Salmonella pathogenicity island 2 effector proteins

摘要 沙门氏菌是一种兼性胞内病原体，可引起人类和动物的重大疾病。 这些微生物引起几种疾病综合征，包括肠（伤寒）热，胃肠炎， 细菌感染和局部感染。伤寒是一种严重的全身性疾病， 发展中国家和旅行者。在美国，非伤寒沙门氏菌感染正在增加， 主要与受污染的食品有关。沙门氏菌感染在婴儿、老年人和 在免疫抑制的个体中。这项拨款建议研究一组毒力基因，称为沙门氏菌 易位效应物，其穿过吞噬体膜易位到真核细胞中 将研究沙门氏菌致病岛II编码的III型分泌系统对细胞质的影响。这 格兰特建议进一步确定这些蛋白质，并从分子上详细研究它们在细菌毒力中的作用。

ABSTRACT Salmonella are facultative intracellular pathogens which cause significant diseases in humans and animals. These organisms cause several disease syndromes, including enteric (typhoid) fever, gastroenteritis, bacteremias and focal infections. Typhoid fever is a severe systemic illness which is mostly a problem in the developing world and in travelers. Non-typhoidal salmonella infections are increasing in the USA and are largely associated with contaminated food. Salmonellae infections are most severe in infants, the elderly, and in immunosuppressed individuals. This grant proposes to study a set of virulence genes, termed Salmonella translocated effectors, that are translocated across the phagosome membrane into the eucaryotic cell cytoplasm by a type III secretion system encoded on Salmonella pathogenecity island II will be studied. This grant proposes to further define these proteins, and to study in molecular detail their role in bacterial virulence.