Training Program in the Neurobiology of Substance Use and Abuse

摘要： 此应用程序寻求资金，以解决在匹兹堡大学的机会，为一个连贯的 关于药物使用和滥用的神经生物学培训方案。该计划将支持三个职位- 博士生和三名博士预科生在论文阶段。它围绕着五个核心 培训教师的专业知识领域：1）动机行为和认知的系统神经生物学2） 青少年发育生物学和物质使用脆弱性3） 神经递质释放和再摄取4）尼古丁强化和复发5）应激反应脑 电路.一个教学课程将解决这些核心领域的重点。还将举办正式的系列研讨会 吸引那些在这些重点领域研究前沿的杰出科学家。 通过“指导和审查”的赠款写作，将赠款写作方面的广泛培训正式纳入 课程要求将通过以下一系列的内部研讨会来提高演讲和分析技能： 正在进行的工作将由匹兹堡大学的学员或其他个人提出 物质使用研究社区。培训计划将提高成功所需的关键技能， 独立调查员，其组成部分的总和将创造多个互动节点， 研究人员，从而提高了培训的广度和质量的支持个人。

Abstract: This application seeks funding to address the opportunity at the University of Pittsburgh for a coherent training program on the neurobiology of substance use and abuse. The program will support three post- doctoral trainees and three pre-doctoral trainees at the dissertation stage. It is structured around five core areas of training faculty expertise: 1) Systems neurobiology of motivated behavior and cognition 2) Adolescent developmental biology and substance use vulnerability 3) Molecular modulation of neurotransmitter release and reuptake 4) Nicotine reinforcement and relapse 5) Stress responsive brain circuits. A didactic course will address these core areas of focus. There will also be a formal seminar series drawing prominent scientists whose work is at the cutting edge of research into these areas of focus. Extensive training in grant writing is formally incorporated through a "mentored and reviewed" grant writing course requirement. Presentation and analysis skills will be developed through an in-house seminar series in which works in progress will be presented by trainees or other individuals within the University of Pittsburgh substance use research community. The training program will enhance critical skills necessary for success as independent investigators, and the sum of its components will create multiple nodes of interaction between researchers, thereby increasing the breadth and quality of training of the supported individuals.