Biomathematical Evaluation of Colon Cancer Screening and Prevention

项目摘要 尽管丰富的实验、临床和流行病学数据帮助确定了重要的 结直肠癌的遗传成分和途径，结直肠癌仍然是第二大致病因素 据预测，2008年仅在美国就有近50,000人死于癌症。因为 结直肠癌主要发生在良性前驱病变(主要是腺瘤性息肉)，这些病变可能会暂住。 在癌变之前的许多年里，结直肠癌基本上可以通过筛查和及时治疗来预防 干预。这次更新的目标是通过对自然环境的生物数学描述，进一步探索 结直肠癌的历史，如何最有效地应用筛查和干预措施来降低死亡率 与CRC关联

Project Summary In spite of the wealth of experimental, clinical and epidemiological data that have helped identify important genetic components and pathways in colorectal cancer (CRC), CRC continues to be the second leading cause of cancer associated death, with close to 50,000 deaths predicted for the year 2008 in the US alone. Because CRC arises predominantly in benign precursors (mainly the adenomatous polyps), which are likely to sojourn for many years before they turn malignant, CRC can be prevented largely through screening and prompt intervention. The goal of this renewal is to further explore, via a biomathematical description of the natural history of CRC, how screening and interventions can be applied most effectively to reduce the mortality associated with CRC