Training Program in the Neurobiology of Substance Use and Abuse

摘要： 这项申请寻求资金，以解决匹兹堡大学一个连贯的 药物使用和滥用的神经生物学培训计划。该计划将支持三个职位 博士实习生和三名博士前实习生在论文阶段。它是围绕五个核心构建的 培训教师的专长领域：1)动机行为和认知的系统神经生物学2) 青少年发育生物学与物质使用脆弱性3)分子调控 神经递质释放和再摄取4)尼古丁强化和复发5)应激反应脑 电路。一门讲授课程将针对这些核心焦点领域。此外，还将举行正式的系列研讨会 将工作处于前沿研究的杰出科学家吸引到这些重点领域。 在助学金写作方面的广泛培训通过“辅导和审查”助学金写作正式纳入。 课程要求。演示和分析技能将通过一系列的内部研讨会在 哪些正在进行的工作将由受训人员或匹兹堡大学内的其他个人介绍 物质使用研究社区。培训计划将加强成功所需的关键技能，因为 独立调查人员及其组成部分的总和将创建多个节点之间的交互 研究人员，从而增加了受资助个人的培训广度和质量。

Abstract: This application seeks funding to address the opportunity at the University of Pittsburgh for a coherent training program on the neurobiology of substance use and abuse. The program will support three post- doctoral trainees and three pre-doctoral trainees at the dissertation stage. It is structured around five core areas of training faculty expertise: 1) Systems neurobiology of motivated behavior and cognition 2) Adolescent developmental biology and substance use vulnerability 3) Molecular modulation of neurotransmitter release and reuptake 4) Nicotine reinforcement and relapse 5) Stress responsive brain circuits. A didactic course will address these core areas of focus. There will also be a formal seminar series drawing prominent scientists whose work is at the cutting edge of research into these areas of focus. Extensive training in grant writing is formally incorporated through a "mentored and reviewed" grant writing course requirement. Presentation and analysis skills will be developed through an in-house seminar series in which works in progress will be presented by trainees or other individuals within the University of Pittsburgh substance use research community. The training program will enhance critical skills necessary for success as independent investigators, and the sum of its components will create multiple nodes of interaction between researchers, thereby increasing the breadth and quality of training of the supported individuals.