4th NIH Roadmap Meeting on Membrane Protein Structures and Complexes

第四届 NIH 膜蛋白结构和复合物路线图会议

• 批准号: 8458828
• 负责人: Robert M Stroud
• 金额: $ 2.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458828
• 关键词: Address; Area; California; Cell physiology; Charge; Coffee; Collaborations; Congresses; Consensus; Educational workshop; Family; Funding; Grant; International; Journals; Laws; Length; Marketing; Membrane Proteins; National Institute of General Medical Sciences; Participant; Phase; Physiological Processes; Play; Process; Production; Protein Structure Initiative; Proteins; Publications; Request for Proposals; Research; Research Institute; Research Personnel; Role; San Francisco; Structure; Technology; Training Programs; United States National Institutes of Health; Universities; abstracting; catalyst; indexing; innovation; meetings; member; new technology; posters; programs; protein complex; protein structure; structural biology; symposium

DESCRIPTION (provided by applicant): This proposal requests funds to support the 4th NIH Roadmap Membrane Protein Structure and Technologies Conference. The NIH Roadmap Initiative was created to focus short term on critically important, transformative, high impact, an strategically important areas of biomedical importance. Since membrane proteins play such a critical role in so many cellular and physiological processes and are so difficult to express, solubilize and purify, the production of membrane proteins was identified as a serious roadblock to understanding their structure and function and chosen as one of the top Roadmap Initiatives. This initiative is currently funded by NIH-wide support via the NIH Common Fund. The first phase of the Structural Biology Roadmap Initiative focused on creating Centers for Innovation in Membrane Protein Production. Two Centers, each with ~8 PIs, one at University of California at San Francisco (UCSF) and the other at The Scripps Research Institute (TSRI), were funded and established in 2004. Because of the potentially transformative information that could be generated and shared, NIH staff initially decided that there should be an annual inter-Center meeting between the Centers. The first Inter- Center meeting was hosted by Robert Stroud at UCSF in May, 2006. Since then the NIH Common Fund membrane protein focus has been expanded. To date, 41 grants have been funded through this mechanism. The 2006 meeting was followed by 3 meetings with all Roadmap awardees contributing, hosted alternately by Ray Stevens at TSRI (11/2007) by Robert Stroud at UCSF (3/2009) and by Ray Stevens at LaJolla Shores (11/2010). These NIH Roadmap Membrane Protein Structure and Technologies Conferences became the primary forum for exchanging technologies for membrane proteins in a critical phase of a rapidly developing field. New families of membrane protein structures emerged through the program. The conference became extremely popular and numbers of attendees had to be limited in 2010. The 4th conference, hosted by Robert Stroud, is planned for November 28-30, 2012 at the Westin Market Street Hotel in San Francisco with workshops at UCSF on November 27th. This venue allows expansion of the number of participants to 250 attendees, and provides conference facilities where talks and poster presentations, as well as breakfast, lunch and coffee breaks are in adjacent spaces to encourage discussion and conversation during breaks. The length of the meeting is also extended from 1 1/2 days to 2 1/2 days to allow more participants to attend and present. The meeting will provide a unique opportunity for membrane protein biologists, members of all the projects funded through the RFA Membrane Protein Production and Structure Determination and members of the 9 Membrane Protein Centers funded by the Protein Structure initiative to discuss the current status of their projects. The meeting will also be open to other NIH funded researchers for attendance and abstract consideration for the program. PUBLIC HEALTH RELEVANCE: This proposal requests funds to support the 4th NIH Roadmap/Common Fund Membrane Protein Structure and Technologies Conference planned for November 28-30, 2012 in San Francisco. The length of the conference has been extended and the number of attendees has been expanded to accommodate all membrane protein researchers funded by the NIH Common Fund and Protein Structure Initiative and to open the meeting to other NIH funded PIs. Presentation and discussion will deal with progress as well as barriers to progress that could transform membrane protein structure determination.

描述（由申请人提供）：该提案要求资金支持第四届NIH路线图膜蛋白结构和技术会议。NIH路线图计划的创建是为了在短期内专注于至关重要的，变革性的，高影响力的，具有生物医学重要性的战略重要领域。由于膜蛋白在许多细胞和生理过程中起着如此关键的作用，并且难以表达，溶解和纯化，因此膜蛋白的生产被认为是理解其结构和功能的严重障碍，并被选为顶级路线图计划之一。该计划目前通过NIH共同基金得到了NIH范围内的支持。结构生物学路线图计划的第一阶段重点是创建膜蛋白生产创新中心。两个中心，每个有8个PI，一个在弗朗西斯科加州大学（UCSF），另一个在斯克里普斯研究所（TSRI），是在2004年资助和成立的。由于可以生成和共享潜在的变革性信息，NIH工作人员最初决定在中心之间举行年度中心间会议。2006年5月，罗伯特·斯特劳德在加州大学旧金山分校主持了第一次中心间会议.从那时起，NIH共同基金膜蛋白的重点已经扩大。迄今为止，通过这一机制已资助了41笔赠款。2006年的会议之后是3次会议，所有路线图获奖者作出贡献，轮流主持雷史蒂文斯在TSRI（11/2007）由罗伯特斯特劳德在加州大学旧金山分校（3/2009）和雷史蒂文斯在拉霍亚海岸（11/2010）。这些NIH路线图膜蛋白结构和技术会议成为在一个快速发展的领域的关键阶段交换膜蛋白技术的主要论坛。通过该计划出现了新的膜蛋白结构家族。该会议非常受欢迎，2010年不得不限制与会者人数。 第四次会议，由罗伯特斯特劳德主办，计划于2012年11月28日至30日在威斯汀市场街酒店在旧金山弗朗西斯科与研讨会在加州大学旧金山分校11月27日。该场地允许将与会者人数扩大到250人，并提供会议设施，在相邻的空间内进行演讲和海报展示，以及早餐，午餐和咖啡休息，以鼓励休息期间的讨论和对话。会议的时间也从一天半延长到两天半，以便更多的与会者出席和出席。会议将为膜蛋白生物学家，通过RFA膜蛋白生产和结构测定资助的所有项目的成员以及由蛋白质结构倡议资助的9个膜蛋白中心的成员提供一个独特的机会，以讨论其项目的现状。会议也将开放给其他NIH资助的研究人员出席和抽象的考虑程序。 公共卫生相关性：该提案要求资金支持计划于2012年11月28日至30日在旧金山弗朗西斯科举行的第四届NIH路线图/共同基金膜蛋白结构和技术会议。会议的长度已经延长，与会者的数量已经扩大，以容纳由NIH共同基金和蛋白质结构倡议资助的所有膜蛋白研究人员，并向其他NIH资助的PI开放会议。介绍和讨论将处理的进展，以及进展的障碍，可以改变膜蛋白结构的测定。