4th NIH Roadmap Meeting on Membrane Protein Structures and Complexes

第四届 NIH 膜蛋白结构和复合物路线图会议

• 批准号: 8458828
• 负责人: Robert M Stroud
• 金额: $ 2.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458828
• 关键词: Address; Area; California; Cell physiology; Charge; Coffee; Collaborations; Congresses; Consensus; Educational workshop; Family; Funding; Grant; International; Journals; Laws; Length; Marketing; Membrane Proteins; National Institute of General Medical Sciences; Participant; Phase; Physiological Processes; Play; Process; Production; Protein Structure Initiative; Proteins; Publications; Request for Proposals; Research; Research Institute; Research Personnel; Role; San Francisco; Structure; Technology; Training Programs; United States National Institutes of Health; Universities; abstracting; catalyst; indexing; innovation; meetings; member; new technology; posters; programs; protein complex; protein structure; structural biology; symposium

DESCRIPTION (provided by applicant): This proposal requests funds to support the 4th NIH Roadmap Membrane Protein Structure and Technologies Conference. The NIH Roadmap Initiative was created to focus short term on critically important, transformative, high impact, an strategically important areas of biomedical importance. Since membrane proteins play such a critical role in so many cellular and physiological processes and are so difficult to express, solubilize and purify, the production of membrane proteins was identified as a serious roadblock to understanding their structure and function and chosen as one of the top Roadmap Initiatives. This initiative is currently funded by NIH-wide support via the NIH Common Fund. The first phase of the Structural Biology Roadmap Initiative focused on creating Centers for Innovation in Membrane Protein Production. Two Centers, each with ~8 PIs, one at University of California at San Francisco (UCSF) and the other at The Scripps Research Institute (TSRI), were funded and established in 2004. Because of the potentially transformative information that could be generated and shared, NIH staff initially decided that there should be an annual inter-Center meeting between the Centers. The first Inter- Center meeting was hosted by Robert Stroud at UCSF in May, 2006. Since then the NIH Common Fund membrane protein focus has been expanded. To date, 41 grants have been funded through this mechanism. The 2006 meeting was followed by 3 meetings with all Roadmap awardees contributing, hosted alternately by Ray Stevens at TSRI (11/2007) by Robert Stroud at UCSF (3/2009) and by Ray Stevens at LaJolla Shores (11/2010). These NIH Roadmap Membrane Protein Structure and Technologies Conferences became the primary forum for exchanging technologies for membrane proteins in a critical phase of a rapidly developing field. New families of membrane protein structures emerged through the program. The conference became extremely popular and numbers of attendees had to be limited in 2010. The 4th conference, hosted by Robert Stroud, is planned for November 28-30, 2012 at the Westin Market Street Hotel in San Francisco with workshops at UCSF on November 27th. This venue allows expansion of the number of participants to 250 attendees, and provides conference facilities where talks and poster presentations, as well as breakfast, lunch and coffee breaks are in adjacent spaces to encourage discussion and conversation during breaks. The length of the meeting is also extended from 1 1/2 days to 2 1/2 days to allow more participants to attend and present. The meeting will provide a unique opportunity for membrane protein biologists, members of all the projects funded through the RFA Membrane Protein Production and Structure Determination and members of the 9 Membrane Protein Centers funded by the Protein Structure initiative to discuss the current status of their projects. The meeting will also be open to other NIH funded researchers for attendance and abstract consideration for the program. PUBLIC HEALTH RELEVANCE: This proposal requests funds to support the 4th NIH Roadmap/Common Fund Membrane Protein Structure and Technologies Conference planned for November 28-30, 2012 in San Francisco. The length of the conference has been extended and the number of attendees has been expanded to accommodate all membrane protein researchers funded by the NIH Common Fund and Protein Structure Initiative and to open the meeting to other NIH funded PIs. Presentation and discussion will deal with progress as well as barriers to progress that could transform membrane protein structure determination.

描述(由申请者提供)：该提案请求资金支持第四届NIH路线图膜蛋白结构与技术会议。创建NIH路线图计划是为了将短期重点放在极其重要、具有变革性、影响力大、具有重要战略意义的生物医学领域。由于膜蛋白在许多细胞和生理过程中起着至关重要的作用，而且很难表达、溶解和纯化，膜蛋白的生产被认为是理解其结构和功能的严重障碍，并被选为首要路线图倡议之一。这一倡议目前是由国家卫生研究院通过国家卫生研究院共同基金提供的全美卫生研究院的支持。结构生物学路线图倡议的第一阶段侧重于创建膜蛋白生产创新中心。2004年资助并建立了两个中心，每个中心有大约8个个人投资机构，一个在加州大学旧金山分校(UCSF)，另一个在斯克里普斯研究所(TSRI)。由于可能产生和共享的潜在变革性信息，NIH工作人员最初决定在中心之间举行年度中心间会议。2006年5月，罗伯特·斯特劳德在加州大学旧金山分校主持了第一次中心间会议。从那时起，NIH共同基金的膜蛋白重点已经扩大。到目前为止，已有41笔赠款通过这一机制获得资助。2006年会议之后举行了3次会议，所有路线图获得者都做出了贡献，分别由Ray Stevens在TSRI(11/2007)、Robert Stroud在加州大学旧金山分校(3/2009)和Ray Stevens在LaJolla Shores(11/2010)主持。这些NIH路线图膜蛋白结构和技术会议成为在一个快速发展的领域的关键阶段交流膜蛋白技术的主要论坛。通过该计划，出现了新的膜蛋白结构家族。2010年，会议变得非常受欢迎，出席人数不得不受到限制。第四届会议由罗伯特·斯特劳德主持，计划于2012年11月28日至30日在旧金山威斯汀市场街酒店举行，11月27日在加州大学旧金山分校举办研讨会。该场地允许与会者人数扩大到250人，并提供会议设施，在相邻的空间可以进行演讲和海报演示，以及早餐、午餐和咖啡休息时间，以鼓励在休息时间进行讨论和交谈。会议的时间也从一天半延长到两天半，以便更多的与会者出席和发言。这次会议将为膜蛋白生物学家、通过RFA膜蛋白生产和结构确定资助的所有项目的成员以及由蛋白质结构倡议资助的9个膜蛋白中心的成员讨论其项目的现状提供一个独特的机会。会议还将向NIH资助的其他研究人员开放，供他们出席并抽象考虑该计划。 与公共健康相关：该提案要求提供资金，以支持计划于2012年11月28日至30日在旧金山举行的第四届NIH路线图/共同基金膜蛋白结构和技术会议。会议的长度已经延长，与会者的数量已经扩大，以容纳所有由NIH共同基金和蛋白质结构倡议资助的膜蛋白质研究人员，并向其他NIH资助的PIs开放会议。介绍和讨论将涉及可能改变膜蛋白质结构测定的进展以及进展的障碍。