Role of Experience in Development of Cognitive Control and Frontal Cortex

经验在认知控制和额叶皮层发育中的作用

• 批准号: 8421554
• 负责人: DIMA AMSO
• 金额: $ 40.5万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-12 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8421554
• 关键词: Adolescence; Adolescent; Adult; Affect; Age; Algorithms; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Behavioral; Brain; Caregivers; Child; Childhood; Classification; Code; Cognitive; Complex; Data; Decision Making; Dependence; Development; Environment; Environmental Risk Factor; Family; Functional Magnetic Resonance Imaging; Goals; Human; Individual Differences; Learning; Liquid substance; Literature; Magnetic Resonance Imaging; Measures; Modeling; Nature; Patients; Pattern; Performance; Policies; Proxy; Relative (related person); Risk; Role; Sampling Studies; Scanning; Socioeconomic Status; Specificity; Staging; Structure; Testing; Voice; Work; abstracting; age related; base; cognitive control; design; developmental disease; experience; flexibility; frontal lobe; indexing; low socioeconomic status; neuroimaging; novel; peer; relating to nervous system; research study; skills; social; success

DESCRIPTION (provided by applicant): Development is charactarized by increasing flexibility in thought and action, enabeling the generalization of rules from item-specific instances to abstract classes of rules that support flexible behavior and can be generalized to novel situations. We capitalized on an established paradigm that has been effective in charactarizing this skill in adults in behavioral and fMRI experiments, and also in patients with frontal damage. This work has shown that increasing complexity in rule-guided action recruites the frontal cortex along a rostro- caudal axis. We hypothesize here that the functional development of the frontal cortex, from middle childhood to adulthood, and associated behavioral performance will follow the same pattern. Specifically, we predict that mature behavior in simple rule tasks will be evident earlier in development than more complex tasks and that this will be associated with functional effiency at the level of the frontal cortex in caudal prior to rostral regions. Using th extant literature, we predict that this functional development is a reflection of increases in the stability of cortical coding of rule-relevant representations. We test this hypothesis using multi-voxel pattern classification algorithms designed to decode the stability of rule-relevant representations across development. Moreover, we test the prediction that representational stability is dependent on experience. Portions of the frontal cortex have an especially protracted developmental course and have been shown to be susceptible to both positive and negative environmental experiences. Rather than use age as a proxy for experience, we turn to socioeconomic status (SES), which has been shown to be a predictor of cognitive control development. Availability of items, interactions, and experiences in high relative to low SES families may prove relevant for experience-based changes in representational stability at the level of the frontal cortex. Moreover, variability among experiences is necessarily more relevant for the development of abstract rather than concrete rule representations, indicating that the impact of SES differences may be evident specific to the development of abstract rule structures. We will examine the specific contribution of SES, as a proxy for enriching experiences, to the development of rule-guided action in both behavioral and neuroimaging experiments. RELEVANCE Item-specific concreteness and perseveration are ubiquitous in developmental disorders including Autism, ADHD, and OCD. We propose to characterize development of rule use at varying levels of abstraction, allowing for novel specificity in understanding the deveopmental course of these skills. Uncovering a specific relationship with experience-based factors (SES) in this development has the added potential of defining variables that confer risk specific to cognitive flexibility and will inform social and educational policy moving forward. PUBLIC HEALTH RELEVANCE: We focus this work on the development of cognitive control and rule-guided behaviour during the transition from childhood to adolescence and adulthood. This is a period marked by extensive change in the child's environment, including changes in peer relations and increased independence and academic demand. Our aim is to expose the developmental interactions among components of rule-guided behaviour, their functional neural substrates, and the nature and stability of rule-relevant representations coded by the frontal cortex across this developmental period.

描述（由申请人提供）：发展的特点是增加思想和行动的灵活性，使规则的泛化从项目特定的实例到抽象类的规则，支持灵活的行为，并可以推广到新的情况。我们利用了一个已建立的范式，该范式在行为和功能磁共振成像实验中有效地表征了成年人以及额叶损伤患者的这种技能。这项工作表明，规则引导的行动越来越复杂，额叶皮层沿着一个吻尾轴被招募。我们在这里假设，额叶皮层的功能发展，从童年中期到成年，以及相关的行为表现将遵循相同的模式。具体来说，我们预测，在简单的规则任务中的成熟行为将是明显的发展早于更复杂的任务，这将与功能效率在水平的额叶皮层在尾侧前吻侧区域。使用现存的文献，我们预测，这种功能的发展是增加的稳定性的规则相关的表示皮层编码的反映。我们使用多体素模式分类算法来测试这一假设，该算法旨在解码整个开发过程中规则相关表示的稳定性。此外，我们测试的预测，代表性的稳定性是依赖于经验。额叶皮层的某些部分有一个特别漫长的发展过程，并且已经被证明对积极和消极的环境经历都很敏感。而不是使用年龄作为经验的代理，我们转向社会经济地位（SES），这已被证明是认知控制发展的预测因子。可用性的项目，互动和经验，在高相对于低SES的家庭可能会证明相关的经验为基础的变化，在额叶皮层的水平代表稳定性。此外，经验之间的变化必然是更相关的发展，而不是具体的规则表示，表明SES差异的影响可能是明显的具体发展的抽象规则结构。我们将研究SES的具体贡献，作为丰富经验的代理，在行为和神经成像实验中的规则引导的行动的发展。项目特异性具体性和持续性在发育障碍中普遍存在，包括自闭症、ADHD和OCD。我们建议在不同的抽象层次上描述规则使用的发展，从而在理解这些技能的发展过程中获得新的特异性。在这一发展过程中，揭示与基于经验的因素（SES）的特定关系具有额外的潜力，可以定义赋予认知灵活性特定风险的变量，并将为社会和教育提供信息 政策向前推进。 公共卫生关系：我们专注于这项工作的发展，认知控制和规则引导的行为在从童年到青春期和成年的过渡。这一时期的特点是儿童的环境发生了广泛的变化，包括同伴关系的变化以及独立性和学业要求的提高。我们的目标是揭示规则引导行为的组成部分之间的发展相互作用，其功能神经基板，以及在整个发展时期由额叶皮层编码的规则相关表征的性质和稳定性。