2012 and 2014 Lysosomes & Endocytosis Gordon Research Conference

2012 和 2014 溶酶体

• 批准号: 8252386
• 负责人: Michael S Marks
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252386
• 关键词: Academy; Area; Automobile Driving; Award; Baltimore; Biochemistry; Biological Models; Biology; Blood coagulation; Cell Communication; Cell Fractionation; Cellular biology; Clinical; Clinical Investigator; Collaborations; Communicable Diseases; Communication; Communities; Cytokinesis; Data; Defect; Development; Disabled Persons; Disease; Disease Pathway; Doctor of Philosophy; Endocytosis; Endosomes; Environment; Eukaryotic Cell; Event; Fostering; Funding; Genetic; Goals; Growth; Hemostatic function; Hereditary Disease; Hermanski-Pudlak Syndrome; Host Defense; Human; Immune; Immunology; Inflammation; Institutes; International; Investments; Link; Lysosomes; Malignant Neoplasms; Mammalian Cell; Medicine; Membrane Protein Traffic; Metabolism; Microbiology; Mission; Molecular; National Institute of Allergy and Infectious Disease; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Immunity; Nerve Degeneration; Neurosciences; Nobel Prize; Nutrient; Nutritional and Metabolic Diseases; Oral; Organ; Participant; Pathway interactions; Patients; Pennsylvania; Pharmacology; Philadelphia; Physiological; Physiology; Pigmentation physiologic function; Play; Postdoctoral Fellow; Predisposition; Property; Public Health; Recording of previous events; Request for Proposals; Research; Research Personnel; Role; Running; Sampling; Science; Series; Signal Transduction; System; Touch sensation; Travel; Underrepresented Minority; United States National Institutes of Health; Universities; Variant; Woman; Yeasts; abstracting; adaptive immunity; base; cancer cell; cell type; cytotoxicity; extracellular; fly; glucose metabolism; graduate student; interest; lipid metabolism; meetings; neuron development; neuronal patterning; pathogen; posters; prevent; programs; response; skills; symposium; uptake

DESCRIPTION (provided by applicant): This proposal requests funding for partial support for two sequential meetings on Lysosomes and Endocytosis as part of the Gordon Research Conference (GRC) series to be held in Proctor Academy, Andover, NH from June 17th-22nd 2012 and again in June 2014. We also request funding for an associated Gordon Research Seminar (GRS) for 40-50 graduate student and post-doctoral trainees immediately preceding each Conference. The Lysosomes and Endocytosis GRC has a tradition of over forty years as the key international venue for presentation of cutting edge research in the area of membrane traffic in the endocytic pathway and diseases of lysosome biology. The field continues to evolve, with recent advances elucidating roles for the endocytic pathway in new areas such as development, cytokinesis, signaling, innate and adaptive immunity, metabolism, neurodegeneration and genetic disease. Through high quality formal presentations and rigorous poster sessions, the Lysosomes and Endocytosis GRC will highlight these areas and foster the development of new hypotheses, research directions, and collaborations. The GRC will have approximately 150 participants, including at least 40 speakers and 8 discussion leaders representing critical areas in research in endocytosis and lysosome biology, and a keynote speaker with a long history of contributions to the field. The program for 2012 will focus on the molecular underpinnings of the endocytic pathway, the role of endosomes and lysosomes in genetic disease, host-pathogen interactions, adaptive and innate immunity, and metabolism. Ten speakers will be selected from abstracts submitted and one session will be devoted to discussion of new directions. In addition, two poster sessions - each spanning two evenings - will permit all participants to contribute to these topics. The 2014 conference will be organized along distinct lines but will cover many of the same topics, with additional foci on development, neuronal function and cancer. The Lysosomes and Endocytosis GRC represents a highly significant investment for the NIH with interests touching on the mission of multiple Institutes. The requested funds will be used to support travel and registration for invited speakers, discussion leaders and junior investigators. Funds are also requested to support invitees to the associated GRS, in which trainees will be provided with background material and will be encouraged to present their data to each other to build presentation and networking skills. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference and Gordon Research Seminar on Lysosomes and Endocytosis explore fundamental cellular pathways that underlie normal human physiology, disease, and host defense. These pathways control susceptibility to and defense against infectious disease, cellular digestive pathways that malfunction in genetic, neurodegenerative and nutritional metabolic diseases, growth control pathways related to cancer, and cell interaction pathways required for proper development. The conferences bring together top researchers in the field to discuss their latest and most important research findings, and thereby advance public health by exchanging new ideas, establishing new collaborations, and driving future research areas.

描述（由申请人提供）：该提案要求为两次连续的溶酶体和内吞作用会议提供部分支持，作为戈登研究会议（GRC）系列的一部分，将于2012年6月17日至22日在新罕布什尔州安多弗的普罗克特学院举行，并于2014年6月再次举行。我们还要求资助一个相关的戈登研究研讨会（GRS）为40-50研究生和博士后实习生紧接在每次会议之前。溶酶体和内吞GRC有四十多年的传统，是介绍内吞途径和溶酶体生物学疾病中膜交通领域前沿研究的主要国际场所。该领域继续发展，最近的进展阐明了内吞途径在新领域的作用，如发育，胞质分裂，信号传导，先天性和适应性免疫，代谢，神经变性和遗传疾病。通过高质量的正式演讲和严格的海报会议，溶酶体和内吞GRC将突出这些领域，并促进新假设，研究方向和合作的发展。GRC将有大约150名参与者，其中包括至少40名演讲者和8名代表内吞作用和溶酶体生物学研究关键领域的讨论负责人，以及一名对该领域有长期贡献的主旨演讲者。2012年的计划将侧重于内吞途径的分子基础，内体和溶酶体在遗传疾病中的作用，宿主-病原体相互作用，适应性和先天免疫以及代谢。将从提交的摘要中选出10名发言者，并将有一次会议专门讨论新的方向。此外，两次海报会议-每次持续两个晚上-将使所有与会者都能就这些专题发表意见。2014年的会议将沿着不同的路线组织，但将涵盖许多相同的主题，并增加了对发育，神经元功能和癌症的关注。溶酶体和内吞GRC代表了NIH的一项非常重要的投资，涉及多个研究所的使命。所要求的资金将用于支助应邀发言者、讨论带头人和初级调查员的差旅和登记。还要求提供资金，以支助相关全球登记系统的受邀者，向受训者提供背景材料，并鼓励他们相互介绍数据，以培养介绍和建立联系的技能。 公共卫生关系：戈登研究会议和关于溶酶体和内吞作用的戈登研究研讨会探讨了正常人类生理，疾病和宿主防御的基本细胞途径。这些途径控制对传染病的易感性和防御，在遗传、神经退行性和营养代谢疾病中发生故障的细胞消化途径，与癌症相关的生长控制途径，以及正常发育所需的细胞相互作用途径。会议汇集了该领域的顶尖研究人员，讨论他们最新和最重要的研究成果， 从而通过交流新的想法，建立新的合作，推动未来的研究领域来促进公共卫生。