COBRE Center for Molecular and Tumor Virology

作为生命系统的天然探针，病毒提供了一些对基本生物过程的最基本的见解：DMA复制，转录和翻译，细胞信号传导途径，癌基因和肿瘤抑制因子，以及宿主免疫防御。它们作为生物战和新发传染病病原体的重要性，以及它们在分子医学时代作为新疗法的潜力，推动了2003年在路易斯安那州立大学什里夫波特健康科学中心建立分子和肿瘤病毒学中心（CMTV）。经过四年的COBRE支持，我们为在一个没有强大研究传统的机构建立世界级病毒学中心奠定了基础。CMTV是通过积极的教师招聘，对年轻研究人员的勤奋指导，广泛的合作来创建可持续的研究基础设施，并将COBRE目标与新制定的大学长期研究发展战略计划相结合而建立起来的。随着CMTV现在提供了一种力量元素，可以用来增强整个校园的整体研究任务，我们建议通过以下方式扩大所要求的COBRE支持的影响：1)扩展CMTV，超越原来的单一部门基础，创建跨学科的协同科学合作，促进研究成果的临床应用，并涉及北路易斯安那州的三所大学，整合COBRE和INBRE项目；2)指导以前由COBRE资助的研究人员的发展，并支持五位新的项目负责人，他们的多学科研究通过解决病毒发病机制的分子基础的共同主题相互关联；3)通过创建与现有共享服务完全集成和/或互补的COBRE核心来增强研究基础设施。与实质性的大学承诺一起，包括生物医学研究的振兴使命，CMTV发展的最后阶段将创建一个中心，响应COBRE倡议和NIH路线图的总体目标，并植根于优秀的基础科学研究，强调从实验室到床边再到背后的假设驱动研究的应用。

As natural probes of living systems, viruses have provided some of the most fundamental insights into basic biological processes: DMA replication, transcription and translation, cell signaling pathways, oncogenes and tumor suppressors, and host immune defense. Their importance as agents of biowarfare and emerging infectious diseases, together with their potential for use as novel therapeutics in an age of molecular medicine, provided the impetus for the creation of the Center of Molecular and Tumor Virology (CMTV) at Louisiana State University Health Sciences Center- Shreveport in 2003. After four years of COBRE support we have laid the foundation for a world-class virology center at an institution without a strong research tradition. The CMTV was built by aggressive faculty recruitment, diligent mentoring of young investigators, extensive partnering to create a sustainable research infrastructure, and melding COBRE goals with a newly formulated University strategic plan for long-range research development. With the CMTV now providing an element of strength that can be used to enhance the overall research mission campus-wide, we propose to broaden the impact of the requested COBRE support by 1) expansion of the CMTV beyond its original single departmental base to create synergistic scientific collaborations that are interdisciplinary, promote clinical applications of research findings, and involve three universities in North Louisiana and integrate COBRE and INBRE programs; 2) mentored development of investigators previously funded by the COBRE, together with backing for five new Project Leaders whose multidisciplinary research is interconnected by a shared theme addressing the molecular basis for viral pathogenesis; 3) enhancement of research infrastructure by the creation of COBRE Cores that fully integrate with and/or complement existing shared services. Together with the substantive University commitment to a revitalized mission that embraces biomedical research, this final phase of CMTV development will create a Center that is responsive to overall goals of the COBRE initiative and NIH Roadmap and is rooted in excellent basic science investigation with a translational emphasis that favors application of hypothesis-driven investigation from bench to bedside and back.