Macromolecular Diffraction Resource: MacCHESS

MacCHESS是一个用于大分子晶体学的同步辐射研究资源， 通过创新技术研究和开发推进结构生物学前沿的目标 和用户支持。MacCHESS利用国家科学基金会在康奈尔高中的投资 能源同步加速器源（CHESS），它维持同步辐射实验室， 基本粒子物理实验室（LEPP），负责操作储存环。MacCHESS技术 发展是由涉及广泛的核心和合作研究项目驱动的， 大分子除了进行技术研发和核心研究，MacCHESS还提供 高分子晶体学的专业仪器和用户培训和支持人员。 MacCHESS已成为世界上最具生产力的高分子材料生产设施之一。 晶体学与近400篇论文发表在过去四年中，由于MacCHESS 相关技术研发、核心及协作研究与服务。超过23个 这些论文发表在知名度很高的《科学》、《自然》和《细胞》杂志上。三盘棋 A-1、F-1和F-2站用于大分子晶体学实验。未来五 未来10年，MacCHESS的技术研发将专注于（1）微晶学，（2）压力冷却及相关技术。 程序，（3）SAXS和包络定相，（4）自动化和高通量，以及（5）用于 长波长晶体学这些技术研发工作中的每一项都是由具有挑战性的问题驱动的 由研究分子和大分子复合物的原子结构的合作研究人员提出， 目前医学和生物学的兴趣，包括膜蛋白，信号蛋白复合物，核酸 酸/蛋白质复合物、蛋白质药物相互作用和病毒。技术发展， MacCHESS的研究成果免费提供给科学界，并通过会议传播， 研讨会、出版物、网络发行以及与其他同步加速器来源的合作。

MacCHESS, a synchrotron radiation research resource for macromolecular crystallography, has the overall goal of advancing the frontiers of structural biology through innovative technical research and development and user support. MacCHESS leverages the National Science Foundation investments in the Cornell High Energy Synchrotron Source (CHESS), which maintains the synchrotron radiation laboratory, and the Laboratory for Elementary Particle Physics (LEPP), which operates the storage ring. MacCHESS technical developments are driven by both core and collaborative research projects involving a broad range of macromolecules. In addition to performing technical R&D and core research, MacCHESS provides specialized instrumentation for macromolecular crystallography and a staff for user training and support. MacCHESS has established itself as one of the most productive facilities in the world for macromolecular crystallography with almost 400 papers published during the past four years as a result of MacCHESS related technical research and development, core and collaborative research and service. More than 23 of these papers were published in the high visibility journals, Science, Nature, and Cell. Three CHESS stations, A-1, F-1 and F-2, are used for macromolecular crystallography experiments. During the next five years, MacCHESS technical R&D will focus on (1) microcrystallography, (2) pressure crycooling and related procedures, (3) SAXS and envelope phasing, (4) automation and high-throughput, and (5) a new station for long wavelength crystallography. Each of these technical R&D efforts is driven by the challenging problems presented by collaborating investigators who study the atomic structure of molecules and complexes of great current interest to medicine and biology, including membrane proteins, signaling protein complexes, nucleic acid/protein complexes, protein drug interactions and viruses. Technical developments resulting from MacCHESS research are freely available to the scientific community and disseminated through meetings, workshops, publications, web distributions and collaborations with other synchrotron sources.