Administration Core

西北地区生物防御和新兴生物技术卓越中心（NWRCE） 传染病是全国性生物医学研究网络的重要组成部分 抗击传染病对人口威胁的方案。NWRCE目前是一个高度 以革兰氏阴性细菌病原体为重点互动和专题方案。相同的一般 自成立以来，一直保持着一贯的重点。本论文的主要内容有三个方面：（1）革兰氏阴性杆菌的致病机制 细菌发病机制，（2）对革兰氏阴性细菌病原体的先天免疫应答，和（3） 将（1）和（2）转化为早期治疗开发，以预防或治疗革兰氏阴性菌 细菌性疾病该NWRCE是集中在华盛顿（UW）在西雅图大学;在这次更新 申请中，在西雅图提出了多个地点，在俄勒冈州提出了两个地点，在爱达荷州提出了一个地点，在马里兰州提出了一个地点。的 NWRCE自成立以来就包括了NIAID落基山实验室，这种关系将 继续和发展，作为这一更新的一部分，合作扩大到包括兔热病以及 瘟疫研究。不列颠哥伦比亚省也在我们的地理区域内， 维多利亚大学，不列颠哥伦比亚省。NWRCE的更新建议三个国际网站：泰国， 瑞典和墨西哥。该项目，核心，国内和国际网站，以及合作者，是高度 互动在过去的几年里，提出这一建议的个人共同努力了许多年。 在RCE获得资助之前和资助期间。大多数研究人员对此进行了新的补充 申请重新资助的NWRCE与成员有长期的合作关系， 中心NWRCE的互动性质和重点是该计划的主要优势，并允许 NWRCE迅速和灵活地应对国家优先事项，以实现以下方面的重要目标： 革兰氏阴性菌感染。

The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens. The same general consistent focus has existed since its inception. There are three themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. The NWRCE has included the NIAID Rocky Mountain Laboratory since its inception and this relationship will continue and grow as part of this renewal as collaborations are expanded to include tularemia as well as plague research. British Columbia is also in our geographic region and collaboration is proposed with the University of Victoria, British Columbia. The NWRCE renewal proposes three international sites: Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the RCE was funded. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections.