Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche

摘要 安吉拉·卡斯塔涅托是NIGMS多样性补充计划的有力候选人。她是UCSF Tetrad博士课程的西班牙裔美国研究生，已经表现出杰出的科学研究能力。此外，她是非常参与与UCSF社区在广大和特别是在UCSF的西班牙裔社区作为UCSF SACNAS章的创始成员。这为她提供了与来自不同背景的人互动的机会，无论是作为学员还是榜样。虽然Castanieto女士目前正在读研究生三年级，因此比多样性补充项目的典型候选人更深入她的项目，但情有可原的情况推迟了她的进展。她通过非传统的途径来到加州大学旧金山分校，这使她在生物学方面的经验和准备比同龄人少。因此，她不得不在第二年重新学习两门大一的专业课程，并将助教的职责推迟到第三年。与她的同学们不同，他们一年多前就开始全职研究，卡斯塔涅托女士在2011年12月刚刚完成了她最后一项非研究要求。尽管如此，在她在实验室的短暂时间里，她已经获得了令人信服的初步数据，这些数据表明了一种调节果蝇卵巢上皮干细胞命运的新机制。为期一年的补助金将为卡斯塔涅托女士提供发展其项目的手段，使她能够通过F31博士前研究金等机制，有竞争力地获得独立支助。因此，我们正在申请对我的R 01的补充，标题为<$Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche，<$Grant number 5 R 01 GM 097158 -02。

Abstract Angela Castanieto is a strong candidate for the NIGMS Diversity Supplements Program. She is an Hispanic-American graduate student in the UCSF Tetrad PhD program and has already demonstrated an outstanding aptitude for scientific research. In addition, she is very involved with the UCSF community at large and specifically within the Hispanic community at UCSF as a founding member of the UCSF SACNAS chapter. This provides her with the opportunity to interact with people from diverse backgrounds, both as a mentee and a role model. Although Ms. Castanieto is currently in her third year of graduate school, and thus further into her program than the typical candidate for the Diversity Supplements Program, extenuating circumstances have delayed her progress. She arrived at UCSF through a non-traditional path that left her with less experience and preparation in biology than her peers. As a result, she had to retake two of her major first year courses in her second year, and postpone her TA duties until her third year. Unlike her classmates, who started working on their research full-time over a year ago, Ms. Castanieto just completed the last of her nonresearch requirements in December, 2011. Nonetheless, during her short time in the lab, she has obtained compelling preliminary data that suggest a novel mechanism for the regulation of the epithelial stem cell fate in the Drosophila ovary. A one-year supplement would provide Ms. Castanieto with the means to develop her project to the point where she would be competitive for independent support, through mechanisms such as an F31 predoctoral fellowship. Thus, we are requesting a supplement for my R01, titled ¿Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche,¿ Grant number 5R01GM097158-02.