ERIN CRC: Molecular Basis of Nontyphoidal Salmonella Emergence

ERIN CRC：非伤寒沙门氏菌出现的分子基础

• 批准号: 8511552
• 负责人: Samuel I Miller
• 金额: $ 107.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-10 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8511552
• 关键词: Affect; Africa; Africa South of the Sahara; Antibiotics; Bacteremia; Biology; Clinical; Developed Countries; Development; Disease; Disease Outbreaks; Enteral; Epidemiology; Food; Gastroenteritis; Geographic Locations; Goals; HIV; Human; Immune; Infection; Intervention; Kenya; Knowledge; Link; Malaria; Molecular; Nutritional status; Pathogenesis; Pathogenicity; Pilot Projects; Population; Prevalence; Prevention; Public Health; Research; Resources; Salmonella; Salmonella infections; Source; United States; Universities; Washington; base; burden of illness; human disease; microbial host; pathogen; programs; therapeutic vaccine

DESCRIPTION (provided by applicant): Salmonella spp. cause a variety of human diseases, including nontyphoidal salmonellosis or NTS. NTS can present as a gastroenteritis, bacteremia, or a carriage state. Most NTS in the United States and developed nations occurs as a self-limited gastroenteritis, typically from contaminated food during specific outbreaks. In contrast, NTS in Africa is increasingly manifesting as a bacteremia without gastroenteritis, and shows human-to-human spread. Evidence suggests that this may be due in part to the immune status of the host populations, including comorbid infections such as HIV and malaria, and/or nutritional status. The goals of the ERIN CRC at the University of Washington will be to understand this difference in epidemiology by elucidating the contribution of microbial, host, and population factors in disease and carriage states. Three projects will be established to 1) examine host/pathogen diversity in clinical cases of NTS in Kenya (Judd Walson, Pl), 2) elucidate the genotypic and phenotypic correlates of pathogenicity in Salmonella strains from Africa and the United States (Sam Miller, PI) and 3) determine the immune correlates and mechanisms of limiting NTS bacteremia in the human host (Brad Cookson, PI). The projects will be coordinated through the efforts of an Administrative Core, which will also establish and manage a Pilot Project program.

描述（由申请人提供）：沙门氏菌属。引起多种人类疾病，包括非细刺鲑鱼类病或NTS。 NTS可以作为胃肠炎，菌血症或托架状态出现。美国和发展中的大多数NT是作为一种自限制的胃炎，通常来自特定暴发期间受污染的食物。相比之下，非洲的NT越来越表现为没有胃炎的菌血症，并显示人类对人类的传播。证据表明，这可能部分是由于宿主种群的免疫状态，包括艾滋病毒和疟疾等合并症和/或营养状况。华盛顿大学ERIN CRC的目标是通过阐明微生物，宿主和人口因素在疾病和马车状态的贡献，了解流行病学的这种差异。将建立三个项目至1）检查肯尼亚NTS临床病例中的宿主/病原体多样性（Judd Walson，pl），2）阐明来自非洲和美国的沙门氏菌菌株中致病性的基因型和表型相关性pi）。这些项目将通过行政核心的努力进行协调，该核心还将建立和管理试点项目计划。