and oral qualifying examinations at the end of year two. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the thesis committee reviews the proposed research at the first committee meeting. Student's present work-in-progress updates on their research projects to MPET faculty and students each year. Students are required to publish completed work in a timely manner and encouraged to attend national meetings to present their work. The average time to completion of the Ph.D. Program is 5.2 years. Starting in Year 3 and beyond, students meet with their thesis committees at least twice per year and are mentored to identify outstanding postdoctoral training opportunities as the next step in their career development. Graduates of the MPET Ph.D. training program have outstanding track records. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 4 positions for the next funding period.