1/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes

1/5 物质暴露和早年不幸对儿童健康发展和结果的累积风险

• 批准号: 10194823
• 负责人: DIMA AMSO
• 金额: $ 12.68万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10194823
• 关键词: 2019-nCoV; Address; Affect; Age; Age-Months; Alcohol or Other Drugs use; Birth; Brain; Breast Feeding; COVID-19; COVID-19 pandemic; Caring; Child; Child Development; Child Health; Cognitive; Contracts; Coupled; Data; Databases; Development; Dimensions; Disease Outbreaks; Economics; Employee; Environment; Environmental Risk Factor; Family; Family history of; Fetal Development; Fetus; Fever; Growth; Guidelines; Health; Hydrocephalus; Hyperthermia; Hypoxemia; Image; Income; Individual; Infant; Infection; Inflammation; Inflammatory Response; Intervention; Kangaroo; Lead; Learning; Life; Longitudinal Studies; Low income; Measures; Mediating; Mothers; Nature; Neurocognitive; Neurologic; Newborn Infant; Outcome; Parent-Child Relations; Pattern; Play; Police; Pregnancy; Pregnant Women; Premature Birth; Race; Regression Analysis; Research; Rhode Island; Risk; Risk Factors; Role; Safety; Schools; Services; Severities; Skin; Sleep; Smell Perception; Social Distance; Stress; Stroke; Structure; Support Groups; Symptoms; Taste Perception; Textiles; Time; Uncertainty; Vertical Disease Transmission; Virus; antenatal; antenatal care; cognitive development; cognitive function; cytokine release syndrome; design; early life adversity; economic impact; educational atmosphere; emerging adult; environmental change; environmental stressor; ethnic minority population; experience; fetal; health economics; infection rate; lens; lower income families; maternal stress; neonate; neurodevelopment; neuroimaging; novel coronavirus; nutrition; physical conditioning; postnatal; psychosocial; racial and ethnic; racial minority; recruit; sleep health; sleep quality; social; sociodemographics; socioeconomics; treatment services; trend

PROJECT SUMMARY / DESCRIPTION Does maternal infection by the SARS-CoV-2 virus during pregnancy harm the developing fetal brain or increase the sensitivity to later developmental and environmental insults? he novel coronavirus (Covid-19) outbreak has fundamentally altered the child health landscape, ushering in sweeping changes in the social and economic fabric within which children grow. The rapidity of these environment changes, coupled with the relatively novelty of the SARS-CoV-2 virus and the widespread nature of infections, have presented multiple pressing questions. Among the unknowns that directly affect newborn and child health are: 1. How does Covid-19 infection during pregnancy effect the developing fetus or subsequent infant neurodevelopment? And 2. How will the unprecedented scale and scope of concurrent environmental changes impact child health and neurodevelopment? Unfortunately, over the course of the outbreak, the impact on children has been slow to be recognized with studies of Covid-19 infection or effects in infants and young children sparse to nonexistent. Moreover, while the health and economic impacts of the Covid-19 outbreak have been felt by everyone, the most severe effects have be felt by racial and ethnic minorities and lower income families. Thus, the most sensitive families and children already at risk for worsened neurodevelopmental outcomes are disproportionately and more intensely affected. Studies of newborns and infants are, therefore, critical to designing effective guidelines of care for expectant mothers, optimizing early care and support for mothers and their newborns, and prioritizing pre- and postnatal interventions. This supplement proposal aims to contribute important and timely evidence for these outcomes by characterizing neurodevelopmental profiles in infants born to mothers with and without antenatal Covid-19 infection, and examining the concurrent impact of social, economic, and substance use factors. Building on two existing and on-going studies of infant neurodevelopment (R34DA050284 and UH3OD023313), with deeply characterised longitudinal neuroimaging, neurocognitive, socioeconomic, demographic, psychosocial and biospecimen data, we will first investigate differences in brain structure, function, and connectivity development from birth to 1yr of age in infants born to mothers who were infected by the SARS-CoV-2 virus during pregnancy and born between May 1, and Sept. 1, 2020, compared to infants recruited at the same time but to non-infected mothers. We will also examine the impact of infection timing during pregnancy and symptom severity on brain measures. Next, we will compare these brain development trends to data from children who turned 1year old prior to Jan. 1, 2020, allowing us to examine the impact of specific environmental factors, including maternal and infant stress, nutrition, sleep health, and parent- child interaction that have changed due to outbreak-related lock-down and social distancing polices. We will further look at these environmental factors through a racial and socioeconomic lens, examining differences across race and income dimensions.

项目概要/描述 母亲在怀孕期间感染SARS-CoV-2病毒是否会损害发育中的胎儿大脑或增加 对后来的发展和环境的侮辱的敏感性？新型冠状病毒（COVID-19）爆发， 从根本上改变了儿童健康状况，带来了社会和经济的全面变化， 孩子们在其中成长。这些环境的快速变化，加上相对新奇的 SARS-CoV-2病毒和感染的广泛性提出了许多紧迫的问题。 直接影响新生儿和儿童健康的未知因素包括：1。2019冠状病毒感染如何在 怀孕影响发育中的胎儿或随后的婴儿神经发育？和2.将如何 同时发生的环境变化的规模和范围前所未有， 神经发育？不幸的是，在疫情爆发的过程中，对儿童的影响一直缓慢， 在婴儿和幼儿中进行的Covid-19感染或影响研究很少或不存在。 此外，尽管每个人都感受到了COVID-19疫情对健康和经济的影响， 受影响最严重的是少数种族和族裔以及低收入家庭。因此， 敏感的家庭和儿童已经有神经发育结果恶化的风险， 不成比例地受到更严重的影响。因此，对新生儿和婴儿的研究至关重要， 制定有效的孕妇护理准则，优化对母亲的早期护理和支持， 儿童的健康和安全，并优先考虑产前和产后干预措施。本补充提案旨在促进 这些结果的重要和及时的证据，通过描述出生在婴儿的神经发育概况， 对有和没有产前COVID-19感染的母亲，并研究社会， 经济和物质使用因素。基于两项现有和正在进行的婴儿神经发育研究 （R34 DA 050284和UH 3 OD 023313），具有深度表征的纵向神经成像、神经认知， 社会经济学、人口统计学、社会心理学和生物样本数据，我们将首先研究大脑的差异， 出生至1岁婴儿的结构、功能和连接性发育， 在怀孕期间感染SARS-CoV-2病毒，并在5月1日至9月1日期间出生。2020年1月1日，与 同时招募的婴儿，但母亲未受感染。我们还将研究感染的影响 怀孕期间的时间和大脑测量的症状严重程度。接下来，我们将比较这些大脑 发展趋势的数据来自2020年1月1日之前年满1岁的儿童，使我们能够检查 具体的环境因素的影响，包括产妇和婴儿的压力，营养，睡眠健康，和父母， 由于疫情相关的封锁和社交距离政策而改变的儿童互动。我们将 通过种族和社会经济的透镜进一步研究这些环境因素， 跨越种族和收入维度。

项目成果

Remote and at-home data collection: Considerations for the NIH HEALthy Brain and Cognitive Development (HBCD) study.

• DOI: 10.1016/j.dcn.2022.101059
• 发表时间: 2022-04
• 期刊: Developmental cognitive neuroscience
• 影响因子: 4.7
• 作者: Deoni SCL;D'Sa V;Volpe A;Beauchemin J;Croff JM;Elliott AJ;Pini N;Lucchini M;Fifer WP
• 通讯作者: Fifer WP

Development of a mobile low-field MRI scanner.

• DOI: 10.1038/s41598-022-09760-2
• 发表时间: 2022-04-05
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Deoni SCL;Medeiros P;Deoni AT;Burton P;Beauchemin J;D'Sa V;Boskamp E;By S;McNulty C;Mileski W;Welch BE;Huentelman M
• 通讯作者: Huentelman M

Connecting inside out: Development of the social brain in infants and toddlers with a focus on myelination as a marker of brain maturation.

• DOI: 10.1111/cdev.13649
• 发表时间: 2022-03
• 期刊: CHILD DEVELOPMENT
• 影响因子: 4.6
• 作者: Schneider, Nora;Greenstreet, Elizabeth;Deoni, Sean C. L.
• 通讯作者: Deoni, Sean C. L.