A new hemagglutination method for blood grouping

描述(由申请人提供)：拟议研究的长期目标是开发一种新的定量颗粒凝集技术，以提高血型分析的性能。传统的血凝血型检测方法存在灵敏度低、孵育时间长、主观性强、试剂用量大等缺点。正是在这种背景下，我们建议开发一种新的技术，它摆脱了传统血凝分析的上述限制。所提出的免疫分析是一种使用廉价仪器的灵敏和快速的方法。值得注意的是，该方法为增强和检测不同来源的粒子的凝集作用提供了一种通用的方法，包括胶乳、二氧化硅微粒和生物细胞。

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of blood typing assays. The conventional hemagglutination blood typing assays have serious drawbacks such as limited sensitivity, long time of incubation, subjectivity and large amount of reagents. It is in this context that we propose to develop a new technology, which is free from the aforementioned limitations of the conventional hemagglutination assays. The proposed immunoassay is a sensitive and rapid method that utilizes inexpensive instrumentation. Significantly, the method presents a general approach for enhancement and detection of agglutination of particles of different origin, including latex, silica microparticles, and biologial cells.