Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche

动态果蝇卵巢生态位中上皮干细胞竞争的建模

• 批准号: 8509233
• 负责人: Todd Nystul
• 金额: $ 2.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509233
• 关键词: Aptitude; Biology; Cells; Communities; Data; Doctor of Philosophy; Drosophila genus; EGF gene; Epithelial; Fellowship; Fibroblast Growth Factor; Grant; Hispanic Americans; Hispanics; Left; Modeling; National Institute of General Medical Sciences; Ovarian; Ovary; Pathway interactions; Preparation; Process; Regulation; Research; Schools; Signal Transduction; Stem cells; Testing; Time; Work; abstracting; experience; graduate student; member; novel; peer; pre-doctoral; programs; role model; stem cell fate

Abstract Angela Castanieto is a strong candidate for the NIGMS Diversity Supplements Program. She is an Hispanic-American graduate student in the UCSF Tetrad PhD program and has already demonstrated an outstanding aptitude for scientific research. In addition, she is very involved with the UCSF community at large and specifically within the Hispanic community at UCSF as a founding member of the UCSF SACNAS chapter. This provides her with the opportunity to interact with people from diverse backgrounds, both as a mentee and a role model. Although Ms. Castanieto is currently in her third year of graduate school, and thus further into her program than the typical candidate for the Diversity Supplements Program, extenuating circumstances have delayed her progress. She arrived at UCSF through a non-traditional path that left her with less experience and preparation in biology than her peers. As a result, she had to retake two of her major first year courses in her second year, and postpone her TA duties until her third year. Unlike her classmates, who started working on their research full-time over a year ago, Ms. Castanieto just completed the last of her nonresearch requirements in December, 2011. Nonetheless, during her short time in the lab, she has obtained compelling preliminary data that suggest a novel mechanism for the regulation of the epithelial stem cell fate in the Drosophila ovary. A one-year supplement would provide Ms. Castanieto with the means to develop her project to the point where she would be competitive for independent support, through mechanisms such as an F31 predoctoral fellowship. Thus, we are requesting a supplement for my R01, titled ¿Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche,¿ Grant number 5R01GM097158-02.

摘要 Angela Castanieto是NIGMS多样性补充计划的有力候选人。她是加州大学旧金山分校Tetrad博士项目的一名拉美裔美国研究生，已经展示了出色的科学研究天赋。此外，作为加州大学洛杉矶分校SACNAS分会的创始成员，她非常参与加州大学旧金山分校的整个社区，特别是在加州大学洛杉矶分校的西班牙裔社区。这为她提供了与来自不同背景的人互动的机会，无论是作为学员还是榜样。尽管卡斯塔涅托目前正在读研究生三年级，因此比起多样性补充计划的典型候选人，她的计划更深入了，但情有可原的情况延缓了她的进步。她是通过一条非传统的道路来到加州大学旧金山分校的，这让她在生物学方面的经验和准备比她的同龄人少。结果，她不得不在第二年重修两门第一年的主修课程，并将助教职责推迟到第三年。与一年多前开始全职从事研究的同学不同，卡斯塔涅托在2011年12月刚刚完成了最后一项非研究要求。尽管如此，在她短暂的实验室时间里，她已经获得了令人信服的初步数据，这些数据表明了一种调控果蝇卵巢上皮干细胞命运的新机制。为期一年的补助金将为Castanieto女士提供发展她的项目的手段，使她能够通过F31博士前奖学金等机制获得独立支持。因此，我们要求对我的R01进行补充，题为在动态的果蝇卵巢利基中建立上皮干细胞竞争模型，批准号5R01GM097158-02。