Enabling technologies for ultra-high sensitivity PET scanners (PQ13)

超高灵敏度 PET 扫描仪的支持技术 (PQ13)

• 批准号: 8702118
• 负责人: RAMSEY D. BADAWI
• 金额: $ 49.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702118
• 关键词: Accounting; Address; Architecture; Clinical; Communities; Computer software; Country; Data Set; Development; Devices; Dose; Drug Kinetics; Drug Targeting; Educational workshop; Electronics; Ensure; Facility Accesses; Funding; Goals; Health; Housing; Image; Kinetics; Laboratories; Length; Lesion; Medical; Medical Research; Memory; Methods; Metric; Modeling; Monte Carlo Method; Noise; Performance; Physiological; Positron-Emission Tomography; Public Domains; Research; Research Institute; Research Personnel; Resolution; Signal Transduction; Simulate; Solid; Specific qualifier value; System; Techniques; Technology; Testing; Time; To specify; Variant; Work; base; cost; data acquisition; density; design; detector; drug development; image reconstruction; improved; instrumentation; longitudinal positron emission tomography; meetings; meter; novel strategies; open source; radiotracer; reconstruction; simulation; usability

DESCRIPTION (provided by applicant): The overall goal of this application is to develop enabling technologies for the construction of a very large axial field of view PET scanner with effective performance 100-fold greater than existing systems. Specific Aims: We will (1) use simulations to specify spatial resolution and time of flight capabilities that will achieve 100-fol increase in the square of the pre-whitening signal to noise ratio; (2) Build a dialog with clinical researchers to specify requirements and trade-offs for a useful complete device; (3) Design, fabricate and characterize detectors that meet the performance specified in Aim 1; (4) Develop new factorized, parallelized reconstruction methods that can handle the datasets from the scanner in an efficient and scalable manner; (5) Create accurate simulations of electronics systems capable of supporting the ultra-sensitive PET scanner and model the final design options (6) complete planning and costing for the fabrication of the complete device. Methods: Monte-Carlo simulations will be used to specify scanner requirements. Detectors based on 2 variants of existing scintillator-based approaches will be fabricated and tested. A workshop will be held at which clinical researchers and investigators can discuss design issues relating to the project will be held. Electronics configurations based on the open source OpenPET suite and on designs provided by Toshiba Medical will be accurately simulated in software and their performance in conjunction with the detectors built in Aim 2 tested. The investigators will then finalize a design for the scanner, cost it out and apply for funds to complete the project. In the long term, the scanner will be housed in a National Ultra-sensitive PET Facility and access given to academic and industrial researchers from across the country. Health-relatedness: This application will lay the ground-work for the fabrication of an ultra-high sensitivity PET scanner, which can be used to detect much smaller lesions than is currently possible. In addition it can be used to perform kinetic modeling of physiological parameters across the entire body, which can be used to better characterize pathological conditions. It can be used to perform low-dose longitudinal PET studies. It can also be used to determine drug kinetics and targeting early in the drug development pipeline.

描述（由申请人提供）：本申请的总体目标是开发启用技术，以构建一个非常大的轴向视野PET扫描仪，其有效性能比现有系统高100倍。具体目的：我们将（1）使用仿真来指定飞行能力的空间分辨率和时间的时间，这些分辨率和时间将实现100英寸的噪声信号与噪声比的平方增加； （2）与临床建立对话框 研究人员为有用的完整设备指定要求和权衡； （3）设计，捏造和表征符合AIM 1中指定性能的检测器； （4）开发新的分解的，并行的重建方法，可以以有效且可扩展的方式从扫描仪中处理数据集； （5）对能够支持超敏感的PET扫描仪并建模最终设计选项（6）完整的计划和成本成本来制定完整设备的完整计划和成本量的电子系统的准确模拟。方法：将使用蒙特卡罗模拟来指定扫描仪的要求。将制造和测试基于现有基于闪烁体的方法的2个变体的检测器。将举行一个研讨会，临床研究人员和研究人员可以讨论与该项目有关的设计问题。基于开源OpenPET套件和Toshiba Medical提供的设计的电子配置将在软件中准确模拟及其在AIM 2中构建的探测器结合使用。然后，调查人员将最终确定扫描仪的设计，花费并申请资金来完成该项目。从长远来看，该扫描仪将安置在国家超敏感的宠物设施中，并可以访问来自全国各地的学术和工业研究人员。与健康相关性：此应用将为制造超高敏感性PET扫描仪的制造奠定基础，可用于检测比目前可能更小的病变。此外，它可用于对整个身体的生理参数进行动力学建模，可用于更好地表征病理状况。它可用于进行低剂量的纵向宠物研究。它也可以用于确定药物动力学和在药物开发管道中的早期靶向。

项目成果

Performance assessment of a software-based coincidence processor for the EXPLORER total-body PET scanner.

• DOI: 10.1088/1361-6560/aadd3c
• 发表时间: 2018-09-19
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Leung EK;Judenhofer MS;Cherry SR;Badawi RD
• 通讯作者: Badawi RD

Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation.

• DOI: 10.1088/0031-9155/59/8/2023
• 发表时间: 2014-04-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Roncali E;Schmall JP;Viswanath V;Berg E;Cherry SR
• 通讯作者: Cherry SR

Ultra staging to unmask the prescribing of adjuvant therapy in cancer patients: the future opportunity to image micrometastases using total-body 18F-FDG PET scanning.

• DOI: 10.2967/jnumed.113.133892
• 发表时间: 2014-04
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Price PM;Badawi RD;Cherry SR;Jones T
• 通讯作者: Jones T

Parallax error in long-axial field-of-view PET scanners-a simulation study.

• DOI: 10.1088/0031-9155/61/14/5443
• 发表时间: 2016-07-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Schmall JP;Karp JS;Werner M;Surti S
• 通讯作者: Surti S