Predoctoral Training in Developmental Biology

项目总结 我们寻求继续支持每年在发育和干细胞领域培训12名博士前学生 加州大学旧金山分校生物学(DSCB)研究生课程。DSCB项目建立在细胞生物学的基础上， 生物化学和遗传学向学生灌输对发育和发育障碍的深刻理解。作为 发育生物学领域正在飞速发展，我们为我们的学生提供了一个充满活力、跨学科的 结合了最新的概念和实验进展的教育。我们的学生获得了 对发育生物学做出开创性贡献的概念和技能，正如他们的 开创性的发现和成功的科学事业。DSCB是一个授予学位的跨校园毕业生 由执行委员会管理并由一名董事和一名副董事管理的计划。63名教职员工 19个基础科学和临床科室的成员参加了该计划。教职员工在 拥有活跃的研究实验室，并为DSCB学生提供广泛的指导。 实验室和受训者之间的互动通过年度静修、研讨会、年度学员- 举办研讨会、两个周刊俱乐部、教师研究讲座、联合研究会议和分享学生 监督。从1994年到2010年，这笔培训补助金资助了学习发育生物学的学生。 通过两个更广泛的研究生课程。2011年，DSCB作为一个独立的研究生项目成立 有自己的招生和自己的课程。从那时起，DSCB在两个方面都有了戏剧性的增长 教职员工(35至62人)和学生(6至46人，2018年秋季增至54人)。学生团体已经成为 日益多样化和最高水平。学生们从蓬勃发展的论文研究实验室和 致力于研究生教育的优秀教师。在上一个资助期内，我们继续 做出改变，以进一步加强培训体验。这些变化包括：(1)更新 课程包括更加强调批判性思维、严格的实验设计、量化和 对数据进行可靠的统计解释、可视化和书面解释。(2)提供更多机会 开发、撰写、演示和辩护建议的项目，(3)新的导师培训重点，(4)更多 支持导航论文年份，(5)开发帮助学生确定和执行的程序 理想的职业道路，(6)教师对研究生课程所有活动的参与，(7)更稳健 行政支持，以及(8)在研究中更全面地开展负责任的行为培训。取得的成功 该方案得到了受训者在培训期间和之后的结果的很好支持，培训期间和之后的培训定期 衡量、总结并透明地在社区内外展示。认识到 在取得成功后，加州大学旧金山分校继续在财务和行政方面扩大对该项目的承诺。 这项培训补助金的续期将支持DSCB学生的智力发展，确保每个 研究生是一位独立的科学家，他帮助领导未来几十年的发育生物学领域。

PROJECT SUMMARY We seek to renew support for training 12 predoctoral students per year in the Developmental and Stem Cell Biology (DSCB) Graduate Program at UCSF. The DSCB program builds off of a foundation of cell biology, biochemistry and genetics to instill deep understanding of development and developmental disorders. As the field of developmental biology is rapidly advancing, we provide our students a dynamic, interdisciplinary education that incorporates the most recent conceptual and experimental advances. Our students acquire the concepts and skills to make groundbreaking contributions to developmental biology, as evidenced by their pioneering discoveries and successful scientific careers. DSCB is a degree-granting, cross-campus graduate program governed by an Executive Committee and run by a Director and an Associate Director. 63 faculty members in 19 basic science and clinical departments participate in the program. The faculty are leaders in their respective fields, have active research laboratories, and provide extensive mentorship to DSCB students. Interactions among laboratories and trainees are facilitated by an annual retreat, seminars, an annual student- run symposium, two weekly journal clubs, faculty research talks, joint research meetings, and shared student supervision. From 1994-2010, this training grant supported students who studied developmental biology through two broader graduate programs. In 2011, DSCB was established as an independent graduate program with its own admissions and its own curriculum. Since then, DSCB has grown dramatically both in terms of faculty (35 to 62) and students (6 to 46, increasing to 54 in Fall 2018). The student body has become increasingly diverse and of the highest caliber. Students chose from thriving thesis research laboratories and faculty dedicated to excellence in graduate education. During the last funding period, we have continued to make changes in order to further strengthen the training experience. These changes include: (1) updating of the curriculum to include greater emphasis on critical thinking, rigorous experimental design, quantitative and statistically sound interpretation, visualization and written interpretation of data. (2) more opportunities to develop, write, present, and defend proposed projects, (3) new emphasis on mentorship training, (4) more support in navigating dissertation years, (5) development of programs to help students determine and execute desired career path, (6) involvement of faculty across all activities of graduate program, (7) more robust administrative support, and (8) more fully developed training in responsible conduct in research. Success of the program is well supported by outcomes of trainees both during and following training, which are regularly measured, summarized, and transparently presented both inside and outside the community. Recognizing the success, UCSF has continued to expand its commitment to the program both financially and administratively. Renewal of this training grant will support the intellectual growth of DSCB students, ensuring that each graduate is an independent scientist who helps lead the field of developmental biology for decades to come.