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Salmonella pathogenicity island 2 effector proteins

沙门氏菌致病岛2效应蛋白

基本信息

批准号：
9526598
负责人：
Samuel I Miller
金额：
$ 38.76万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9526598
关键词：
Animals Antibiotic Resistance Antibodies Bacteremia Bacteria Binding Binding Proteins CRISPR/Cas technology Cell Line Cells Cholesterol Complex Cytoplasm Data Diarrhea Disease Dominant-Negative Mutation Elderly Enteral Epithelial Cells Eukaryotic Cell Evaluation Focal Infection Food Contamination Funding Gastroenteritis Gene Silencing Genes Genetic Transcription Glycerol Golgi Apparatus Grant Guanosine Triphosphate Phosphohydrolases Hela Cells Homeostasis Human IL8 gene Immune response Immunofluorescence Immunologic Individual Infant Infection Inflammatory Response Integration Host Factors Interleukins Intestines Island Lead Lipid Binding Lipids MAPK14 gene MAPK8 gene Mammalian Cell Mediating Membrane Membrane Lipids Metabolic Mitogen-Activated Protein Kinases Modification Molecular Molecular Weight Movement Organism Pathogenesis Pathogenicity Island Phagosomes Phosphatidylcholine-Sterol O-Acyltransferase Phospholipids Phosphoric Monoester Hydrolases Phosphorylation Production Proteins Psychological reinforcement Recruitment Activity Role SPI1 gene Salmonella Salmonella infections Salmonella typhimurium Signal Transduction Syndrome Technology Testing Tight Junctions Type III Secretion System Pathway Typhoid Fever United States Virulence activating transcription factor experimental study gastrointestinal infection global health immunosuppressed insight lipid biosynthesis macrophage mitogen-activated protein kinase p38 mutant novel therapeutic intervention novel vaccines oxysterol binding protein pathogen phosphatidylinositol 4-phosphate prevent

项目摘要

ABSTRACT Salmonella are facultative intracellular pathogens which cause significant diseases in humans and animals. These organisms cause several disease syndromes, including enteric (typhoid) fever, gastroenteritis, bacteremias and focal infections. Typhoid fever is a severe systemic illness which is mostly a problem in the developing world and in travelers. Non-typhoidal salmonella infections are increasing in the USA and are largely associated with contaminated food. Salmonellae infections are most severe in infants, the elderly, and in immunosuppressed individuals. This grant proposes to study a set of virulence genes, termed Salmonella translocated effectors, that are translocated across the phagosome membrane into the eucaryotic cell cytoplasm by a type III secretion system encoded on Salmonella pathogenecity island II will be studied. This grant proposes to further define these proteins, and to study in molecular detail their role in bacterial virulence.

摘要沙门氏菌是一种兼性胞内病原体，可引起人类和动物的重大疾病。这些微生物引起几种疾病综合征，包括肠（伤寒）热，胃肠炎，细菌感染和局部感染。伤寒是一种严重的全身性疾病，发展中国家和旅行者。在美国，非伤寒沙门氏菌感染正在增加，主要与受污染的食品有关。沙门氏菌感染在婴儿、老年人和在免疫抑制的个体中。这项拨款建议研究一组毒力基因，称为沙门氏菌易位效应物，其穿过吞噬体膜易位到真核细胞中将研究沙门氏菌致病岛II编码的III型分泌系统对细胞质的影响。这格兰特建议进一步确定这些蛋白质，并从分子上详细研究它们在细菌毒力中的作用。