Study of Health Outcomes in Children with Autism and Their Families

这项合同修改是为了扩大和补充合同HHSN271201000033C，以符合“自闭症儿童及其家庭健康结局研究”的工作范围，以便访问根据合同开发的目前有效的数据库，以便进行进一步的分析。 自闭症谱系障碍(ASD)是一个重大的公共卫生问题，据估计，美国每88名儿童中就有1名患病率。到目前为止，大部分研究都集中在自闭症的核心社交和沟通缺陷上，但有轶事和一些调查数据表明，在这一人群中，合并健康状况的比率可能也会上升。此外，尽管一些大规模的流行病学研究评估了ASD和疫苗接种之间的任何潜在联系，但公众仍然对这种因果联系感到担忧。至少在一定程度上，美国卫生官员报告称，普通人群中的疫苗拒接率有所上升。 关于自闭症儿童及其家庭健康结果的研究始于两年前。根据这份合同，承包商分析了46,236名自闭症儿童及其父母和兄弟姐妹的回溯性商业健康计划索赔的大型数据集，以及儿童和家庭成员的比较队列。他们成功地完成了最初工作说明中要求的分析，其中包括对索赔数据中自闭症诊断的有效性的研究，以及对自闭症队列、其家庭成员和对照队列的健康结果和保健利用情况的描述。

This contract modification is to extend and supplement Contract HHSN271201000033C, consistent with the scope of work of "Study of Health Outcomes in Children with Autism and Their Families¿ in order to access the currently validated database developed under the contract to provide for further analysis . Autism Spectrum Disorder (ASD) is a significant public health concern, with an estimated prevalence of 1 in 88 children in the United States. Much of the research to date has focused on the core social and communication deficits of ASD, but there are anecdotes and some survey data suggesting that the rate of comorbid health conditions may also be elevated in this population. Furthermore, despite several large-scale epidemiological studies that have assessed but not found any potential association between ASD and vaccinations, public concerns persist about such a causal link. At least partly as a consequence, health officials in the United States have reported an increased rate of vaccine refusal in the general population. The Study of Health Outcomes in Children with Autism and their Families was begun two years ago. Under this contract, the Contractor analyzed a large dataset of retrospective commercial health plan claims of 46,236 children with ASD, their parents and siblings, and a comparison cohort of children and family members. They successfully completed the analyses requested in the original statement of work, which included a study of the validity of ASD diagnoses in the claims data, and descriptions of health outcomes and health care utilization of the ASD cohort, their family members, and the comparison cohorts.