Enabling technologies for ultra-high sensitivity PET scanners (PQ13)

超高灵敏度 PET 扫描仪的支持技术 (PQ13)

• 批准号: 8384670
• 负责人: RAMSEY D. BADAWI
• 金额: $ 57.4万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8384670
• 关键词: Accounting; Address; Architecture; Clinical; Communities; Computer software; Country; Data Set; Development; Devices; Dose; Drug Delivery Systems; Drug Kinetics; Educational workshop; Electronics; Ensure; Facility Accesses; Funding; Goals; Health; Housing; Image; Kinetics; Laboratories; Length; Lesion; Medical; Medical Research; Memory; Methods; Metric; Modeling; Monte Carlo Method; Noise; Performance; Physiological; Positron-Emission Tomography; Public Domains; Research; Research Institute; Research Personnel; Resolution; Signal Transduction; Simulate; Solid; Specific qualifier value; System; Techniques; Technology; Testing; Time; To specify; Variant; Work; base; cost; data acquisition; density; design; detector; drug development; image reconstruction; improved; instrumentation; longitudinal positron emission tomography; meetings; meter; novel strategies; open source; radiotracer; reconstruction; simulation; usability

DESCRIPTION (provided by applicant): The overall goal of this application is to develop enabling technologies for the construction of a very large axial field of view PET scanner with effective performance 100-fold greater than existing systems. Specific Aims: We will (1) use simulations to specify spatial resolution and time of flight capabilities that will achieve 100-fol increase in the square of the pre-whitening signal to noise ratio; (2) Build a dialog with clinical researchers to specify requirements and trade-offs for a useful complete device; (3) Design, fabricate and characterize detectors that meet the performance specified in Aim 1; (4) Develop new factorized, parallelized reconstruction methods that can handle the datasets from the scanner in an efficient and scalable manner; (5) Create accurate simulations of electronics systems capable of supporting the ultra-sensitive PET scanner and model the final design options (6) complete planning and costing for the fabrication of the complete device. Methods: Monte-Carlo simulations will be used to specify scanner requirements. Detectors based on 2 variants of existing scintillator-based approaches will be fabricated and tested. A workshop will be held at which clinical researchers and investigators can discuss design issues relating to the project will be held. Electronics configurations based on the open source OpenPET suite and on designs provided by Toshiba Medical will be accurately simulated in software and their performance in conjunction with the detectors built in Aim 2 tested. The investigators will then finalize a design for the scanner, cost it out and apply for funds to complete the project. In the long term, the scanner will be housed in a National Ultra-sensitive PET Facility and access given to academic and industrial researchers from across the country. Health-relatedness: This application will lay the ground-work for the fabrication of an ultra-high sensitivity PET scanner, which can be used to detect much smaller lesions than is currently possible. In addition it can be used to perform kinetic modeling of physiological parameters across the entire body, which can be used to better characterize pathological conditions. It can be used to perform low-dose longitudinal PET studies. It can also be used to determine drug kinetics and targeting early in the drug development pipeline. PUBLIC HEALTH RELEVANCE: This application will lay the ground-work for the fabrication of an ultra-high sensitivity PET scanner, which can be used to detect much smaller lesions than is currently possible. In addition it can be used to perform kinetic modeling of physiological parameters across the entire body, which can be used to better characterize pathological conditions. It can be used to perform low-dose longitudinal PET studies. It can also be used to determine drug kinetics and targeting early in the drug development pipeline.

描述（由申请人提供）：本申请的总体目标是开发用于构建超大轴向视野PET扫描仪的使能技术，其有效性能比现有系统高100倍。具体目标：我们将（1）使用模拟来指定空间分辨率和飞行时间能力，这将实现预白化信噪比平方的100倍增加;（2）与临床建立对话 （3）设计、制造和表征符合目标1中规定性能的探测器;（4）开发新的因子分解、并行重建方法，以有效和可扩展的方式处理来自扫描仪的数据集;（5）创建能够支持超灵敏PET扫描仪的电子系统的精确模拟，并对最终设计方案进行建模（6）完整设备制造的完整规划和成本计算。方法：将使用蒙特-卡罗模拟来规定扫描仪要求。将制造和测试基于现有基于探测器的方法的2种变体的探测器。将举行一个研讨会，临床研究人员和调查人员可以讨论与该项目有关的设计问题。基于开源OpenPET套件和东芝医疗提供的设计的电子配置将在软件中准确模拟，并与Aim 2中内置的探测器一起测试其性能。然后，调查人员将最终确定扫描仪的设计，计算成本，并申请资金完成该项目。从长远来看，扫描仪将被安置在国家超灵敏PET设施中，并提供给来自全国各地的学术和工业研究人员。健康相关性：这一应用将为超高灵敏度PET扫描仪的制造奠定基础，该扫描仪可用于检测比目前可能的小得多的病变。此外，它还可用于对整个身体的生理参数进行动力学建模，从而更好地表征病理状况。它可用于进行低剂量纵向PET研究。它还可用于在药物开发管道的早期确定药物动力学和靶向。 公共卫生相关性：这一应用将为超高灵敏度PET扫描仪的制造奠定基础，该扫描仪可用于检测比目前可能的小得多的病变。此外，它还可用于对整个身体的生理参数进行动力学建模，从而更好地表征病理状况。它可用于进行低剂量纵向PET研究。它还可用于在药物开发管道的早期确定药物动力学和靶向。