HIV care coordination: comparative effectiveness, outcome determinants and costs

艾滋病毒护理协调：比较有效性、结果决定因素和成本

• 批准号: 8659691
• 负责人: Mary Kathryn Irvine
• 金额: $ 51.53万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659691
• 关键词: AIDS/HIV problem; Achievement; Aftercare; Alcohol or Other Drugs use; Behavioral; Caring; Case Management; Client; Cohort Studies; Communities; Comprehensive Health Care; Cost Savings; Data; Decision Making; Directly Observed Therapy; Early treatment; Effectiveness; Effectiveness of Interventions; Elements; Eligibility Determination; Enrollment; Epidemic; Funding Agency; Goals; HIV; HIV Infections; HIV diagnosis; Health; Health Benefit; Health Promotion; Home environment; Hospitals; Individual; Intervention; Interview; Learning; Life; Location; Long-Term Care; Mental Health; Mental disorders; Modeling; Outcome; Participant; Patients; Persons; Prevention; Program Effectiveness; Public Health; Public Health Schools; Quality-Adjusted Life Years; Recording of previous events; Relative (related person); Research; Research Personnel; Resources; Sampling; Services; Site; Structure; Subgroup; Test Result; Viral Load result; Virus; Visit; Work; antiretroviral therapy; base; biobehavior; college; comparative effectiveness; comparison group; cost; cost effective; cost effectiveness; effective therapy; evidence base; follow-up; high risk; housing instability; improved; intervention program; meetings; outreach; population based; primary outcome; programs; public health relevance; response; scale up; surveillance data; transmission process; treatment as usual; treatment program; uptake

DESCRIPTION (provided by applicant): Significant gaps in HIV diagnosis rates, linkage to and retention in HIV care, timely antiretroviral therapy (ART) initiation, and viral load (VL) suppression among persons living with HIV (PLWH) undermine the potential impact of 'treatment as prevention' and jeopardize achievement of US National HIV/AIDS Strategy (NHAS) goals. There is a significant need for more rigorous evidence regarding the effectiveness of several promising intervention strategies, some of which are already being implemented alone or in combination. In late 2009, the NYC Department of Health and Mental Hygiene (DOHMH) began implementing a comprehensive Care Coordination Program (CCP) at 28 Ryan White-funded agencies, targeting patients at high risk for suboptimal care cascade outcomes. The CCP intervention combines various evidence-based programmatic elements into a package, including case management, patient navigation, directly observed therapy (DOT), structured health promotion in home/field visits, and outreach to assist patients in accessing needed care and related services. The purpose of this retrospective cohort study, led jointly by investigators from the CUNY School of Public Health at Hunter College and the NYCDOHMH, is to: 1) assess the effectiveness of the CCP intervention by comparing primary outcomes among CCP participants with those of similar PLWH in HIV care who do not receive the CCP intervention; 2) among those who enroll in CCP, identify individual and program-level determinants of care engagement and VL suppression up to 36 months following CCP enrollment; and 3) assess the cost-effectiveness (cost per quality-adjusted life year [QALY]) of the CCP relative to usual care outside the CCP, considering downstream cost-savings and individual and public health benefits due to improved VL suppression and HIV infections averted. We expect the proposed research to generate much- needed evidence related to the effectiveness, outcome determinants, and cost-effectiveness of a promising, scalable service delivery strategy, ultimately enabling HIV care programs to further evolve achieve the greatest possible uptake and impact.

描述(由申请人提供)：艾滋病毒诊断率、与艾滋病毒护理的联系和保留、及时开始抗逆转录病毒治疗(ART)以及艾滋病毒携带者(PLWH)中病毒载量(VL)抑制方面的重大差距破坏了‘治疗即预防’的潜在影响，并危及美国国家艾滋病毒/艾滋病战略(NHAS)目标的实现。有必要就几种有希望的干预战略的有效性提供更严格的证据，其中一些战略已经单独或联合实施。2009年底，纽约市卫生和精神卫生部门(DOHMH)开始在瑞安·怀特资助的28家机构实施全面的护理协调计划(CCP)，针对高风险患者，以获得次优的护理级联结果。CCP干预将各种以循证为基础的方案要素结合在一起，包括病例管理、患者导航、直接观察治疗(DOT)、在家庭/实地访问中进行系统的健康促进，以及帮助患者获得所需护理和相关服务的外联。这项由亨特学院纽约州立大学公共卫生学院和NYCDOHMH的研究人员共同领导的回溯性队列研究的目的是：1)通过比较CCP参与者和未接受CCP干预的艾滋病毒护理中类似PLWH的主要结果，评估CCP干预的有效性；2)在那些加入CCP的人中，确定在CCP注册后长达36个月的护理参与度和VL抑制的个人和计划层面的决定因素；以及3)评估CCP相对于非CCP的常规护理的成本效益(每质量调整生命年的成本[QALY])，考虑到下游成本节约以及由于改进VL抑制和避免艾滋病毒感染而对个人和公共健康的好处。我们预计拟议的研究将产生与前景看好的、可扩展的服务交付战略的有效性、结果决定因素和成本效益相关的亟需证据，最终使艾滋病毒护理计划能够进一步发展，实现尽可能大的吸收和影响。