Administration Core

X地区西北地区生物防御和新兴卓越中心 传染病是全国性生物医学研究网络的重要组成部分 抗击传染病对人口威胁的方案。NWRCE目前是一个高度 互动和主题节目，重点是革兰氏阴性细菌病原体。同样的将军 始终如一的关注从一开始就存在。全文共分三个主题：(1)革兰氏阴性杆菌的发病机制 细菌发病机制，(2)对革兰氏阴性细菌病原体的天然免疫反应，以及(3) 将(1)和(2)转化为预防或治疗革兰氏阴性菌的早期治疗开发 细菌性疾病。NWRCE的中心是西雅图的华盛顿大学(UW)；在这次更新中 申请时，建议在西雅图、俄勒冈州、爱达荷州和马里兰州各选址一处。这个 NWRCE自成立以来一直包括NIAID落基山实验室，这种关系将 作为此次更新的一部分继续并发展，因为合作范围扩大到包括图拉热症以及 鼠疫研究。不列颠哥伦比亚省也在我们的地理区域，建议与 不列颠哥伦比亚省维多利亚大学。NWRCE更新提出了三个国际选址：泰国、 瑞典和墨西哥。项目、核心、国内和国际站点以及合作者都高度重视 互动性。组成这项提案的个人在过去的几年里一直在一起工作 在供资期间和为区域经济共同体提供资金之前。大多数调查人员新增加了这一点 申请续期拨款给西北地区经济发展委员会的成员，一直与 中间。NWRCE的互动性和重点是该计划的一大优势，并允许 NWRCE将迅速和灵活地响应国家优先事项，以实现以下方面的重要目标 革兰氏阴性细菌感染。

The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens. The same general consistent focus has existed since its inception. There are three themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. The NWRCE has included the NIAID Rocky Mountain Laboratory since its inception and this relationship will continue and grow as part of this renewal as collaborations are expanded to include tularemia as well as plague research. British Columbia is also in our geographic region and collaboration is proposed with the University of Victoria, British Columbia. The NWRCE renewal proposes three international sites: Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the RCE was funded. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections.